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Treatment Outcomes of Venlafaxine and Duloxetine in Refractory Burning Mouth Syndrome Patients
김문종,고홍섭 대한안면통증∙구강내과학회 2019 Journal of Oral Medicine and Pain Vol.44 No.3
Purpose: Venlafaxine and duloxetine have been shown to be effective in the treatment ofneuropathic pain disorders. However, knowledge about the efficacy of venlafaxine and duloxetineon burning mouth syndrome (BMS) is still insufficient. The purpose of this studywas to investigate the efficacy of venlafaxine and duloxetine on refractory BMS patients. Methods: Twelve refractory BMS patients who were prescribed venlafaxine or duloxetinewere included in this study. These patients did not respond to previous administration ofclonazepam, alpha-lipoic acid, gabapentin, and nortriptyline. All participants were the primarytype of BMS patients who had no local and systemic factors related to the oral burningsensation. The intensities of oral symptoms following venlafaxine or duloxetine administrationwere compared with those before administration and at baseline. Results: Venlafaxine and duloxetine were prescribed to four and nine patients, respectively. One patient was prescribed both medications in turn. Among them, only two patientsshowed improvement of oral symptoms without side effects. In the other ten patients,symptoms failed to improve. Six of them reported that the drug was ineffective, and fourof them stopped taking the medications on their own due to intolerable side effects, such asinsomnia, constipation, drowsiness, dizziness, and xerostomia. Conclusions: Venlafaxine and duloxetine may only relieve oral symptoms in a minority ofrefractory BMS patients. Further large-scale studies are needed to determine the potentialclinical factors that could predict the efficacy of venlafaxine and duloxetine.
후기 발현 남성 성선기능저하증에 대한 2006 대한남성갱년기학회 호르몬치료 권고안
김문종,이유미,서주태,양대열,문두건,박남철,김제종 대한남성과학회 2008 The World Journal of Men's Health Vol.26 No.1
Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout the world. The evidence from results showing that testosterone decrease progressively with age and that a significant percentage of men over the age 60 years have serum testosterone levels that are below the lower limits of young adults(age 20∼30) men suggest that older hypogonadal men will benefit from testosterone replacement therapy. Long term data on the effects of testosterone replacement therapy in the older population, however, are limited and specific risk data on the prostate and cardiovascular systems are needed. Key questions of functional benefits that may retard frailty of the elderly are not yet available. The recommendations described below were based on document suggested by the International Society of Andrology(ISA), the International Society for the Study of the Aging Male(ISSAM) and the European Association of Urology(EAU) in 2005. The academic committee of the Korean Society for the Aging Male Research(KOSAR) suggested these recommendations to provide the appropriate information about investigation, treatment and monitoring for late-onset hypogonadism in aging Korean men following an annual meeting in October 2006.
Application of Laboratory Medicine in the Field of Oral Medicine
김문종 대한안면통증∙구강내과학회 2022 Journal of Oral Medicine and Pain Vol.47 No.4
Various diseases of the orofacial region that are treated in the field of oral medicine not only are associated with local factors but may also be affected by systemic factors. Knowledge about laboratory medicine is needed to identify the systemic factors that can influence these diseases. Therefore, oral medicine specialists should be able to use diagnostic tests of laboratory medicine and interpret the results in diagnosing and treating diseases in the field of oral medicine. The aim of this article is to examine the diagnostic tests used in laboratory medicine that might be applied to assess the systemic aspect of diseases in the field of oral medicine and to interpret the significance of the findings.
The Circadian Rhythm Variation of Pain in the Orofacial Region
김문종,정진우,고홍섭,박지운 대한안면통증∙구강내과학회 2015 Journal of Oral Medicine and Pain Vol.40 No.3
All living organisms have a biological clock that orchestrates every biological process andfunction, and this internal clock operates following a circadian rhythm. This biological clockis known to influence various clinical indicators such as blood pressure and body temperature. Also, the fluctuation of signs and symptoms of diseases including pain disorders are affectedby circadian rhythm. It has been reported that the pain intensity of various somatic and neuropathicpain disorders show unique pain patterns that depend on the passage of time. The generationof pain patterns could be explained by extrinsic (e.g., physical activity, tactile stimulation,ambient temperature) and also intrinsic factors (neural and neuroendocrine modulation)that are related to the circadian rhythm. It is important to recognize and identify the individualpain pattern in pain therapy to approve treatment outcome. Moreover, chronotherapeuticswhich considers pain patterns and pharmacokinetics in context of the circadian rhythm couldproduce greater analgesia in response to medication. However, only a limited number of studieshandle the issue of pain patterns according to circadian rhythm and chronotherapeutics inthe orofacial region. The present review intends to reflect on the most recent and relevant dataconcerning the bidirectional relation between pain disorders of the orofacial region and circadianpatterns.