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김봉영,이은영,배명진 사단법인 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.2
Man has a different voice. This characteristic of the voice is like a fingerprint that distinguishes the person. Because the characteristics of individuals such as physical structure and lifestyle are different, voices are a characteristic that can distinguish individuals. These different voice characteristics are interested as a means of biometric authentication. On the other hand, it would be hard to distinguish the voices which are very similar among the family members. At this time, the genetic factors work the most role. In this paper, using newly developed sound A color, we tried to compare voice with more intuitive and simpler. The experiment was for 6 male and female voices by using voice frequency band of 0~4 KHz Sound A color and we have done a comparative analysis of the result. As a result of the experiment, it was intuitively understood that even the visual expression of the sound A color is different by the individual voice characteristics, and it can be seen that the sound A color also can be used as an index for discriminating the individual voice characteristics. 사람은 저마다 서로 다른 목소리를 가지고 있다. 이러한 목소리 특성은 마치 지문처럼 그 사람을 구분할 수 있는 특징이 된다. 신체적 구조와 생활습관과 같은 개인 간의 특성이 다르기 때문에 목소리가 개개인을 구분할 수 있는 특성이 되는 것이다. 이러한 서로다른 목소리 특성은 생체인증 수단으로써 관심을 받고 있다. 반면 가족 간에는 목소리가 매우 유사하여 구분하기 어려운 경우가 발생하게 되는데, 이때 유전적인 요인이 가장 크게 작용한다. 본 논문에서는 최근 새로이 연구되고 있는 사운드 A칼라를 이용하여 좀더 직관적이고 좀 더 간단한 목소리 비교를 시도하였다. 실험은 남녀 6인의 목소리에 대하여 0~4 KHz의 음성주파수 대역을 사운드 A칼라로 표현하여 그 결과를 비교분석 하였다. 실험을 진행한 결과, 사운드 A칼라의 시각적인 표현만으로도 개인별 목소리 특성에 차이가 있음을 직관적으로 알 수 있었으며, 사운드 A칼라가 개인별 목소리 특성을 구분할 수 있는 지표로도 활용 가능함을 알 수 있다.
에이즈 환자에서 발생한 비타민 B12 결핍에 의한 거대 적혈모구 빈혈
김봉영,김지은,황순우,이유화,박정환,문신제,최지영,송준석,정종헌,배현주 대한감염학회 2011 Infection and Chemotherapy Vol.43 No.3
Anemia is the most common hematologic finding in patients with advanced infections caused by human immunodeficiency virus (HIV) or advanced acquired immunodeficiency syndrome (AIDS). Among many etiologies of HIVassociated anemia, vitamin B12 deficiency plays an important role, mostly due to malabsorption or HIV enteropathy. We experienced a case of megaloblastic anemia caused by vitamin B12 deficiency in a male patient with an AIDS who had no structural gastrointestinal problem. He showed severe anemia, leukopenia, thrombocytopenia and suspicious neurologic manifestations such as aggravation of dementia and gait disturbance. With vitamin B12 and folate treatment, the patient’s general condition and hematologic features were improved successfully.
Descriptive Epidemiology of Acute Pyelonephritis in Korea, 2010–2014: Population-based Study
김봉영,명랑미,김지은,이명재,배현주 대한의학회 2018 Journal of Korean medical science Vol.33 No.49
Background: Acute pyelonephritis (APN) is one of the most common community-acquired bacterial infections. Recent increases of antimicrobial resistance in urinary pathogens might have changed the other epidemiologic characteristics of APN. The objective of this study was to describe the current epidemiology of APN in Korea, using the entire population. Methods: From the claims database of the Health Insurance Review and Assessment Service in Korea, the patients with International Classification of Diseases, 10th Revision codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, neither acute nor chronic) as the primary discharge diagnosis during 2010–2014 were analyzed, with two or more claims during a 14-day period considered as a single episode. Results: The annual incidence rate of APN per 10,000 persons was 39.1 and was on the increase year to year (35.6 in 2010; 36.7 in 2011; 38.9 in 2012; 40.1 in 2013; 43.8 in 2014, P = 0.004). The increasing trend was observed in both inpatients (P = 0.014) and outpatients (P = 0.004); in both men (P = 0.042) and women (P = 0.003); and those aged under 55 years (P = 0.014) and 55 years or higher (P = 0.003). Eleven times more women were diagnosed and treated with APN than men (men vs. women, 6.5 vs. 71.3), and one of every 4.1 patients was hospitalized (inpatients vs. outpatients, 9.6 vs. 29.4). The recurrence rate was 15.8%, and the median duration from a sporadic episode (i.e., no episode in the preceding 12 months) to the first recurrence was 44 days. The recurrence probability increased with the number of previous recurrences. The average medical cost per inpatient episode was USD 1,144, which was 12.9 times higher than that per outpatient episode (USD 89). Conclusion: The epidemiology of APN in Korea has been changing with an increasing incidence rate.
Density Gradient를 이용한 식품소재를 커들란의 분리공정개발
김봉영,이중헌 한국생물공학회 2001 KSBB Journal Vol.16 No.5
커들란은 용액의 pH 7.0에서 salt 상태로 존재하기 때문에 커들란만이 액상에 녹아 있는 경우에는 분리공정은 원심분리를 함으로써 분리가 가능하다. 그러나, 세포외 다당류로 생산된 커들란읜 세포, 염 의 무기물이 섞여 있기 때문에 이러한 물질을 제거하는 것이 커들란 분리의 중요한 변수가 되었다. 커들란의 생산을 위한 분리에 관한 보고는 원심분리 방법을 이용한 것으로 알려져 있음 세포 및 불순물 등을 제거하여 순수한 커들란을 분리하기 위해 pH swing separation (pH가 높은 경우 커들란이 용액에 녹는 성질을 이용)을 이용하였으나 원심분리를 수 차례 반복해야 되기 때문에 소요되는 동력이 많이 필요하여 에너지 절감형 및 오염절감형의 새로운 공정의 개발이 필요하게 되었다. 온 연구에서는 pH swing separation 에서 동력비가 많은 드는 단점을 감소시키기위하여 커들란의 물리 화학적인 특성을 고려한 분리공정을 개발하였다. 향후 공정 개선을 위한 지속적인 연구가 필요하며 완성시 경제적이 공정을 개발하는 것이 가능할 것이다. Curdlan is one biopolymer composed of ${\beta}$1,3-glucan and dissolved in a alkali solution but formed salt under neutral or acid condition. It was produced by Agrobactrium species and the separation process is necessary to make pure curdlan from the culture broth. The pH swing separation method was as feasible separation process using solubility changes with the pH difference. however, this method requires a lot of acid and alkali solution also produces a lot of waste. Therefore, an efficient process which could save energy and minimize toxic waste was developed. A density gradient separation process was developed in this research. High density sucrose solution was used as a separation agent. Curdlan was separated from the culture broth when the density of the sucrose solution was 1.15 g/L. Since the curdlan was produced on the surface of cell wall. the pre-treatment of culture broth was necessary. Curdlan recovery yield was increased up to 83% with the homogenization of the culture broth and further increased up to 87% with the treatment of alkai-acid solution.