Clinical Experience with 3.0 T MR for Cardiac Imaging in Patients: Comparison to 1.5 T using Individually Optimized Imaging Protocols

고정민,정정임,이배영 대한자기공명의과학회 2013 Investigative Magnetic Resonance Imaging Vol.17 No.2

Purpose : To report our clinical experience with cardiac 3.0 T MRI in patients compared with 1.5 T using individually optimized imaging protocols. Materials and Methods: We retrospectively reviewed 30 consecutive patients and 20 consecutive patients who underwent 1.5 T and 3 T cardiac MRI within 10 months. A comparison study was performed by measuring the signal-to-noise ratio (SNR), the contrast-to-noise ratio (CNR) and the image quality (by grading each sequence on a 5-point scale, regarding the presence of artifacts). Results: In morphologic and viability studies, the use of 3.0 T provided increase of the baseline SNRs and CNRs, respectively (T1: SNR 29%, p < 0.001, CNR 37%, p < 0.001; T2-SPAIR: SNR 13%, p = 0.068, CNR 18%, p = 0.059; viability imaging: SNR 45%, p = 0.017, CNR 37%, p = 0.135) without significant impairment of the image quality (T1: 3.8 0.9vs. 3.9 0.7, p = 0.438; T2-SPAIR: 3.8 0.9 vs. 3.9 0.5, p = 0.744; viability imaging: 4.5 0.8 vs. 4.7 0.6, p = 0.254). Although the image qualities of 3.0 T functional cine images were slightly lower than those of 1.5 T images (3.6 0.7 vs. 4.2 0.6, p < 0.001), the mean SNR and CNR at 3.0 T were significantly improved (SNR 143% increase, CNR 108%increase, p < 0.001). With our imaging protocol for 3.0 T perfusion imaging, there was an insignificant decrease in the SNR (11% decrease, p = 0.172) and CNR (7% decrease, p = 0.638). However, the overall image quality was significantly improved (4.6 0.5 vs. 4.0 0.8, p = 0.006). Conclusion: With our experience, 3.0 T MRI was shown to be feasible for the routine assessment of cardiac imaging.

인간각질형성세포에서 알파망고스틴의 자외선B 의존적 산화적스트레스에 대한 세포보호 효과

고정민 대한피부미용학회 2015 대한피부미용학회지 Vol.13 No.6

One of subtypes in ultraviolet (UV), UVB, has been reported that the most powerful factors causing photoaging and DNA lesions. Finding and developing both cost-effective and efficient materials are the urgent issues to protect the skin from UVB-induced damages. Alpha-mangostin (α-mangostin), the first xanthone isolated from Garcinia mangostana (mangosteen), has been studied for anti-inflammation and antioxidant properties. The purpose of this study to investigate effects of α-mangostin in HaCaT, keratinocyte against UVB radiation. To evaluate effects of α-mangostin upon UVB-induced cytotoxic damages, watersoluble tetrazolium salt (WST-1) assay, flow Cytometry analysis, qunatitative real-time PCR (qRT-PCR), and senescence associated β-galactosidase assay (SA-β-gal assay) were performed. Pretreatment of α-mangostin was verified protective effects on UVB-induced proliferative restrain, apoptotic cell death and senescence, in HaCaT keratinocytes. These results indicated the protective effects of α-mangostin against UVB, and suggest as a cosmeceutical ingredient.

Partial Tetrasomy of Chromosome 22q11.1 Resulting from a Supernumerary Isodicentric Marker Chromosome in a Boy with Cat-eye Syndrome

고정민,김준범,배기수,윤전노,박상진 대한의학회 2010 Journal of Korean medical science Vol.25 No.12

The 22q11 region has been implicated in chromosomal rearrangements that result in altered gene dosage, leading to three different congenital malformation syndromes:DiGeorge syndrome, cat-eye syndrome (CES), and der(22) syndrome. Although DiGeorge syndrome is a common genomic disorder on 22q11, CES is quite rare, and there has been no report of Korean CES cases with molecular cytogenetic confirmation. In this study, we present the phenotypic and genetic characteristics of a 3-month-old boy with CES. Clinical findings included micropthalmia, multiple colobomata, and renal and genital anomalies. Cytogenetic analyses showed the presence of a supernumerary marker chromosome, which was identified as a bisatellited and isodicentric chromosome derived from an acrocentric chromosome. The results of array comparative genomic hybridization and fluorescence in situ hybridization studies confirmed the karyotype as 47,XY,+mar.ish idic(22)(q11.1)(D22S43+).arr 22q11.1(15,500,000-15,900,000)x4, resulting in a partial tetrasomy of 22q11.1. To the best of our knowledge, this is the first report in Korea of CES confirmed by cytogenetic and molecular cytogenetic analyses.

엘레강스 이미지를 이용한 네일 아트 디자인 연구

고정민,김주섭 한국피부과학연구원 2012 대한피부미용학회지 Vol.10 No.2

This study aims at applying elegance image to nail art assessed as an area of art, and resurfacing woman’s beauty. The article explored approaches exemplifying the photos of elegance image, looking into correlation of nail art design scope and expression, introducing elegance image into the motive of nail art design, and researching into and developing nail art as a fi eld of design with aesthetic beauty and artistry . This study could fi nd that proper use of soft color or grayish color creates sensitive and elegant feeling, and arranging similar colors expresses a typical elegance image. Elegance image is mixed with refined, gracious, and luxurious image, giving relatively simple and gentle feeling, which can be expressed in nail art design in a various technique and form. Thus producing nail art design is signifi cant in harmonious production of color and image,and various studies on image expression is thought to steadily proceed.

한류문화와 관광

고정민 한국문화관광연구원 2012 한국관광정책 Vol.- No.49

Factors Influencing Over-the-top Services Adoption: Multinomial Logistic Regression between Non-adopters, Free Service, and Paid Service Adopters

고정민,장병희 사이버커뮤니케이션학회 2023 사이버 커뮤니케이션 학보 Vol.40 No.1

Global content providers have faced a fundamental problem of who and why they do not adopt OTT services. We investigate the adoption behavior of OTT consumers by segmenting them into non-adopters, free OTT service adopters, and paid OTT service adopters. Using the Korea Media Panel Survey in 2019 (N = 8,011), we conduct multinomial logistic regression analysis to predict free service adopters (n = 3,164) and paid OTT service adopters (n = 335) based on non-adopters (n = 4,512). This study demonstrated that demographic variables predict OTT service adopters. Among the dimensions of consumer innovativeness, hedonic dimension was a strong predictor of free and paid OTT service adopters. The lower the social dimension, the higher the probability of adopting paid OTT services. This suggests that OTT is an entertainment-oriented service that shows a willingness to pay to gain pleasure in individual free time rather than meaningful rewards. Also, this study provides important insights to be considered in literature on innovative service adoption and global OTT marketers by identifying the low privacy awareness and new media effect toward OTT adoption.

Association between Bone Mineral Density and LDL Receptor-Related Protein 5 Gene Polymorphisms in Young Korean Men

고정민,정민희,홍정수,박형주,장재석,신형두,김신윤,김기수 대한의학회 2004 Journal of Korean medical science Vol.19 No.3

Recently, It has been reported that the LDL receptor-related protein 5 (LRP5) reg-ulates bone formation, and that mutations of the gene cause osteoporosis-pseudo-glioma syndrome or high bone mass phenotypes. However, the mutations cannot explain a genetic trait for osteoporosis in the general population because of their rarity. From 219 Korean men aged 20-34 yr, we looked for six known polymorphisms causing amino acid changes in the LRP5 coding region, and investigated their asso-ciation with bone mineral density (BMD) at the following anatomical sites: lumbar spine (L2-L4) and the left proximal femur (femoral neck, Ward’s triangle, trochanter and shaft). We found that the Q89R polymorphism was significantly associated with BMD at the femoral neck and Ward’s triangle (p=0.004 and <0.001, respectively). However, after adjusting for age, weight and height, a statistically significant associa-tion only occurred at the Ward’s triangle (p=0.043), and a marginal association was observed at the femoral neck (p=0.098). No A400V, V667M, R1036Q and A1525V polymorphisms were found, and no statistically significant association was found between the A1330V polymorphism and BMD at any sites. Although we failed to demonstrate a clear association between the LRP5 polymorphism and peak bone mass in young men, the present study suggests that larger-scale studies on the Q89R polymorphism need to be performed.

미술관 전시에서의 사진 촬영이 체험 만족도에 미치는 영향

고정민,신한나,최지원 한국예술경영학회 2019 예술경영연구 Vol.0 No.49

This study aims to find out how the photographing affects the satisfaction of visitor experience in the art gallery. We surveyed the visitors who visited the exhibition hall. In order to see if the selfie photographs positively affect the visitor satisfaction level, one-way ANOVA was conducted and the mediating effect of the flow and the moderating effect of narcissistic tendency and involvement was examined. As a result of study, First, in the relationship between photography and satisfaction, the group who took a photo but did not take a self-shot showed higher satisfaction than the group who did not take a photo and self-shot in the exhibition area. This result shows that photographing the art work in the exhibition hall gives experience-based satisfaction to the visitors, but self-shot does not show positive effect on the satisfaction. Second, the hypothesis that the flow degree will play a mediating role of the visitor's experience-based satisfaction in the relationship between art work photo-shot and self-shot type in exhibition hall was rejected. Third, the positive effect of involvement was shown only in the groups that did not take self-shot but took pictures in the exhibition hall. This shows that the satisfaction of the self-shot visitor is not affected by the degree of involvement of art. The results of this study are expected to help determine the policy for permission to take photographs in art galleries. 본 연구는 미술관 전시장 내에서 사진 촬영이 관람객 체험 만족도에 어떠한 영향을미치는지를 파악하기 위한 목적을 가진다. 이를 위해 전시장을 방문한 관람객들을대상으로 설문조사를 실시하였다. 셀피, 작품사진 촬영이 관람객의 체험 만족도에긍정적으로 작용하는지를 알아보기 위해 일원분산분석을 하였고, 관여도 및 나르시시즘 성향에 따른 조절효과와 몰입의 매개효과를 검증하였다. 분석결과, 첫째, 사진촬영과 만족도의 관계에서, 사진 촬영은 했지만 셀피 촬영을 하지 않은 집단은 전시장 내에서 사진과 셀피 촬영을 모두 하지 않은 집단에 비해 관람객의 만족도가높게 나타났다. 이 결과는 작품에 대한 사진 촬영은 관람객들에게 체험을 통한 만족감을 주지만, 셀피 촬영을 한다고 해서 만족감에 긍정적으로 작용하는 것은 아니라는 것을 보여준다. 둘째, 몰입도는 전시장 내에서 사진과 셀피 촬영 유형과 관람객의 체험 만족도의 관계에서 매개역할을 할 것이라는 가설은 모두 기각되었다. 셋째, 전시장 내에서 사진 촬영은 했지만 셀피 촬영은 하지 않은 집단과 전시장 내에서 사진과 셀피 촬영을 모두 하지 않은 집단에 따른 체험 만족도 차이에서만 관여도의 정(+)의 조절효과가 나타났다. 이는 셀피를 찍는 관람객들은 미술에 대한 관여도에 따라 만족도가 영향을 받지 않는 것을 의미한다. 본 연구의 결과는 미술관의 전시장 내 사진 촬영의 허용에 대한 정책을 결정하는데 도움이 될 것으로 기대한다.

한류현상을 접근하는 연구영역에 관한 연구

고정민 가톨릭대학교 한류대학원 한류지식센터ㆍ문화비즈니스연구소 2014 한류비즈니스연구 Vol.1 No.-

항Hu항체, 소세포폐암과 연관된 신생물딸림무도증

고정민,김태영,권형주,홍진용 대한신경과학회 2019 대한신경과학회지 Vol.37 No.1