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Effect of Environmental Tobacco Smoke (ETS) on Atopic Dermatitis
Ok-hee Yi(이옥희),Ho-Jang Kwon(권호장),Ho Kim(김호),Mi-na Ha(하미나),Soo-Jong Hong(홍수종),Yun-Chul Hong(홍윤철),Jong-Han Leem(임종한),Joon-kong Sa(사공준),Chul-Gab Lee(이철갑),Su-Young Kim(김수영),Dong-mug Kang(강동묵) 한국환경독성학회 2010 한국독성학회 심포지움 및 학술발표회 Vol.2010 No.11
치아우식을 유발하는 Streptococcus mutans에 대한 억제효과를 가진 김치 유래 유산균 Latilactobacillus sakei subsp. sakei THYJ-15
정제용(Je-Yong Jung),유두나(Du-Na Yu),권예지(Ye-Ji Kwon),이은지(Eun-Ji Yi),Nguyen Thi Minh Trang(Nguyen Thi Minh Trang ),국무창(Moochang Kook),이태후(Tae-Hoo Yi) 한국유산균프로바이오틱스학회 2023 Current Topic in Lactic Acid Bacteria and Probioti Vol.9 No.1
Dental caries is an infectious disease that is caused by the interaction between the host, the diet, and a diverse microbial community. This study illustrated the anticariogenic effects of THYJ-15 against Streptococcus mutans, a major agent of dental caries. THYJ-15 was identified as Latilactobacillus sakei subsp. sakei through 16S rRNA sequencing, with a similarity of 99.72% to L. sakei subsp. sakei JCM 1157T. The cell-free supernatant of L. sakei subsp. sakei THYJ-15 observed MIC values of 10 mg/mL and MBC values of 20 mg/mL against S. mutans KACC 16833T. The cell-free supernatant of L. sakei subsp. sakei THYJ-15 showed significant inhibitory effects on biofilm formation, acid production and glucosyltransferases(GTFs) production against S. mutans. As a results, it was confirmed that L. sakei subsp. sakei THYJ-15 is a lactic acid bacterium possessing notable anticariogenic effects. Accordingly, L. sakei subsp. sakei THYJ-15 is expected to have great potential to be used as a basic substance for dental caries treatment caused by S. mutans.
간접흡연에 의한 소기도 및 폐실질의 초기 변화에 관한 초미세형태학적 검색
권건영,김영호,이병육,강유나,이상숙 啓明大學校 醫科大學 2001 계명의대학술지 Vol.20 No.2
단기간의 간접 흡연 노출에 의한 폐조직의 형태학적 변화를 알아보기 위해서 Sprague-Dawley종 흰쥐를 대상으로 흡연 용기 내에서 매일 1개비, 3개비 및 5개비씩 1개월 동안 노출시킨 후 소기도와 폐조직에서 초래되는 형태학적 변화를 광학현미경, 투과 및 주사현미경으로 검색하여 다음과 같은 결과를 얻었다. 광학현미경 소견으로 매일 1개비씩 간접 흡연에 노출된 군에서 폐실질에 뚜렷한 변화가 없었으나, 3개비 및 5개비씩 노출된 군에서 폐포 허탈과 폐포 배열에 불규칙한 변화를 뚜렷하게 볼 수 있었다. 폐포 내에는 갈색과립을 가진 폐포대식세포수가 증가하였다. 투과전자현미경 관찰에서 호흡세기관지 점막에 Clara 세포의 형태가 다양하면서 세포 표면에 미융모 소실로 편평화를 보였다. 폐포 허탈이 야기된 폐실질 주위로 폐포대식세포 수가 3개비 및 5개비의 간접 흡연 노출 군에서 더욱 증가하였고 이들은 모두 활발한 탐식을 보였다. 5개비 간접 흡연 노출 군에서 폐포상피세포의 손상이 국소적으로 보였다. 주사전자현미경 관찰에서 3개비 및 5개비 노출 군에서 폐포 허탈이 현저하면서 Clara세포의 형태가 불규칙하였다. 폐포관, 폐포강의 확장과 폐포벽 pore의 직경이 불규칙하게 확장되었으며, 5개비 노출 군에선 더욱 현저하였다. 이상의 실험 결과로 3개비 및 5개비의 간접 흡연 노출 군에서 호흡세기관지염의 초기병변과, 폐포관 및 폐포강의 확장과 폐포 허탈 등 폐실질의 변화를 볼 수 있었으며, 이들 소견은 간접 흡연에 의해 초래된 폐실질의 초기 손상으로 생각하였다. Cigarette smoking induces small airway diseases and deterioration in the lung function, and progresses to pulmonary parenchymal alteration. Early respiratory bronchiolitis and pulmonary parenchymal alteration were produced in Sprague-Dawley rats by daily exposure of sidestream cigarette smoke for one month, using a smoking chamber designed by authors. Experimental group A (n = 5) was sacrificed after smoke of one cigarette/day, group B (n = 5) with three cigarettes/day, and group C (n = 7) with five cigarettes/day for one month. The early changes of small airway and pulmonary parenchyma were examined by light microscope, transmission and scanning electron microscopes. Under light microscope, there were multifocally alveolar collapses, dilatation of respiratory bronchioles, alveolar ducts and alveolar spaces, and increase in number of brown-pigmented alveolar macrophages in alveoli around the respiratory bronchioles. Under transmission electron microscope, irregularly shaped Clara cells with decreased number of secretory granules, collapse of alveolar walls, and mild injury of type I and II epithelial cells were seen. Under scanning electron microscope, scattered foci of alveolar collapse, irregular dilatation of alveolar ducts, alveolar spaces and interalveolar pores (pores of Kohn), and irregular thickening of alveolar septa around the small airway were observed. We, therefore, concluded that sidestream smoke induced an early phase of respiratory bronchiolitis, dilatation of respiratory bronchioles and alveolar ducts, and mild remodeling of pulmonary parenchymal structure.
폐암 발생 용접공의 유해물질 노출 평가 및 폐암 원인에 관한 고찰
신용철,박정선,최정근,이나루,이광용,권은혜,정호근,박승현,이용학,유기호 한국산업위생학회 2000 한국산업보건학회지 Vol.10 No.1
The purpose of this case study is to report a case of lung cancer with exposure to welding fumes of welders in Korea and to demonstrate the causal relationship with exposure to welding fumes, especially with nickel and hexavalent chromium. The case is 47 years old, and had been engaged in welding, gas cutting, grinding and goosing on mild, stainless steel and nickel steel for 11 years from 1982 to 1993, and have been engaged in cleaning steel rollers with a cleaning oil in the same work shop since 1993. The level of welding fume exceeded the occupational exposure limit of 5㎎/㎥ established by the Korean Ministry of Labor and American Conference of Government Industrial Hygienists (ACGIH). Especially, detectable hexavalent chromium and nickel was generated during welding, gousing on stainless and nickel steel. However, there was no ventilation systems(local and dilution) and no personal protection. There is several evidence that the past (1983-1993) exposure would be higher than the present. In conclusion, the lung case could be associated with his task including welding, gousing, and this association could be attributed to carcinogenic potential of the nickel and chromium in the fume.