장내 미생물과 췌담도계

류기현 대한소화기학회 2020 대한소화기학회지 Vol.75 No.5

The gut microbiota is part of the human body that is involved in body metabolism and the occurrence of various diseases. Detecting and analyzing their genetic information (microbiome) is as important as analyzing human genes. The core microbiome, the key functional genes shared by all humans, helps better understand the physiology of the human body. Information on the gut microbiome of a diseased person can help diagnose and treat disease. The pancreatobiliary system releases functional antimicrobial substances, such as bile acids and antimicrobial peptides, which affect the gut microbiota directly. In response, the gut microbiota influences pancreatobiliary secretion by controlling the generation and emission of substances through indirect signaling. This crosstalk maintains homeostasis of the pancreatobiliary system secretion and microbiota. Dysbiosis and disease can occur if this fails to work properly. Bile acid therapy has been used widely and may affect the microbial environment in the intestine. An association of the gut microbiota has been reported in many cases of pancreatobiliary diseases, including malignant tumors. Traditionally, most pancreatobiliary diseases are accompanied by infections from the gut microbiota, which is an important target for treatment. The pancreatobiliary system can control its function through physical and drug therapy. This may be a new pioneering field in the study or treatment of the gut microbiota.

스텐트 내 재협착에 시행한 Sirolimus 약물 방출 스텐트 삽입의 임상적 결과: 관상동맥 조영술에 의한 정량적 연구

류기현,배장호,김기영,현대우 대한심장학회 2006 Korean Circulation Journal Vol.36 No.2

Background and Objectives:There is little clinical data on the results of using Sirolimus-Eluting Stent (SES)for treating In-Stent Restenosis (ISR). We performed this study to evaluate the clinical outcomes for implantingSES for treating ISR in a real world hospital environment. Subjects and Methods:A total of 30 patients with32 ISRs (males: 73.3%, mean age: 60.2) (focal lesions: 21.9%, diffuse intra-stent lesions: 34.4%, proliferativelesions: 21.9%, total occlusions: 21.9%) were treated with SES after balloon predilation was performed. We evaluatedthe clinical results and the performed coronary angiography after 6 months. Results:All the procedureswere successful. The mean SES diameter and length were 3.0±0.3 mm and 27.1±5.5 mm, respectively, and themean acute gain was 2.42±0.38 mm. No in-hospital major adverse cardiac events (MACE) were observed. Twentyfive patients with 27 lesions (84.4%) underwent coronary angiography at their 6 month follow-up. The late lossand loss index were 0.41±0.56 mm and 0.18±0.22, respectively. The binary restenosis rate was 7.4% (2/27 lesions).The rate of target lesion revascularization was 3.7% (1/27 lesion). The incidence of MACE at 6 monthswas 3.3% (1/30 patient). Conclusion:Treating ISR with SES is a safe and effective procedure for reducing ISRwithout the occurrence of acute or sub-acute thrombosis. (Korean Circulation J 2006;36:121-125) 배경 및 목적: 본 연구는 Sirolimus 약물방출 스텐트가 스텐트 내에 발생하는 재협착을 억제한다는 것에 기초하여 스텐트 내 재협착 병변에 대한 치료에 있어서도 그 유용성과 안정성이 있는지를 확인하고자 하였다. 방 법: 과거 스텐트 내 재협착이 발생한 총 30명의 환자, 총 32개의 병변을 대상으로 하였고 병변의 특성에 따라 적절한 길이와 직경의 Sirolimus 약물 방출 스텐트를 삽입하였다. 이후지속적인 임상적 추적 관찰을 하였고, 6개월 이후의 관상동맥 조영술 추적검사를 통하여 기준 혈관직경, 최소 혈관 직경, late loss, loss index 등을 측정하였다. 결 과: 총 27개의 예에서 6개월 추적 관상동맥 조영술상 late loss 는 평균 0.41±0.56 mm, loss index는 평균 0.18±0.22이었고, 재협착 2예(7.4%)중 1예에 대해서 표적병변 재개통이시행 되었다. 임상적 추적 관찰 결과 주요심장사건은 없었다. 결 론: 본 연구에서 보듯이 Sirolimus 약물방출 스텐트는 스텐트내 재협착의 치료에 있어 유용성과 안정성이 있다고 볼 수있다.

≪족비십일맥구경≫의 질병관과 신체관

류기현,신민규,김수중,홍무창 대한침구의학회 2014 대한침구의학회지 Vol.31 No.1

Objectives : This study was aimed to investigate the view of disease and the view of body in Zubi Shiyi Mai Jiujing. Methods : With Zubi Shiyi Mai Juijing which was excavated from Mawangdui Han Dynasty tomb, we compared this document to other three documents excavated from Mawangdui. Results : 1. Zubi Shiyi Mai Jiujing is the oldest document about meridian pulse system excavated. 2. Zubi Shiyi Mai Jiujing sorted disease to Yang bing and san Yin bing . Yang bing is Zu san yang mai ’s disease and San yin bing is Zu san yin mai `s disease. Zu san yang mai `s diseases are mostly pain and swelling. 3. Zu san yin mai `s diseases are zu shao yin mai which is realated to pulsation and respiration, Zu tai yin mai which is realated to stomach and digestion, Zu jue yin mai which is related to excretion. 4. The most important symptom in Zubi Shiyi Mai zu san yin mai is Fan xin . It is realated to Zubi Shiyi Mai thinking Zu shao yin mai important about concept of body. Because in Zubi Shiyi Mai Zu tai yin mai and Zu jue yin mai does’nt come up to abdominal cavity so Zu shao yin mai is the only meridian which comes into body cavity. Conclusions : Zu san yin mai is related to heart and fan xin by Zu shao yin mai. In this perspective Zu shao yin mai is important in view of body of Zubi Shiyi Mai Jiujing.

Ultrastructure of Cymbidium Leaf Tissue Systemically Infected with Odontoglossum Ringspot Virus

류기현,김우갑,박원목,Ryu, Ki-Hyun,Kim, Woo-Kap,Park, Won-Mok Korean Society of Electron Microscopy 1994 Applied microscopy Vol.24 No.3

In ultrathin section of the tissue of odontoglossum ringspot virus (ORSV)-infected Cymbidium goeringii Reichenbach, ORSV particles appeared as bundles of irregular aggregates of various length which were called stacked plates or rounded plates. Virus particles were found in the cytoplasm in electron clear zones and they also found between cell wall and plasma membrane. They mainly clustered in parallel aggregates and sometimes oriented randomly. The X-bodies and paramural bodies were observed near the cell membrane and these contained vacuole-like cavities. The cell wall of infected tissue expanded largely. Some chloroplast in ORSV infected cell was irregular. No virus particle was present in mitochondria, nuclei, vacuoles, vesicles or other organelles. The plasmodesmata slightly enlarged, and virus-associated granules were present around it. 오돈토글로썸 윤문 바이러스(ORSV)에 감염된 한국 자생춘란(Cymbidium goeringii) 초박절편의 전자현미경 관찰에서 ORSV 입자들은 집적되거나 환형상 평면구조로 다양한 크기의 불규칙적인 응집된 다발상들이 관찰되었다. 바이러스 입자들은 원형질체에서 다수 존재하였고, 세포벽과 원형질막 사이에서도 존재하였으며, 이들은 주로 응집된 평행상과 불규칙적인 산재된 형태로 관찰되었다. X-체 및 paramural body는 원형질막 주변에 존재하였고 액포와 유사한 낭상 구조체에 싸여있었다. 바이러스에 감염된 조직의 세포벽은 확장되어 있었다. ORSV에 감염된 세포내 엽록체는 불규칙적인 모습을 보였다. 미토콘드리아, 핵, 액포, 소포 및 기타 세포내 소기관들내에서는 바이러스 입자를 볼 수 없었다. 원형질연락사(plasmodesmata)는 다소 확장되고, 바이러스 입자들이 이들 원형질연락사 주변에 존재하였다.

組織的 葛藤에 관한 硏究

柳基鉉 경희대학교 산업관계연구소 1983 産硏論叢 Vol.8 No.-

[초록없음]

기업집단의 인적요인분석과 경영사고의 혁신 : 한국재벌기업 그룹을 중심으로

류기현 고려대학교 경영대학 1978 경영논총 Vol.23 No.1

오이 모자이크 바이러스 As계통 외피단백질 유전자의 식물체 형질전환을 위한 발현벡타의 구축

류기현,박원목 한국식물병리학회 1995 Plant Pathology Journal Vol.11 No.1

Web-based DNA Microarray Data Analysis Tool

류기현,박희창 한국데이터정보과학회 2006 한국데이터정보과학회지 Vol.17 No.4

Since microarray data structures are various and complicative, the data are generally stored in databases for approaching to and controlling the data effectively. But we have some difficulties to analyze and control the data when the data are stored in the several database management systems. The existing analysis tools for DNA microarray data have many difficult problems by complicated instructions, and dependency on data types and operating system, and high cost, etc.In this paper, we design and implement the web-based analysis tool for obtaining to useful information from DNA microarray data. When we use this tool, we can analyze effectively DNA microarray data without special knowledge and education for data types and analytical methods.

오음리에서 사이공까지 : 구술을 통해 본 ‘파월전사’의 참전 과정과 현지 경험

류기현 재단법인 내일을여는역사재단 2021 내일을 여는 역사 Vol.80 No.-

해방 이후∼1970년대 초반 한국사 개설서의 ‘근대’ 규정 및 시대구분의 변화

류기현 서울대학교 인문학연구원 2018 人文論叢 Vol.75 No.1

This article examines how the ‘modern age (近代)’ was characterized in general Korean histories published from liberation in 1945 to the early 1970s. Generally, the Korean modern age is considered to have started in the late 19th century and ended in 1945. This kind of periodization on the Korean modern age had been constructed through the development of Korean historical scholarship and Korea’s political and social changes. The ‘modern age’ was absent in general history writings appearing from liberation to the early 1950s. General histories of this time describe Korean history as being consistently ‘stagnated’. Analyzing history from the late Chosun period, new general histories published from the mid-1950s to the early 1960s applied the concepts of ‘modern age’ and ‘modernization’ for the first time. The narrative focuing on ‘stagnation’ of Korean history partially persisted, but general histories of this period tried to describe Korean history from the viewpoint of development, defining some historical events including the Gapoh Reformation (甲午改革) as a starting point of the Korean modern age. General histories published from the mid-1960s to the early 1970s stress the socioeconomic dynamics of Korean history. They emphasize that the Korean society of the late Chosun period had the potential to independently achieve modernization. This kind of argument could come out as a result of the nationwide spread of moderniztion theory and the introduction of the ‘internal development theory’. General histories after the mid-1960s tried to depict the 18th-19th centuries Korea in the modern transition period as an active player prepared to respond to political and social challenges, and not just a passive one. 이 글은 해방 이후부터 1970년대 초반까지 출판된 한국사 개설서⋅ 통사에서 ‘근대’라는 역사적 시대를 규정⋅구획하는 양상을 통시적으로 탐구한다. 오늘날 우리가 일반적으로 19세기 중⋅후반을 기점으로하고 1945년 해방을 종점으로 잡는 근대라는 시대 규정은 근대 역사학도입 이래 처음부터 존재한 것이 아니라 한국사 연구의 전개과정, 한국의 정치적⋅사회적 변화에 따른 구성물이다. 해방 직후부터 1950년대 초반까지의 개설서에는 ‘근대’가 부재했다. 이 시기의 개설서들은 주로 정체론적 관점에서 한국사를 서술했다. 1950년대 중반부터 1960년대 초반에 나온 개설서들은 처음으로 ‘근대’ 및 ‘근대화’라는 개념을 동원해 조선후기-개항기의 역사를 서술했다.해방 직후 개설서의 정체론적 서사가 부분적으로 계속되는 가운데 이시기의 개설서들은 갑오개혁을 비롯한 몇 가지의 역사적 사건들을 한국의 근대 기점으로 제시하면서 발전과 변화라는 시각에서 한국사를파악하고자 했다. 1960년대 중반 이후부터 1970년대 초반에 나온 개설서는 조선 후기- 개항기에 이르는 시대의 사회경제적 역동성을 강조하고 이 시기의 한국 사회가 자생적 근대화를 이룩할 맹아를 지니고 있었음을 강조했다. 이는 근대화 담론의 전 사회적 확산 및 내재적발전론에 입각한 연구성과들이 축적된 것을 배경으로 한다. 60년대 중반 이후 개설서들은 한국이 근대 전환기에 단순히 수동적 존재가 아닌 적극적으로 근대에 대응하는 존재였음을 보이고자 했다.