닛셀정에 대한 헤파필연질캡슐의 생물학적 동등성 평가

고인자,지상철,Ko, In-Ja,Chi, Sang-Cheol 대한약학회 2004 약학회지 Vol.48 No.6

Biphenyl dimethyl dicarboxylate (DDB) has been used for the treatment of chronic viral hepatitis B and drug-induced hepatitis through the inhibition of lipid peroxidation and c ovalent binding of drug metabolites to lipids of microsomes. The bioequivalence of two DDB products was evaluated according to the guidelines of KFDA. The test product was Hepaphil soft capsule(R) made by KMS Pharm. Co. Containing 3 mg DDB and the reference product was Nissel tablet(R) made by Taerim Pharm. Co. Containing 25 mg DDB. Twenty healthy male subjects, 25.4(22~30) years old and 66.7(54~77)kg, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets or two capsules were orally administered, blood was taken at predetermined time intervals and the concentration of DDB in plasma was determined using a validated HPLC method with UV detector. Two pharmacokinetic parameters, $AUC_t$ and $C_{max}$, were calculated and analyzed statistically for the evaluation of bioequivalence of the two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90% confidence intervals of $AUC_t$ and $C_{max}$ were log 0.91~log1.00 and log 1.05~log 1.15, respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating that Hepaphil soft capsule is bioequivalent to Nissel tablet.

정지장면의 연속 프레임 영상 간 통계에 기반한 영상분할

서수영,고인철,Seo, Su-Young,Ko, In-Chul 한국공간정보학회 2010 한국공간정보학회지 Vol.18 No.3

본 연구는 정지장면의 연속영상간 각 픽셀위치에서 일어나는 통계적 특성을 활용하여 영상을 분할하는 기법을 제안한다. 공간정보의 획득과 분석에서 디지털 영상 처리 기법의 활용은 아주 중요한 의미를 가진다. 특히 디지털 영상의 영역 구분을 위해 다양한 영상 분할(image segmentation) 기법들이 활용되고 있다. 본 연구에서는 선행 연구한 연속프레임 영상의 분광학적 특성 분석의 결과를 바탕으로 연속 프레임 간 Randomness를 활용한 이미지 분할 방법을 제안하였다. 우선 연속 프레임 간 각 화소에 통계학적인 분석 방법을 적용하여 각 화소의 평균과 표준편차 값을 구하고, 이를 통하여 대상 영상에서 가장 신뢰할 만한 화소들을 찾아 씨앗 점(seed point)을 결정하였다. 그리고 이 씨앗 점들을 시작으로 이웃 화소 간 T-test를 실시하였으며, 이를 기반으로 영역 성장(region growing)의 개념을 적용하여 영상을 분할 할 수 있는 기법을 연구하였다. 제안방식의 성능을 검증하기 위하여 실험을 통하여 기존의 방식과 비교분석을 수행하였다. 이러한 실험의 결과 영상분할에서 영상의 단일 프레임을 활용한 것보다 연속 프레임을 활용한 경우가 유리함을 확인 할 수 있었다. This study presents a method to segment an image, employing the statistics observed at each pixel location across sequential frame images. In the acquisition and analysis of spatial information, utilization of digital image processing technique has very important implications. Various image segmentation techniques have been presented to distinguish the area of digital images. In this study, based on the analysis of the spectroscopic characteristics of sequential frame images that had been previously researched, an image segmentation method was proposed by using the randomness occurring among a sequence of frame images for a same scene. First of all, we computed the mean and standard deviation values at each pixel and found reliable pixels to determine seed points using their standard deviation value. For segmenting an image into individual regions, we conducted region growing based on a T-test between reference and candidate sample sets. A comparative analysis was conducted to assure the performance of the proposed method with reference to a previous method. From a set of experimental results, it is confirmed that the proposed method using a sequence of frame images segments a scene better than a method using a single frame image.

증강현실기반의 지리 학습 콘텐츠 활용 사례연구

이석준 ( Seok Jun Lee ),고인철 ( In Chul Ko ),정순기 ( Soon Ki Jung ) 한국지리정보학회 2011 한국지리정보학회지 Vol.14 No.3

최근 정보통신기술의 발전과 더불어 geographic information system(GIS)의 사용이 점차 일반화되고 그 응용분야와 활용범위가 확대되고 있다. 특히, 지리정보 관찰과 학습에서도 GIS의 활용은 긍정적인 효과가 기대되며, 2차원 시각 교보재인 사진이나 영상물에 비해 보다 사실적으로 지리적 특성을 파악하는데 도움이 될 것이다. 다소 복잡한 지형정보의 효과적인 시각화는 학습자로 하여금 지리정보 이해를 도울 뿐만 아니라, 지리적 정보를 파악하고 분석하는 능력을 키울 수 있다. 본 논문에서는 지리 학습에서 활용할 수 있는 학습보조자료 개발을 목표로 증강현실기술을 이용한 다양한 지형정보 가시화 기법과 사례를 연구하였다. 더불어 증강현실기반의 지리 학습을 위해, 기존에 구축된 GIS 데이터의 가공과정과 가공사례를 소개함으로써 3차원 지리정보의 효과적 가시화를 위해 증강현실 기술을 적용할 가치가 있음을 나타내었다. Recently, the geographic information system(GIS) is generally used in various fields with the development of information and communication technology, with expansion of its applications and utilization scope. Especially, utilizing GIS is expected to have positive effects on the geography learning and more helpful for the geographic information observation compared to the picture or 2D based media. The effective visualization of complex geographic data does not only take realization of its visual information but also increases the human ability in analysis and understanding to use the geographic information. In this paper, we examine a method to develop the geography learning contents based on the technology with augmented reality and GIS, and then we have a case study for various kinds of visualization techniques and examples to use in geography learning situation. Moreover, we introduce an example of the manufacturing process from the existing GIS data to augmented reality based geography learning system. From the above, we show that the usefulness of our method is applicable for effective visualization of the three-dimensional geographic information in the geography learning environment.

장애인 인식개선교육 프로그램 개발 방안

김용탁(Kim, Yong-tak),김정연(Kim, Jeong-yeon),고인철(Ko, In-chul) 한국장애인고용공단 고용개발원 2016 기본과제보고서 Vol.2016 No.-

재배지역별 청양고추의 품질 특성

황인국(In Guk Hwang),김하윤(Ha Yun Kim),이준수(Junsoo Lee),김행란(Haeng-Ran Kim),조명철(Myeoung-Cheoul Cho),고인배(In Bae Ko),유선미(Seon Mi Yoo) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.9

본 연구에서는 우리나라의 청양고추를 13개 지역에서 노지재배된 것을 채취하여 재배지역별 품질 특성을 비교 분석하였다. 일반성분의 경우 단백질함량은 12.74~19.98%, 지방함량은 4.54~7.17%, 회분함량은 6.07~9.81% 범위로 넓은 분포를 보였다. 무기성분 함량은 지역별 차이를 보였지만 주요 무기성분은 K이었다. pH 및 총산도는 각각 4.86~5.26 및 2.10~4.25% 범위였다. 청양고추의 유리당은 fructose 및 glucose가 주요 유리당으로 검출되었고 각각 8.55~17.06% 및 3.25~10.47% 범위로 지역별 큰 차이를 나타냈다. 색도 중 a값은 28.89~37.12의 범위였고, ASTA값은 76.54~139.57의 범위로 a값에 비해 넓은 분포를 나타냈다. Capsaicin 함량은 100.27~261.54 mg%, dihydrocapsaicin 함량은 51.01~84.58 mg% 범위였고 capsaicinoid 함량은 11개 지역에서 200 mg% 이상의 함량을 보였다. 본 연구결과 청양고추는 재배지역에 따른 심한 함량 변이를 나타냈으며, 추후 다양한 품종을 대상으로 재배지역에 따른 품종 특성에 관한 추가 연구가 필요하다. This study was carried out to investigate the proximate composition, mineral content, pH, acidity, color, ASTA value, free sugar content, and capsaicinoid level of Cheongyang pepper (Capscium annuum L.) cultivated in 13 different regions. For proximate composition of Cheongyang pepper, protein, lipid, and ash contents showed wide ranges of 12.74~19.98%, 4.54~7.17%, and 6.07~9.81%, respectively. Calcium, magnesium, iron, sodium, and potassium are major minerals found in Cheongyang pepper. Further, pH, total acidity, a value, and ASTA value showed wide ranges of 4.86~5.26, 2.10~4.25%, 28.89~37.12, and 76.54~139.57, respectively. Free sugars were fructose (8.55~17.06%) and glucose (3.25~10.47%), but sucrose and maltose were not detected. Capsaicin and dihydrocapsaicin contents were in the range of 100.27 to 261.54 mg% and 51.01 to 84.58 mg%, respectively. Capsaicinoid contents were above 200 mg% for the 11 cultivation regions. According to our results, Cheongyang pepper may be affected by environmental conditions such as different cultivation region more than genotype.

세로자트정(파록세틴 20㎎)에 대한 삼천리파록세틴정의 생물학적동등성

고인자,지상철 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

Paroxetine. a potent and selective serotonine reuptake inhibitor. has been used for the treatment of depression, obsessive-compulsive disorder, panic disorder and social phobia. The bioequivalence of two paroxetine preparations was evaluated according to the guidelines of Korea Food & Drug Administration (KFDA). The test product was Samchullv Paroxetine tablet`' made by Samchullv Pharm. Co. and the reference product was Seroxat tablet made by GlaxoSmithKline. Twenty healthy male subjects. 22.4±2.6 years old and 63.8±4.2 kg. were divided into two groups and a randomized 2x2 cross-over study was employed. After one tablet containing 20 mg paroletine was orally administered. blood was taken at predetermined time intervals and the concentration of paroletine in plasma was determined using a validated HPLC method with fluorescence detector. Two pharmacokinetic parameters. AUCr and Cma.. were calculated and analyzed statistically for the evaluation of bioequivalence of two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90° 0 confidence intervals of AUCr and Cmax were log 0.84-log 1.16 and log 0.85-log 1.14. respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus. the criteria of the KFDA guidelines for the bioequivalence was satisfied. indicating that Samchullv Paroxetine tablet is bioequivalent to Seroxat tablet.