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Orientia tsutsugamushi감염 시 유발되는 마우스의 염증 반응
고영상 제주대학교 생명과학연구소 2000 제주생명과학연구 Vol.3 No.-
Early host defense mechanisms were examined in resistant (BALB/C) and susceptible (C3H/HeN) mice after intraperitoneal inoculation with Orientia tsutsugamushi strain Gilliam. In this study, I used semiquantitative reverse transcription-PCR to examine chemokine gene expression in resistant and susceptible mice following infection with strain Gilliam. The mRNAS for macrophage inflammatory protein 1 α/β(MIP- α/β ), monocyte chemoattractant protein 1 (MCP-1), gamma-interferon-inducible protein 10 (IP-10), tumor necrosis factor alpha (TNF- α), and RANTES were detected in susceptible mice. Peak expression of these chemokines was observed between 5 and 6 days after infection. However, gene expression of MIP-1 α/β , MIP-2, MCP-1, and TNF-α was not detected in resistant mice. The production of TNF-α is well correlated with the lethal infection model. Identification of various cytokines and chemokines changed in amount during infection provides important information relevant to unraveling the host defense mechanisms for natural resistance to infection.
Orientia tsutsugamushi에 감염된 인간 피부 미세혈관 내피세포의 산화 활성
고영상,Koh Young-Sang 한국미생물학회 2005 미생물학회지 Vol.41 No.3
Transcripts levels of superoxide dismutases increase slightly following infection of human dermal microvascular endothelial cells(HMEC-1) by the obligae intracellular bacterium Orientia tsutsugamushi, the causative agent of scrub typhus. In addition, fluorescence-activated cell sorter analysis demonstrates significant intracellular peroxide activity in infected cells within 5 hr after exposure to O. tsutsugamushi. Furthermore, infected cells experienced a significant depletion of glutathiones. These results support hypothesis that cells infected by this intracellular bacterium experience oxidant-mediated injury. Scrub typhus의 원인병원체인 Orientia tsutsugamushi에 감염된 인간 피부 미세혈관 내피세포(HMEC-1)에서 superoxide dismutase 유전자의 발현이 증가하였다. O. tsutsugamushi 접촉 후 5 시간 이내에 감염된 세포에서 세포내 peroxide 존재를 유세포 분석을 통하여 관찰할 수 있었다. 또한 감염된 세포는 세포 내 glutathione이 심하게 고갈됨을 관찰하였다. 이 결과들은 이 절대세포내 기생세균에 감염된 숙주세포가 산화-매개 손상 받음을 시사한다.
고영상,구자홍,김공수,Go, Yeong-Sang,Gu, Ja-Hong,Kim, Gong-Su 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.10
Leriche syndrome ia a common entity which causes ischemia of the lower extremities. Since the introduction of aortic resection and homograft replacement by Oudot in 1951, reconstructive procedures to restore distal blood flow by either endarterectomy or, later, with prosthetic graft have become standardized. Recently we experienced a case of Leriche syndrome. A 50 year-old male patient admitted with intermittent claudication, impotence, and symmetrical atrophy at lower extremities. Aortogram revealed complete obstruction at infrarenal abdominal aorta and Doppler sonogram revealed only minimal blood flow at left femoral artery.Successful surgical treatment was accomplished with endarterectomy at proximal left renal artery and a bypass from abdominal aorta at the level of both renal arteries to both external iliac arteries with bifurcated Gore-tex vascular graft. After bypass operation, we did palpate with arterial pulse at both popliteal artery.He was recovered without complication.
고영상,김공수,Go, Yeong-Sang,Kim, Gong-Su 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.10
Thoracic empyema is defined as purulent pleural effusion or effusion with positive bacteriology. Recently, the empyema has markedly decreased by developement of antibiotics, but empyemas following thoracotomy were occasionaly reported. During the period of January, 1985 to May,1991, 18 patients with postthoracotomy empyema have been treated in the Department of Thoracic and Cardiovascular Surgery of Chonbuk National University Hospital.There were 17 males and 1 female ranged from 18 years to 67 years of age. The underlying diseases of empyema were tuberculosis [50%], lung cancer [33.3%], esophageal cancer [11.1%],and aspergillosis with tuberculosis[5.6%]. In surgical procedures causing the empyema, there were lobectomy[38.9%], pneumonectomy[22.2%], decortication[16.7%], decortication & lobectomy[11.1%], and esophagectomy [11.1%]. Etiologic organisms in the pleural fluid were Pseudomonas [27.7%], S.aureus [16.7%], mixed infection [16.7%], K.pneumonia [5.6%], M.tuberculosis [5.6%], and no isolation [27.7%]. In 6 cases with BPF, completion pneumonectomy was performed in 1 case, and open thoracostomy in 5 cases. In 12 cases without BPF, closed thoracostomy was performed in 1 case, decortication in 2 cases, decortication & open thoracostomy in 2 cases, and open thoracostomy in 7 cases. In 6 cases with BPF, the fistulas were closed in 4 cases at follow up, the other 2 cases died from pulmonary insufficiency after completion pneumonectomy and open thoracostomy,respectively. In 12 cases without BPF, the empyema cavities were filled with expanded lungs and granulation tissues, except 1 case died from sepsis.