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Current pharmacotherapies for atherosclerotic cardiovascular diseases
박종길,Goo Taeg Oh 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.3
Despite the introduction of statins for lowering LDL-C level, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death and morbidity worldwide. Combination therapies with statin and other lipid-lowering drugs, including ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, have unlocked additive benefits for treatment of ASCVD, but morbidity and mortality due to ASCVD remain high. New anti-inflammatory therapies have emerged for treatment and prevention of ASCVD to address these problems. Canakinumab neutralization of interleukin-1β (IL-1β) is the only verified therapy, and low-dose methotrexate holds promise due to its efficacy and safety for treatment of ASCVD. However, many agonistic and antagonistic candidates within inflammation pathways have failed to develop into useful drugs for ASCVD because of the complexity of the inflammatory process in atherosclerosis. In this review, we outline current and future pharmaceutical therapies for ASCVD in terms of lipid-modifying strategies and anti-inflammation treatments.
박종길,정우식,최효진,Park. Jong-Kil,Jung. Woo-Sik,Choi. Hyo-Jin 한국방재학회 2008 한국방재학회 학술발표대회논문집 Vol.2008 No.1
When it grasps a total property losses and relationship of damage factors, there is possibility of reducing the natural disaster damage which is a yearly repeated. Also, checking and supply to vulnerability should be presupposed. This study aims to find out a damage factor vulnerability using a natural disaster database by Park et al(2007). And added 2005 year data to database. Total 10 damage factors are deaths(person, including missing person) injury(person), victims(person), building(thousand), vessel(thousand), cultivated land(thousand), public facilities(thousand), others(thousand), total property losses(thousand). We analyzed of correlation analysis, ratio, population, area, regional character etc for damage factors.