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β-아드레날린성 수용체 아형에 대한 효현제 및 길항제가 토끼 정낭의 수축 및 이완 반응에 미치는 영향
명순철,금은미,곽경원,이무열,김세철 대한비뇨의학회 2004 Investigative and Clinical Urology Vol.45 No.7
Purpose: This study was aimed at investigating the role of β-adrenoceptor subtypes in mediating the relaxation and contraction of seminal vesicles in rabbits. Materials and Methods: Relaxation or contractile responses of epithelium- removed muscle strips of a rabbit seminal vesicle, which were precontracted with 10-5M norepinephrine, to selective β subtypes-adrenoceptor agonists were observed in an organ bath. The contractile responses induced by isoproterenol were also observed after application of selective antagonists. Results: Isoproterenol showed a concentration-dependent contractile response, but the contractility was weaker than those with phenylephrine and norepinephrine. The β selective-agonists(xamoterol for β1, clenbuterol for β2 and BRL37344 for β3) alone evoked neither contraction nor relaxation. However, the β1- and β3-agonists inhibited the contraction of the precontracted strips with 10-5M norepinephrine, while the β2-agonist enhanced the contraction. The pretreatment with a β2-antagonist(ICI118551) reduced the tension of the strips developed by 10-4M isoproterenol, but the β1-(atenolol) and β3-(SR59230A) antagonists showed no changes in the response. Conclusions: β1- and β3-adrenoceptors seem to mediate the relaxation of the seminal vesicle, while the β2-adrenoceptor may have a supplementary role in contraction. (Korean J Urol 2004;45:726-731)
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인슐린에 의한 가토 정상 음경해면체 평활근의 내피세포 의존성 이완 기전
명순철,한지엽,이용성,금은미,이무열,김세철 대한비뇨의학회 2004 Investigative and Clinical Urology Vol.45 No.8
Purpose: Insulin is known to induce relaxation in various vasculatures by increasing the release of nitric oxide or the expression of nitric oxide synthase. However, its action mechanisms on the corpus cavernosum remain to be uncovered. This study aimed to investigate the relaxative responses and the mechanism of normal cavernous smooth muscles to insulin. Methods and Materials: Rabbit corpus cavernous tissues were prepared in 2x2x8 mm sized strip for isotonic tension recording. The dose-dependent relaxation responses of norepinephrine(10-4M)-precontracted strips to insulin (10-6M) were measured. The relaxation responses of NE(10-4 M)-precontracted strips to insulin(10-6M) were measured under low to high glucose concentrations(0, 0.1, 1 and 11mM) in physiological solution. The relaxation responses of the NE-precontracted strips to insulin(10-6M) were also observed after endothelial denudation, 30-minute preincubation with L-NAME(5mM) or 30-minute preincubation with indomethacin(10-4 M). Results: The cavernosal strips were relaxed by insulin in a dose-dependent manner. The insulin-induced relaxation was dose-dependently increased by glucose. The endothelial denudation or indomethacin pretreatment almost abolished the insulin-induced relaxation, but L-NAME rarely affected the relaxation. Conclusions: Insulin induces an endothelium-dependent relaxation of rabbit cavernous smooth muscles, which is mostly NO-independent, but seems to be related with prostaglandins or their metabolites. (Korean J Urol 2004;45:828-833)
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명순철,이신영,강군현,금은미,이무열,김세철 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.2
Purpose: This study was designed to investigate the effects of polyamines on rabbit seminal vesicular contractility. Materials and Methods: The polyamines; putrescine, spermidine and spermine, were added to deepithelized and precontracted seminal vesicle strips, with either 10-4M norepinephrine(NE), 10-4M acetylcholine(ACh) or 70mM KCl, in organ chambers to obtain cumulative concentration response curves. A whole cell mode patch clamp study was also performed to observe the effects of the polyamines on the L-type calcium channel activities. Results: The polyamines elicited concentration-dependent relaxations of the precontracted strips with the NE, ACh and KCl. The spermine showed the most potent relaxation response. Both extracellular and intracellular application of the spermine decreased the L-type calcium channel currents. Conclusions: Spermine more potently inhibited the seminal vesicle contraction than putrescine or spermidine, which suggests the polyamines may play a role in maintaining the basal tonicity of seminal vesicle in a flaccid state. The spermine-induced relaxation response seems to be related with an inhibition of the L-type calcium channel activities.
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