Cancer therapy with plasmonic nanoparticles

박지호 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

In this talk, we introduce a ‘nanosystem’ comprised of two distinct nanoparticle populations (plasmonic nanoparticles and drug nanocarriers) that communicate and cooperate each other in vivo to amplify drug or imaging payload delivery. We construct a cooperative nanosystem consisting of two discrete nanomaterials. The first component is plasmonic gold nanorod “activators” that populate the porous tumor vessels and act as photothermal nanoantennas to specify tumor heating via remote near-infrared laser irradiation. We find that local tumor heating accelerates the recruitment of the second component: a targeted nanoparticle consisting of either magnetic nanoworms or doxorubicin loaded liposomes. This study demonstrates that the appropriate combination of nanomaterials currently under investigation in cancer therapy can significantly enhance therapeutic efficacy relative to the individual components. Site-specific photothermal heating of plasmonic gold nanorods can engineer the local tumor microenvironment to enhance the accumulation of therapeutic targeted liposomes, which increases the overall hyperthermal and chemotherapeutic tumor-destroying effects. Cooperative, synergistic therapies using plasmonic properties of the nanoparticles could significantly reduce the required dose of anticancer drugs, mitigating toxic side effects, and more effectively eradiating drug-resistant cancers.

Enhancing The Electrical Properties of The Semiconductor Compound by Applying Functionalized MWCNTs for Improved Dispersity

박지호,윤호규,임도현,남채윤,이주연,박명훈,김영빈 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.2

응급의료센터로 전원되는 요양병원 환자들의 특징

박지호,이대섭,민문기,류지호,이민지,조영모 대한응급의학회 2022 대한응급의학회지 Vol.33 No.1

Objective: This study was undertaken to assess the appropriateness of transfer of patients from a long-term care hospital to the emergency department (ED). Methods: We conducted a retrospective study in a Wide Regional Emergency Center in Gyeongsangnam-do between January 2019 and December 2019. The patients were divided into groups (direct visit, transferred from other hospitals, and transferred from long-term care hospitals [LTCHs]). The baseline characteristics, Korean Triage and Acuity Scale (KTAS), vital signs, length of stay, ED disposition, cost, clinical outcome, and instances of application of the “Act on decisions on life-sustaining treatment” were collected. Results: A total of 30,142 patients were enrolled during the study period. Twenty-one thousand, nine hundred and sixty-five patients were in the direct visit group, 7,057 patients were transferred from other hospitals, and 1,120 patients were transferred from LTCHs. Hospital admission was higher in cases of transfer from other hospitals and LTCHs (LTCHs, 63.8%; transferred from other hospitals, 64.1%, direct visit, 30.1%; P<0.001). Re-transfer and mortality in the ED were much higher (re-transfer: LTCHs, 11.0%; transferred from other hospitals 3.8%, direct visit 1.9%; P<0.001 and mortality in ED: 2.9%, 0.8%, 1.4%; respectively P<0.001). In the LCTH group after admission, mortality was higher (mortality: 16.2%, 5.4%, 7.1% for LTCH transfers and direct respectively; P<0.001). The implementation rate of the “Act on decisions on life-sustaining treatment”, the well-dying law, was higher in the LTCHs (26.6%, 12.5%, and 11.4% LTCH transfers, and direct respectively; P<0.001). Conclusion: In the LTCH group, re-transfer, mortality, and the implementation rate of the “Act on decisions on life-sustaining treatment” were higher than in the other groups.

Nanoparticle Platforms for Combined Photothermal and Photodynamic Therapy

박지호,Jeongmin Oh,Hwanjun Yoon 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.2

Phototherapy is a promising strategy for cancer treatment due to its selective and localized therapeutic effect by laser irradiation. Photothermal therapy damages malignant cells by using heat converted from light by an agent. On the other hand, photodynamic therapy uses photosensitizers that become cytotoxic upon irradiation with laser light at excitation wavelength. As singular treatment of each phototherapy showed some limitations, there have been significant efforts to enhance therapeutic effect by combining photothermal and photodynamic therapy. Here we review recent developments of nanoparticle platforms, in which inorganic nanostructures (photothermal therapy) are integrated with photosensitizers (photodynamic therapy) for combined phototherapeutic effect.

파라메타 변동에 강인한 유도전동기의 센서리스 벡터제어

우정인,김동완,김춘삼,박지호 東亞大學校 大學院 1999 大學院論文集 Vol.24 No.-

본 논문에서는 파라메타의 변동에 기인한 유도전동기의 성능저하를 개선하기 위한 강인한 센서리스 벡터제어를 제안한다. 동일차원 상태관측기를 구성하여 고정자전류와 회전자자속을 추정하고, 추정된 고정자전류와 회전자자속을 이용하여 속도 동정기를 구성한 후 회전자의 속도를 추정하여 Deadbeat 전류제어를 수행한다. 또한, 회전자속도의 추정에서 고정자전류 오차는 가변극배치 동일차원 상태관측기에 의해서 보상되며, 회전자자속 오차는 고정자전류를 입력으로 하고 회전자자속을 출력으로 하는 모델을 설정하여 이 모델에 파라메타 변동에 강인한 슬라이딩 관측기로 구성된 회전자자속 관측기를 부가한다. 이 회전자자속 관측기에서 회전자자속의 지령치와 추정값 사이의 오차를 보상하므로써 속도 동정기에 강인성을 부여하고, 정확한 Deadbeat 전류제어의 상태예측을 수행한다.

데이터베이스를 연계한 발전기 기동정지계획 어플리케이션 개발

박지호 慶北大學校 工科大學 電子技術硏究所 2003 電子技術硏究誌 Vol.23 No.-

데이터베이스를 연계한 발전기 기동정지계획 어플리케이션 개발

박지호,백영식 한국에너지학회 2003 에너지공학 Vol.12 No.4

본 논문은 전력계통에서 데이터베이스를 이용하여 발전기 기동정지계획 문제를 해결하는 발전비용에 의한 순위법을 제안한다. 발전기 기동정지계획의 정식화는 비선형 프로그래밍으로 표현된다. 하지만 대규모시스템에서 연속변수와 불연속변수를 동시에 최적화하는 것은 매우 어려운 문제이다. 발전비용에 의한 순위법은 발전시간의 발전기 운전비용에 기반한다. 본 논문에서는 제안한 알고리즘의 유효성과 경제적 효율성을 보여준다. This paper presents a Case-Sort method to solve the unit commitment problem using database in electric power systems. The formulation of the unit commitment nay be described as nonlinear mixed integer programming. However, it is hard to optimize a problem with discrete and continuous variables in a large-scale system at the same time. The Case-Sort method is based on the unit[MW]generation cost considered drive hour. Then, this paper shows effectiveness and economical efficiency of the proposed algorithm.

A Frequency Analysis of English Suffixes Based on Corpora

박지호 한국영어교육학회 2011 ENGLISH TEACHING(영어교육) Vol.66 No.1

This study aims to evaluate the practicality and reliability of the selection of derivational forms in Korean National Curriculum of English and examines the effect of the derivational regulation on government-authorized English textbooks used in middle and high school. The current National Curriculum issued the guideline for vocabulary use and selection in the textbooks and regulated derived words with 11 affixes not counted as new words (Chang, 2007). For the research, suffixed word list was developed based on high frequency 14,000 word families in BNC (Nation, 2004) and it was loaded onto the RANGE (Heatley & Nation, 2002). By using the developed suffix analysis tool, 28 newly revised textbooks from middle and high school curriculum were analyzed and three corpora including Brown Corpus, Open American National Corpus (OANC), and L2 corpus were investigated to suggest improved regulation of derivational forms. As a result, the guideline for the derivational regulation in the Curriculum is found to require more consistent research. For the purpose, four levels of graded suffixes were suggested for the future English curriculum revision.

Increased Carotid Intima-Media Thickness (IMT) in Hyperuricemic Individuals May Be Explained by Hyperhomocysteinemia Associated with Renal Dysfunction: a Cross- Sectional Study

박지호,송정수,최상태 대한의학회 2019 Journal of Korean medical science Vol.34 No.37

Background: Both hyperuricemia and hyperhomocysteinemia are known as main risk factors of cardiovascular diseases. There has been, however, no report on the relationship between carotid intima-media thickness (IMT) and homocysteine (Hcy) in hyperuricemic patients. This study aimed to investigate how hyperuricemia is associated with increased carotid IMT with a focus on hyperhomocysteinemia. Methods: This cross-sectional study included 1,222 patients who visited the Chung-Ang University Hospital Health Promotion Center from January 2013 to December 2015. The serum Hcy levels were estimated with a competitive immunoassay using the direct chemiluminescence method. The carotid IMT was measured by B-mode carotid ultrasonography. The definition of hyperuricemia was a serum uric acid level > 7.0 mg/dL for men or > 5.6 mg/dL for women, and hyperhomocysteinemia was defined as serum levels > 15 μmol/L. Results: The hyperuricemic patients showed significantly higher serum Hcy levels and lower estimated glomerular filtration rate (eGFR) than did normouricemic patients (13.39 ± 4.42 vs. 11.69 ± 3.65 μmol/L, P < 0.001; 85.16 ± 19.18 vs. 96.14 ± 16.63, P < 0.001, respectively). Serum Hcy level (odds ratio [OR], 1.050; 95% confidence interval [CI], 1.009–1.092) and fasting glucose level (OR, 1.018; 95% CI, 1.011–1.026) were independent risk factors for carotid plaque. In patients with hyperuricemia, the serum Hcy levels correlated with the eGFR (γ = −0.478, P < 0.001). The carotid IMT correlated with serum Hcy levels and eGFR (γ = 0.196, P = 0.008; γ = − 0.297, P < 0.001, respectively) but not with the serum lipid profile. Conclusion: These results suggest that renal function impairment in hyperuricemic patients may worsen carotid IMT by increasing serum Hcy levels.

Leveraging biological systems to improve nanomedicine

박지호 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0

Despite three decades of research, nanomedicines have yet to provide a benefit to patients. A fundamental limitation of current approaches to nanomedicine delivery is that they lack capabilities of targeting amplification and tissue penetration of therapeutic agents. This presentation will discuss our recent approaches to leveraging biological systems to improve nanomedicine. First, we have developed drug delivery nanosystems where two distinct nanomaterials work in concert within the bloodstream to amplifiy tumor targeting and improve therapy in vivo, whch was mediated by heat-sensitive biological responses. Secondly, we have developed drug delivery nanosystems where extracellular vesicles in the tumor microenvironment, which are the innate biological transport system, were engineered in situ to improve tumor penetration of therapeutic compounds and their therapeutic efficacy.