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흰쥐의 직장에 X-선조사와 Cis-Dichlorodiammineplatinum(Ⅱ)의 효과에 관한 실험적 연구
구혜수,이경자 梨花女子大學校 醫科大學 醫科學硏究所 1992 EMJ (Ewha medical journal) Vol.15 No.3
The effects of radiation and Cis dichlorodiammineplatinum(Ⅱ) (Cis-DDP) were assessed in rectum of rats by histopathological changes. Rats were exposed to single doses of X ray(6~10 Gy) without or with Cis-DDP(2.5㎎/㎏). In combined group, Cis-DDP was given 30 minntes before or immediately after irradiation. Cis-DDP alone showed inflammatory cell infiltration and increased goblet cells in the mucosa and edema and fibrosis of submucosa with vascular sclerosis. With increased radiation dosage. such changes were aggravated. Necrosis of muscle layer developed 8 Gy irradiation. In groups with combination treatment of X-ray and Cis-DDP. changes of mucosa and submucosa were not significantly different from radiation alone group, but necrosis of the muscle layer was developed in 6 Gy combination group and degree was more severe in 8 and 10 Gy combination group compared to radiation alone group. There was no difference according to the timing of Cis DDP administration before or after irradiation. This result suggests Cis DDP enhance the radiation effect on the rectum of rats and enhancement ratio was 1.3 as the endpoint was necrosis of the muscle layer.
Sonography of Kimura’s Disease in the Groin
구혜수,양달모,김현철,김상원,박소영,김교영 대한초음파의학회 2012 ULTRASONOGRAPHY Vol.31 No.3
Kimura’s disease is a rare chronic inflammatory disorder mimicking a malignant tumor. It usually occurs in the head and neck regions, but occasionally shows up in the groin. A gray-scale groin sonograph showed a lobulated hypoechoic mass. Color Doppler sonography revealed the paucity of blood vessels within the mass.
구혜수,박재옥,신중련,이덕용,정순미 이화여자대학교 의학회 1972 梨花醫學會誌 Vol.- No.4
24 hour's urines were collected from the 66 women medical students and vari?? components were analyzed and results were as follows; total volume 1,269.7ml, pecific gravity 1.0195, pH6.3, titratable acidity 223, Creatinine 1.48 gm, Urinary Nitrogen 12.7gm, Uric acid 0.59gm, Chloride(as Nacl)14.5gm, Sodium 6.62gm, Potassium 1.89gm, Calcium 0.18gm, Phosphorus 272mg. The results were compared with those of others.
Myofibrillar Myopathy - A Case Report -
구혜수,김지영,정은혜,박기덕 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.4
Myofibrillar myopathies (MFMs) are a genetically or clinically heterogeneous group of diseases that are characterized by focal myofibrillar dissolution associated with accumulation of myofibrillar degradation products and ectopic expression of multiple proteins. Since MFMs show morphologically distinct features but consist of genetically and clinically heterogeneous diseases, muscle biopsy is important for the diagnosis. A 20-year-old man complained of progressive weakness and atrophy of both legs for two years. He had a dysmorphic face and short stature. The light microscopic examination of his muscle biopsy showed mixed myopathic and neurogenic changes. Many myofibers with multiple clusters of blue red rod-like structures and cytoplasmic inclusions were noted. Immunohistochemistry showed a focal positive reaction in sarcoplasm to desmin and myotilin antibodies. An electron microscope study revealed variable abnormalities of myofibrillar structures. To the best of our knowledge, this is the first reported case of MFM with pathology findings in Korea.
구혜수,정하린,강한나,김형경,배지윤,송동은,조민선,성순희,한운섭 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.3
Background : This study was done to see if there were correlations between anatomic and molecular parameters such as microvessel density (MVD), lymphatic vessel density (LVD), and vascular endothelial growth factor receptor (VEGFR)-3 expression and various clinical parameters for papillary thyroid carcinomas of size > 1.0 cm (PTCs) and size ≤ 1.0 cm (papillary thyroid microcarcinomas, PTMCs). PTMCs were divided into two subgroups (0-5 mm and 6-10 mm). Methods : We analyzed 197 thyroid carcinomas including 113 PTCs and 84 PTMCs. Tissue samples form 30 patients from each group matched for clinical characteristics were selected for immunostaining. Results : Although PTCs and PTMCs showed significant differences in clinical characteristics, they did not show significant difference in MVD, LVD, or VEGFR-3 expression. There was a significantly higher LVD in the PTMC subgroup with the larger tumors but no difference in clinical characteristics. LVD was higher in patients > 45 years old (more apparent in the PTC group) and LVD had suggestive correlations with multicentricity and extrathyroidal extension depending on analytic conditions. Conclusions : Since LVD showed variable correlations with clinical variables for papillary carcinoma of the thyroid depending on analytic conditions, the individually planned treatments based on overall clinicopathological factors are advised.
구혜수,박재옥,신중련,이덕용,정순미 이화여자대학교 의과대학 1972 梨花醫學誌 Vol.- No.4
24 hour's urines were collected from the 66 women medical students and vari?? components were analyzed and results were as follows; total volume 1,269.7ml, pecific gravity 1.0195, pH6.3, titratable acidity 223, Creatinine 1.48 gm, Urinary Nitrogen 12.7gm, Uric acid 0.59gm, Chloride(as Nacl)14.5gm, Sodium 6.62gm, Potassium 1.89gm, Calcium 0.18gm, Phosphorus 272mg. The results were compared with those of others.
구혜수,김형경,정하린,강한나,배지윤,송동은,조민선,성순희,한운섭 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.2
Background : This study was done to obtain comprehensive data on changes in the structural components of the enteric nervous system in pediatric patients with intestinal pseudo-obstruction (IPO). We evaluated routinely processed, in formalin-fixed tissues by quantitative morphometric analysis. In addition, we used formalin-fixed tissue to explore the possibility of using previously proposed diagnostic criteria to evaluate frozen serial sections for intestinal neuronal dysplasia (IND) type B and hypoganglionosis. Methods : We analyzed data for 19 IPO cases. Morphometric analysis for quantification of ganglia and ganglion cells (GCs) was done for the myentric and the submucous plexus. In addition, we determined the presence of immature GCs and the distribution of nerve fibers and interstitial cells of Cajal (ICC). Results : Nine patients showed combined hypoganglionosis, IND, and decreased ICC; others showed various combinations of these. Several morphometric factors were significantly different between patient groups as well as being different than the control group. Conclusions : Our pediatric IPO cases showed extensive overlapping of pathological findings. And the findings suggest the utility of using previously proposed morphometrically measured factors in multiple frozen sections as diagnostic criteria for IND type B and hypoganglionosis in formalin-fixed tissue.