Value of the Post-Operative CT in Predicting Delayed Flap Failures Following Head and Neck Cancer Surgery

김빛나,윤대영,서영란,박민우,권기환,노영수,정철훈 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.3

Objective: To identify post-operative computed tomography (CT) findings associated with delayed flap failures following head and neck cancer surgery. Materials and Methods: We retrospectively reviewed 60 patients who underwent flap reconstruction after head and neck cancer surgery and post-operative (3–14 days) contrast-enhanced CT scans for suspected complications. Patients were divided into two groups: delayed flap failure patients (patients required flap revision) (n = 18) and flap success patients (n = 42). Clinical data (age, sex, T-stage, type of flap, and time interval between reconstruction surgery and CT) and post-operative CT findings of flap status (maximum dimension of the flap, intra- or peri-flap fluid collection and intra- or peri-flap air collection, fat infiltration within the flap, fistula to adjacent aerodigestive tract or skin, and enhanced vascular pedicle) were assessed and compared between the two groups. Results: CT findings showed that the following flap anomalies were observed more frequently in the delayed flap failure group than in the flap success group: intra- or peri-flap fluid collection > 4 cm (61.1% vs. 23.8%, p < 0.05), intra- or peri-flap air collection > 2 cm (61.1% vs. 2.4%, p < 0.001), and fistula to adjacent aerodigestive tract or skin (44.4% vs. 0%, p < 0.001). The maximum dimension of the flap, fat infiltration within the flap, and enhanced vascular pedicle were not associated with delayed flap failures. Conclusion: A large amount of fluid or air collection and fistula are the CT findings that were associated with delayed flap failures in patients with suspected post-operative complications after head and neck cancer surgery.

경조성 성격을 가진 양극성 장애 위험군에서 행동활성화체계의 과민감성과 기분증상의 관계

김빛나,권석만 한국임상심리학회 2016 Korean Journal of Clinical Psychology Vol.35 No.3

Among the recently proposed psychological theories of bipolar disorder, the behavioral activation system (BAS) model is considered as one of the most promising working models. Although the BAS model of bipolar disorder received extensive empirical support in Western countries, the applicability of this model in different cultures remains untested. As a preliminary step to test its applicability in Korea, the main objective of this study is twofold. First, we attempted to investigate whether BAS sensitivity is elevated in Korean high-risk group with hypomanic personality. Second, we tested whether BAS sensitivity is a significant predictor of mood symptoms in conjunction with behavioral inhibition system (BIS) sensitivity. The results showed that the level of BAS sensitivity was heightened in the undergraduate high-risk group defined as those in the upper decile of the Hypomanic Personality Scale. In regression analyses, high BAS and low BIS sensitivities contributed to more (hypo)manic symptoms, thereby confirming the assumption that (hypo) mania reflects BAS hyperactivation and failure of BIS inhibition. Conversely, low BAS and high BIS sensitivities predicted more depressive symptoms, suggesting that BAS deactivation corresponds to depression.

In vitro application of redesigned vacuole extracted in yeast

김빛나,Choi Wooil,조병관,민지호 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1

Background The vacuole in the yeast Saccharomyces cerevisiae has vacuoles that contain the similarities with lysosomes, which are acidic compartments containing hydrolytic enzymes in the cell. In the past, research focus was on simple antimicrobial function using hydrolase of vacuoles. Recent studies of vacuoles have uncovered additional roles of vacuoles, and their adaptability to genetic, and biochemical analyses has led to the creation of novel vacuole systems through genetic manipulation and expression control mechanisms. Objectives This review briefly introduces the recently reported applications of vacuoles with potential functions that can overcome the toxic issues in biotechnology fields. Results Several studies found and decorated biomarkers on vacuolar membrane that react to toxic substances and pathogenic bacteria, and succeeded in detecting both with high sensitivity by developed vacuole. In addition, the recombinant yeast including vacuole to overproduce certain enzymes involved in melanin decolorization has constructed. This engineered yeast demonstrated an effect on melanin reduction and antioxidant activity. Recently, it became possible to control the size of the vacuole through manipulation of the YPT7 gene involved in fusion. Research in the field of nanomedicine using nano-sized vacuole is ongoing. Several researchers encapsulated toxic drug to reduce the side effects, and showed its potential and target specificity as drug carriers for cancer treatment. Conclusions Yeast vacuole is being added with novel functions through artificial redesign and genetic engineering. Accordingly, it has drawn a great deal of attention in variety of fields. Therefore, yeast vacuole is expected to be applicable to many fields, and it will provide better opportunities as a new material, especially in fields that value biocompatibility. Purpose of the review Recently, the researchers have been revealed novel functions of vacuole in the yeast Saccharomyces cerevisiae, and their new functions are being emphasized through genetic engineering system and expression control mechanisms. Also, research is being conducted to apply it to various fields. Therefore, this review briefly discusses the recently reported application of vacuoles with potential functions in biotechnology fields. Recent findings In addition to the antibacterial function of the vacuole, which is an acidic compartment consisting of hydrolytic enzymes, various studies are being conducted utilizing new functions of the vacuole. Several studies have reconstructed vacuoles to detect specific analytes through regulation of protein expression. The reconstituted vacuole succeeded in detecting certain toxic substances and pathogens. In addition, research on the cosmetic field using the hydrolysis and antioxidant functions of enzymes in the vacuole is being conducted. Accordingly, studies have been published to prove the effect on melanin reduction and antioxidant activity of vacuoles to overproduce certain enzymes. Recently, it has become possible to control the size of vacuoles through genetic manipulation, and research for application in nanomedicine is underway. In particular, utilizing their potential as drug carriers, research results on toxic drug encapsulation and cancer treatment are being reported.

박막 BIPV창의 온도변화와 발전성능 상관관계에 관한 실측연구

김빛나,윤종호,신우철,Kim, Bit-Na,Yoon, Jong-Ho,Shin, U-Cheul 한국태양에너지학회 2012 한국태양에너지학회 논문집 Vol.32 No.suppl3

This research on building Integrated Photovoltaic System replacing windows and doors with amorphous silicon thin film PV windows and doors installing same exact mount on Mock-up. The windows and doors should be installed in different angle and bearing so that we can analyse the amount of electricity from them. The objective of the research is to evaluate and investigate the relationship between factors(intensity of solar radiation, PV window surface temperature, incidence angle, and sky conditions) that affects performance of PV window and performance. The range and method of this research is to establish monitoring system and analysis the data from the monitoring system to evaluate the performance of PV windows that have thin film of solar battery. We should evaluate the insolation according to the position of PV window, output, and surface temperature according to months and seasons so that we can figure out the relationship between these. And we should investigate the relationship between performance and efficiency according to incidence angle and sky condition so that we can figure out the correlation between factors and performance.

Mating behavior of the Mongolian racerunner (Eremias argus; Lacertidae, Reptilia)

김빛나,박대식,김자경 한국통합생물학회 2012 Animal cells and systems Vol.16 No.4

Information about the mating behaviors of an endangered species is critical for the understanding of the natural history of the species as well as in situ and ex situ breeding programs designed to rehabilitate field populations. We describe the mating behaviors of the Mongolian racerunner (Eremias argus), an endangered species in South Korea. The mating of this species consists of precopulatory, copulatory, and postcopulatory stages and is composed of 12different mating behaviors. During the postcopulatory stage, other males or females not involved in mating show more interference behaviors than during the precopulatory and copulatory stages. The male E. argus has an extraordinarily long postcopulatory bite, which may function as a type of mate-guarding behavior. This study is the first report on the mating behavior of a South Korean reptile.

식생활 라이프스타일 유형이 다이어트 도시락 선택속성의 중요도에 미치는 영향

김빛나,심기현 한국식품영양학회 2017 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2017 No.06

이중 연속 탄소 구조 소재를 활용한 에너지 저장장치 전극의 특성

김빛나,김종필,윤장희 한국표면공학회 2022 한국표면공학회 학술발표회 초록집 Vol.2022 No.11

Initial Psychometric Properties of the Korean Altman Self-Rating Mania Scale: Preliminary Validation Study in a Non-Clinical Sample

김빛나,권석만 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.5

Objective: We aimed to examine the reliability and validity of the Korean Altman Self-Rating Mania Scale (K-ASRM) in a large sample of Korean non-clinical undergraduates. Methods: Participants (n=1,091) filled out the K-ASRM with other self-report questionnaires assessing bipolarity, mood symptoms and affect. Reliability test, exploratory factor analysis and correlation analyses were conducted to examine its psychometric properties. Results: The reliability of the K-ASRM was adequate (Cronbach’s α=0.73, item-to-total correlation 0.53–0.78) and the exploratory factor analysis yielded one factor of mania. The K-ASRM demonstrated significant associations with measures of hypomanic personality (r=0.33), lifetime history of hypomanic symptoms (r=0.23). Also, the K-ASRM was significantly correlated with positive affect (r=0.53), negative affect (r=-0.17) and depressive symptoms (r=-0.35). Conclusion: These results suggest preliminary possibility that the K-ASRM can be utilized as self-rating tool for mania in Korea as well as future directions for further validation.

실험실과 야외현지에서 표범장지뱀 (Eremias argus)의 산란 및 알의 부화 특성

김빛나,김일훈,김자경,박대식 한국양서·파충류학회 2010 한국양서·파충류학회지 Vol.2 No.1

행동활성화체계 민감성이 양극성 장애 위험군의 기능적 장해에 미치는 영향: 충동성의 조절효과

김빛나,권석만 한국임상심리학회 2017 Korean Journal of Clinical Psychology Vol.36 No.2

Bipolar disorder (BD) is characterized by diverse functional impairments as well as recurrent mood fluctuations. Based on the behavioral activation system (BAS) model of BD, we explored the possibility that heightened BAS sensitivity, vulnerability for BD within the model, can also be related to functional indices associated with BD. Among a large undergraduate sample (N=531), we screened a BD high-risk group (n=64) via the Hypomanic Personality Scale and examined the relationship between BAS sensitivity, problematic drinking, and academic maladaptation with impulsivity as a moderator. The results showed that high BAS sensitivity, when combined with high impulsivity, could impair academic achievement in the high-risk group. On the contrary, the main effect of impulsivity was only significant in predicting problematic drinking. The present study suggests that BAS sensitivity is related to not only symptomatic but also functional aspects of BD. Future research should continue to investigate if BAS sensitivity may account for both negative and positive features of adaptation associated with BD.