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김송이(Kim, Song-Yee),이지윤(Lee, Ji-Yun),김현정(Kim, Hyeon-Jeong),안나영(Ahn, Na-Young),로산와글레(Wagle, Roshan),장현태(Jang Hyun Tae) 한국산학기술학회 2008 한국산학기술학회 학술대회 Vol.- No.-
본 연구에서는 석탄회재를 이용하여 메조 포러스 실리카를 제조하였다. 제조된 메조포러스 실리카는 X-선 회절패턴, TEM, FT-IR을 통하여, HMS특성과 동일하게 나타났으며 결과적으로 메조 포러스 실리카 물성에 가장 영향을 나타내는 것은 반응온도, 시간이며 석탄 회재의 규소용출은 소성온도가 낮을수록 증가하며 규소원에 따라 각기 다른 특성을 나타냄을 합성된 메조포러스 실리카의 물리화학적 특성으로부터 알 수 있었다.
Pain Asymbolia: No Pain No Love
김송이,채윤병 대한스트레스학회 2011 스트레스硏究 Vol.19 No.4
Pain has been defined as a conscious experience, an interpretation of the nociceptive input influenced by multiple components, including sensory-discriminative, affective-dimensional, and cognitive-evaluative. Pain asymbolia, one of neuropsychological disorders, is a condition in which pain is perceived, but does not cause suffering. We would like to explain the pain asymbolia from the perspective of neuropsychology. The current review summarized the existing brain lesion evidence for the anatomical basis of pain asymbolia. The somatosensory cortices are more involved in the perception of sensory features, whereas limbic and paralimbic regions, such as anterior cingulate cortex and insula, are associated with the emotional and motivational aspects of pain. The understanding of the neural substrates of pain processing and the neurological characteristics of pain asymbolia would help us to identify the putative anatomical basis of the neuropsychological disorder.
김송인,이원기,강상수,Sue-Young Lee,Myeong-Ja Jeong,이희제,김성수,Gall V. W. Johnson,전완주 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.2
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer’s disease. GSK3β has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate the aggregate formation of tau. The present study examined the role of GSK3β-mediated phosphorylation of tau species on their autophagic degradation. We transfected wild type tau (T4),caspase-3-cleaved tau at Asp421 (T4C3), or pseudophosphorylated tau at Ser396/Ser404 (T4-2EC) in the presence of active or enzyme-inactive GSK3β. Trehalose and 3-methyladenine (3-MA) were used to enhance or inhibit autophagic activity, respectively. All tau species showed increased accumulation with 3-MA treatment whereas reduced with trehalose, indicating that tau undergoes autophagic degradation. However, T4C3 and T4-2EC showed abundant formation of oligomers than T4. Active GSK3β in the presence of 3-MA resulted in significantly increased formation of insoluble tau aggregates. These results indicate that GSK3β-mediated phosphorylation and compromised autophagic activity significantly contribute to tau aggregation.