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급성 cadmium chloride 중독이 백서 심장 전도계 및 수축기능에 미치는 영향
김경수,이재웅,김순길,김정현,임헌길,이방헌,이정균,김진혁,김기순 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2
Cadmium is widely used in electroplating, plastic engineering and for manufacturing color pigment and nickel-cadmium batteries. As the chances of exposure to cadmium increase, cadmium poisoning is becoming one of the major problems in heavy metal toxicity not only in industrial workers but also in general populations. Not infrequently coronary artery disease, hypertension and cerebrovascular accidents are related to a chronic exposure to cadmium. Cadmium is known to decrease cardiac contractility and also to cause dilated cardiomyopathy as well as abnormalities in the cardiac conduction system. In most of previous studies on acute toxic effects of cadmium on the heart, Langendorff's heart preparations were routinely perfused with solutions containing varying amount of cadmium. Though employment of Langendorff's heart prepartion was ideal method for exploring the effect of cadmium per se, the route of cadmium administration was rather not physiological i.e., effect of cadmium toxicity in vivo could not be assessed. In the present study cadmium was administrated into the peritoneum of rats and animals were sacrificed in 1 hour to 5 days after cadmium administration. To observe the effects of acute cadmium poisonging on the cardiac conduction system and myocardial systolic function, Langendorff's heart preparations were made and the RR interval, AH interval, HV interval, systolic acortic pressure and maximal dP/ dT of aortic pressure were measured in these heart preparations. 1) The RR intervals were increased significantly only in 3 hours after cadmium administration. A significant increase in the RR intervals was observed in 3 hours after cadmium administration. 2) The AH intervals started to increase significantly in 1 hour, peaked in 3 hours and returned to normal in 6 hours after cadmium administration. 3) The HV intervals started to increase significantly in 3 hours, peaked in 6 hours and returned to normal in 24 hours after cadmium administration. 4) The aortic systolic pressures and miximal dP/ dT started to decrease in 1 hour, showed persistent marked decrease until 2 days and returned to normal in 5 days after cadimum administration. The present results indicate that the recovery time from acute cadmium poisoning is different between the conduction system and the moyocardium possibly due to differencesn action sites of cadmium and/or in distribution of calcium channels in the cardiac tissues.
김기순,이흥수,이용근 원광대학교 치의학연구소 1998 圓光齒醫學 Vol.8 No.1
Dental injuries are the most frequent type of orofacial injury sustained during participation in sports and most are preventable through wearing a well fitting mouth protectors. The major means used for the prevention of intraoral trauma in sports is the athletic mouth protectors. In 1962, a mandatory mouthguard rule was adopted in USA by the National Alliance Football Rules Committee. From that time, these measures proved successful in reducing the incidence of oral injuries. But in Korea, there are few reports on the fabrication or usage of mouth protectors. In this study, mechanical properties of mouth protector materials were evaluated, and these results can be used as basic data for the research of mouth protectors in Korea. Tensile, tear and compressive properties of three kinds of mouth protector materials were tested before and after thermocyling in acid added artificial saliva for 500 and 1,000 cycles. From this experiment, the following results were obtained. 1. Comparing the tensile strength of three materials before thermocycling, the tensile strength of SPO was significantly lower than that of B1O2.0 and B1O3.0(p<0.05). 2. The tensile strength of BIO was not changed significantly after thermocycling for 1,000 cycles. However, that of DOU was in decreasing trend and that of SPO increased significantly after thermocycling(p<0.05). 3. The tear strength of SPO was significantly higher than those of BIO and DOU in before-thermocycling condition(p<0.05). 4. The tear strength of B103.0 increased significantly after thermocyclig for 1,000 cycles(p<0.05). However, there was no significant change after thermocycling in all the other materials. 5. Comparing the compressive properties of the same material before and after thermocycling, the elastic modulus ratio, compression at maximum force and toughness increased significantly after thermocycling in most of the materials(p<0.05).
한국인 관상동맥성 심질환의 위험요인으로서 혈청지질에 관한 메타분석
김기순,김양옥,박종,박종구,김춘배,지선하,류소연,Kim, Ki-Soon,Kim, Yang-Ok,Park, Jong,Park, Jong-Ku,Kim, Chun-Bae,Jee, Sun-Ha,Ryu, So-Yeon 대한예방의학회 1999 예방의학회지 Vol.32 No.4
Objectives : To determine the relations between seven blood lipids such as total cholesterol(TC), triglyceride(TG), HDL-cholesterol(HDL), LDL-cholesterol(LDL), apolipoprotein A-1(Apo A1), apolipoprotein B(Apo B) and lipoprotein(a)(Lp(A)) and the coronary heart diseases(CHD), the quantitative techniques of meta-analysis were applied to studios of blood lipids and CHD in Koreans. Methods : We searched the Korean and the English literature published from 1980 to August, 1997 by manual search and bibliography review. Information on sample size, study design, participant characteristics(gender, age) and blood lipid levels were abstracted by reviewers using inclusion criteria. Estimates of the effect sizes of blood lipid levels on CHD in Koreans and corresponding 95% confidence intervals were calculated using random-effect models. Results : We identified 16 case-control studies to apply meta-analysis. The overall effect sizes for CHD were 20.3(95% CI: 14.23-20.22) in TC, 24.8(95% CI: 12.6-36.86) in TG, 15.16(95% CI: 3.99-26.33) in LDL, -3.48(95% CI: -5.79 - -1.17) in HDL, -9.78(95% CI: -16.98 - -2.58) in Apo-a1, 17.88(95% CI: 9.72-26.05) in Apo B and 18.95(95% CI: 17.88-20.02) in Lp(a). Conclusions : Our results suggested that seven blood lipids were significantly associated with CHD in Koreans. Well-designed and prospective studies between blood lipids and CMD in Koreans should be peformed.