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위눈꺼풀에 발생한 원발성 기타 상세불명의 말초 T세포 림프종 1예
노시진,기정혜,김혜영,Si Jin Noh,Jeong Hae Kie,Hye Young Kim 대한안과학회 2012 대한안과학회지 Vol.53 No.11
Purpose: To report a case of primary peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), of the eyelid. Methods: A 48-year-old healthy male patient presented with a mass on the upper lid of 2 months in duration. The lesion was reddish, well - demarcated, oval shaped, and measured approximately 8 × 4 mm. The mass did not respond to incisional drainage and intra-lesional triamcinolone. An excisional biopsy for diagnosis was performed. Results: On microscopic examination, a localized dense lymphocytic infiltration was observed in the subepithelial area, and cytologic atypia was observed under high power. On immunohistochemical examination, tumor cells were positive for CD3 but negative for CD20, CD30, CD56, ĸ-light chain immunoglobulin, λ-light chain immunoglobulin, and increased Ki-67 activity was noted. A histopathological diagnosis of PTCL-NOS was made. Conclusions: PTCL-NOS, which rarely occurs on the eyelids, commonly accompanies generalized lymphadenopathy and “B symptoms” such as fever and weight loss. Herein, the authors report a case of PTCL-NOS of the eyelid presenting as a rapidly growing solid mass in an otherwise healthy patient.
안현민(Hyun Min Ahn),기정혜(Jeong Hae Kie),김혜영(Hye Young Kim) 대한안과학회 2017 대한안과학회지 Vol.58 No.7
목적: 안과 영역에서 결핵은 결막결절이나 포도막염 형태로 흔히 나타나며 안와의 감염은 매우 드물다. 저자들은 양측 안와에 발생한 종괴에서 결핵을 진단하여 이를 보고하고자 한다. 증례요약: 64세 남성이 복시를 주소로 내원하였다. 과거력상 당뇨와 고혈압, 만성폐쇄성폐질환의 병력이 있었다. 양안의 교정시력은 1.0, 안압은 16 mmHg였으며, 양안에 안구돌출이 있었고, 양안 모두 하측 안와에서 종괴가 촉진되었다. 안와 컴퓨터단층촬영상, 근원추 바깥쪽에서 안구를 전체적으로 불규칙하게 둘러싸는 경계가 불명확한 종괴가 양안 모두에서 관찰되었다. 국소마취하에 양안에서 종양의 절개생검을 시행하였으며 병리조직검사상 건락괴사가 동반된 만성 육아종성 염증이 관찰되어 양안 안와 결핵으로 진단하였다. 호흡기내과에 전원하여 Isonizid, Rifampin, Ethambutol 3제 요법으로 치료를 12개월간 유지하여 종괴는 완전히 소실되었으며 치료 종료 12개월 후까지 재발이나 합병증은 없었다. 결론: 양안 안와에 발생한 종괴에서 결핵을 진단하고 치료하였으며 안와 결핵은 국내에 보고된 바 없기에 이를 보고하는 바이다. <대한안과학회지 2017;58(7):862-865> Purpose: Periocular tuberculosis is common in the form of conjunctival tuberculosis or uveitis; however, orbital tuberculosis is very rare. We report a case of tuberculosis diagnosed based on bilateral orbital masses. Case summary: A 64-year-old male with a history of diabetes, hypertension, and chronic obstructive pulmonary disease presented with diplopia. His best-corrected visual acuity was 1.0, and intraocular pressure was 16 mmHg in both eyes. Bilateral proptosis was noted, and inferior orbital masses were palpated in both eyes. On orbital computed tomography, irregular masses were surrounding both globes in the extraconal space. Incisional biopsy of the bilateral orbital masses was performed under local anesthesia. Pathologic examination revealed chronic granulomatous inflammation accompanied by caseous necrosis. The patient was diagnosed with bilateral orbital tuberculosis and underwent triple therapy with isoniazid, rifampin, and ethambutol for 12 months. The orbital masses completely resolved, and there was no recurrence or complication through 12 months after treatment. Conclusions: To our knowledge, bilateral orbital tuberculosis has not been reported yet. Herein, we report a case of orbital tuberculosis presenting as bilateral orbital masses. J Korean Ophthalmol Soc 2017;58(7):862-865
AA 아밀로이드증에서 Infliximab (Remicade(R)) 치료
김다함 ( Da Ham Kim ),박경혜 ( Kyeong Hye Park ),이수환 ( Su Hwan Lee ),현신영 ( Shin Young Hyun ),기정혜 ( Jeong Hae Kie ),강이화 ( Ea Wha Kang ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.5
AA amyloidosis is one of the most significant complications of rheumatoid arthritis characterized by the deposition of amyloid A (AA) in multiple organs and tissues in the body. This disorder displays variable clinical symptoms depending upon the involved organ and a diagnosis is rendered through a biopsy of the affected organ, followed by staining using Congo-red which reveals an apple-green birefringence. Fundamental disease control is critical in the treatment of AA amyloidosis. Anti-tumor necrosis factor alpha (anti TNF- ) agents are promising in inducing clinical remission by suppressing systemic inflam α - mation in AA amyloidosis. We report a case of AA amyloidosis in a 71 year old woman with rheumatoid arthritis that responded well to infliximab therapy.
근치적 신절제술 후 7년만에 기관지내 전이로 발견된 신세포암
김도현 ( Do Hyun Kim ),김선혜 ( Sun Hye Kim ),김동환 ( Dong Hwan Kim ),나형중 ( Hyoung Jung Na ),이주현 ( Ju Hyun Lee ),이선민 ( Sun Min Lee ),김정주 ( Chong Ju Kim ),기정혜 ( Jeong Hae Kie ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.5
A distant metastasis from a renal cell carcinoma is quite common after a radical nephrectomy. For this reason, a5 year scheduled follow up is recommended. However, a distant metastasis 5 years after the resection is quite rare. We encountered an endobronchial metastasis from a renal cell carcinoma that was discovered 7 years after the radical nephrectomy, and did not present during the 5 year scheduled follow up regimen. We report this case with a review of the literatures. (Tuberc Respir Dis 2006; 61: 496-500)
Sertoli - Leydig Cell Tumor 1 예
한상원 ( Sang Won Han ),김태윤 ( Tae Yoon Kim ),권혜경 ( Hye Kyung Kwon ),강경숙 ( Gyoung Sook Kang ),연혜정 ( Hye Jeong Yeon ),기정혜 ( Jung Hye Kie ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
The Sertoli-Leydig cell tumor is a rare sex cord stromal tumor of the ovary, accounting for less than 0.5% of all primary ovarian neoplasm. This tumor is the most common type of all virilizing ovarian tumors. However, only one-third of patients develop virilization. Recently, we experienced a case of intermediately differentiated Sertoli-Leydig cell tumor with amenorrhea and so we present it with brief review of literature.
자궁경부에 발생한 T/Natural killer cell 림프종
손가현 ( Ga Hyun Son ),전순례 ( Soon Rye Jeon ),조예성 ( Ye Sung Cho ),정현주 ( Hyun Joo Jung ),조혜진 ( Hye Jin Cho ),조희영 ( Hee Young Cho ),기정혜 ( Jeong Hae Kie ),최은경 ( Eun Kyoung Choi ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
Non-Hodgkin`s lymphoma presented as a malignancy of the uterine cervix is exceedingly rare disease and accounts for approximately only 0.12-0.6% of extranodal lymphomas. Most reported cases were B-cell lymphomas and there is no consensus on the management and prognosis of the disease because of its extreme rarity. Primary T/natural killer (NK)-cell lymphoma arising from the uterine cervix is scarcely encountered that, in the review of literature, only 1 case has been reported by Mhawech et al. We encountered a woman with T/NK-cell lymphoma involving the uterine cervix that initially presented with severe vaginal bleeding. Therefore, we report the case with a brief review of literature.
최유리 ( Yu Ri Choi ),이찬희 ( Chan Hee Lee ),강이화 ( Ea Wha Kang ),차민섭 ( Min Seob Cha ),김하나 ( Ha Na Kim ),기정혜 ( Jeong Hye Kie ),박수미 ( Su Mi Park ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.2
Systemic lupus erythematosus (SLE) is a multisystem inflammatory disorder mediated by autoantibodies and immune complexes that exhibit a range of symptoms. Although thirty-five to forty percent of patients with SLE show signs or symptoms of gastrointestinal involvement, acute pancreatitis is an uncommon complication of SLE, and SLE presenting with acute pancreatitis is extremely rare. We report a case of a 28-year-old female SLE patient who initially presented with acute abdominal pain and elevated pancreatic enzyme levels. The patient was diagnosed clinically with acute pancreatitis and then with SLE after further investigations. Her condition improved after high dose steroid therapy.
미세변화 신증후군과 국소성 분절성 사구체경화증에서 사구체 크기와 수의 비교
황현희 ( Hyun Hee Hwang ),윤봉식 ( Bong Sik Yoon ),김기혁 ( Kee Hyuck Kim ),신석균 ( Sug Kyun Shin ),강이화 ( Ea Wha Kang ),유태현 ( Tae Hyun Yoo ),기정혜 ( Jeong Hye Kie ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.5
Purpose : It has been proposed that a decreased nephron number may be associated with the increased risk of glomerulosclerosis. In order to test the hypothesis that a reduced number and an increased volume of glomeruli may contribute to the pathogenesis of focal segmental glomerulosclerosis (FSGS), we compared the number and volume of glomeruli between 9 patients with FSGS and 8 with minimal change nephrotic syndrome (MCNS). Methods : Mean glomerular volume was measured using the method of Weibel and Gomez. An estimate of glomerular number (index) was obtained by multiplying the cortical volume of a kidney by the fraction of renal cortex made up of glomeruli and dividing this by the mean glomerular volume for that kidney×106. We determined kidney volume from ultrasonographic measurement. Results : Patients with FSGS had significantly greater glomerular volume than patients with MCNS [2.02±0.36 (×106 μm3) vs. 1.57±0.27 (×106 μm3)] (p<0.025). However, there was no significant difference in the index of glomerular number (estimated glomerular number) between FSGS & MCNS patients (2.8±1.4 vs. 3.0±0.8). Conclusion : The glomerular volume was greater in FSGS patients than MCNS patients. But there was no significant difference in the index of glomerular number between patients with FSGS and MCNS.