Paraquat 투여에 의한 가토 신장 변화에 대한 연구

이필호,김의한,강상균 순천향대학교 1992 논문집 Vol.14 No.4

To investigate the effect of Paraquat(PQ)on the kidney, Parquat was injected at dose of 10,20,40,80,160mg/kg intraperitoneally and 20,40,80mg/kg intravenously. The changes of renal function were estimated by blood urea nitrogen(BUN)and blood creatinine and compared to histologic findings of renal tissue. From these, we concluded: 1. Intraperitoneal injection of PQ at 10, or 20mg/kg increased BUN after 5 days and it begins to decrease back toward normal range after 9 days. The increase in BUN was prompter in cases of intravenously injection. :The increase in BUN was observed soon after injection and was sustained for 5 days, after when it gradually return to normal range. However, the different route of injection. PQ at 10 or 20mg/kg hardly affect the creatinine level. But the lethal dose(40mg/kg)of PQ increased blood creatinene level immediately after injection. Because creatinine increased only when the lethal dose(40mg/kg)was injected while BUN increased both at non lethal does and lethal does of PQ, creatinine level appeared to have more prognostic value than BUN. 3. In the rabbits which survived for more than 15days from toxicity of PQ, the renal tubular necrosis is rarely observed, suggesting that the renal damage by PQ was reversible. In addition, the degree of histologic renal damage did no necessarily match with the degree of biochemical disturbances demonstrated by BUN and blood creatinine.

Salicylic Acid 투여가 흰쥐에 일으킨 염증반응에 미치는 영향

강상균,안재덕 중앙대학교 의과대학 의과학연구소 1977 中央醫大誌 Vol.2 No.1

It has been suggested that aspirin like cortisone inhibits inflammatory reaction in rats. Lysosomal membrane stability is proposed as a mechanism of antiinflammatory reaction of aspirin. This experimental study was designed to observe the effect of aspirin on inflammatory reaction of the skin in the rat. Rats are divided into 3 groups, namely control, SA Ⅰ, and SA Ⅱ. In the control group, skin incision was made then sutured on the abdominal wall after clipping of hair under anesthesia. In the SA Ⅰ group, aspirin 150㎎/㎏ was given one day before wounding. In the SA Ⅱ group, aspirin 150㎎/㎏ of aspirin was given immediately after surgical procedure. Rats are sacrificed under the scheduled time table of 6, 12 hours, 1,2,3,4,5,6,10, and 14 days after wounding, then histo-pathologic studies were carried out on the wounded skin. Obtained results were as follows: 1. SA Ⅰ and SA Ⅱ group showed obviously reduced neutrophilic leukocyte infiltration and suppressed vascular reaction in the eary stage of inflammatory process. 2. Fibroblast proliferation as well as collagen fiber formation are delayed in the repair process in the group SA Ⅰ and SA Ⅱ. 3. Inflammatory reaction and repair proces are more suppressed in the SA Ⅱ group than SA Ⅰ group. 4. The above changes suggests that anti-inflammatory reaction of aspirin is due to suppression of cell infiltration in the early stage of inflammatory reaction.

사회간접자본 민간투자사업의 핵심성공수행 요인분석에 관한 연구

강상균,김연성,유석천,이규태 한국경영공학회 2008 한국경영공학회지 Vol.13 No.2

The purpose of this study is to contribute to the development of infrastructure projects in Korea both theoretically and practically. Most importantly, critical success factors identified in this study could help private sectors succeed in carrying out infrastructure projects. The main methodology used for carrying out this study is the DHP method which is a comprehensive way of using both the Delphi technique and the AHP technique. The Delphi technique extracts critical success factors and subsequent implementation guidelines for infrastructure projects. The AHP technique was used to weigh identified factors and analyze their differences. This study will also provide private enterprises with a road map for proceeding with their projects and improving project performances. By sharing critical success factors with government authorities, infrastructure development policies and regimes could better reflect those success factors. Lastly, the study methodologies and results will serve as a theoretical base to infrastructure studies in the future. The purpose of this study is to contribute to the development of infrastructure projects in Korea both theoretically and practically. Most importantly, critical success factors identified in this study could help private sectors succeed in carrying out infrastructure projects. The main methodology used for carrying out this study is the DHP method which is a comprehensive way of using both the Delphi technique and the AHP technique. The Delphi technique extracts critical success factors and subsequent implementation guidelines for infrastructure projects. The AHP technique was used to weigh identified factors and analyze their differences. This study will also provide private enterprises with a road map for proceeding with their projects and improving project performances. By sharing critical success factors with government authorities, infrastructure development policies and regimes could better reflect those success factors. Lastly, the study methodologies and results will serve as a theoretical base to infrastructure studies in the future.

위선암에서 조직면역학적 방법을 이용한 P-glycoprotein의 분포에 관한 연구

김만성,양승하,김의한,강상균 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

P-glycoprotein, as a pleotropic membrane transport protein, shows specific localization in many normal tissue and malignant tumor. It act as an energy dependent drug pump in malignant tumors and makes difficulty for treating these tumors with anticancer drugs. Many malignant tumors such as colon carcinoma, renal cell carcinoma, hepatoma, islet cell tumor of pancreas, and adrenal cortical carcinoma, show high expression of P-glycoprotein and resistance to chemotherapy. However reports for P-glycoprotein in gastric adenocarcinoma is rare. The difference of its expression according to differentiation of gastric adenocarcinoma has been studied and its results are controversial. To observe the relationship of P-glycoprotein positivity according to differentiation of carcinoma, age and sex, adenocarcinoma 82 cases and dysplastic lesions 12 cases were analysed then processed for immunohistochemical stain by avidin-biotin complex using mAB JSB-1. The results were as followings : 1. Positive rate of P-glycoprotein in gastric adenocarcinoma and dysplastic lesions were 48.78%(40/82) and 50%(6/12). 2. Well, moderate and poorly differentiated adenocarcinoma showed positive reaction of P-glycoprotein in 51.28%(20/39), 46.43%(13/28) and 46.67%(7/15) respectively. 3. Positive reaction of P-glycoprotein in male was 53.85%(35/65) and female in 29.41%(5/7) which indicate high positive rate in male. 4. Positive rate of P-glycoprotein according to age distribution were 25%(1/4) in 20-30 decade, 42.8%(6/14) in 40 decade, 44.83%(13/29) in 50 decade, 57.14(12/21) in 60 decade and 57.14%(8/14) in 70 decade. It indicate that P-glycoprotein positivity is increased with age. The above results reveal that the expression of p-glycoprotein in gastric adenocarcinoma as related with sex and age but not with differentiation of carcinoma. These results implies that P-glycoprotein may be implicated with hormone dependent.

고유익형 KA2가 적용된 풍력 블레이드의 회전토크와 추력에 익형의 항력이 미치는 영향 분석

강상균,박성수,이상일,이장호 한국풍력에너지학회 2021 풍력에너지저널 Vol.12 No.1

Many studies have been conducted on the design of wind turbine blades and the several forces necessary for the operation of a wind turbine and its integrated load analysis such as thrust and torque generated at the design point. However, studies on the effect on such several forces by the drag force of a horizontal axis wind turbine blade have not been sufficient. The analysis of the drag effect of an airfoil on the rotational torque and thrust of wind turbine blades requires more precise design performance and drive performance of wind turbines. Therefore, it is necessary to review the degree of effect of airfoil drag force on rotational torque and thrust during the development of wind turbine blades. In this study, a wind turbine blade with the original airfoil KA2 was developed and manufactured for a performance test and the drag effect of an airfoil on the rotational torque and thrust of the horizontal axis wind turbine blade was analyzed. It was confirmed that the drag effect on torque is larger than that of thrust and that the effect of the drag force to the lift force is larger from the root to the tip.

조상설비 조합에 따른 정태적 특성 및 동태적 특성 비교

강상균,장길수,이병준,권세혁 대한전기학회 2005 전기학회논문지A Vol.54 No.4

- Various compensators are installed into the power system to operate the system economically and stably by maximizing the availability of utilities and power transmission capability. Fixed Capacitor(FC), Mechanical Switched Capacitor(MSC), and FACTS(Flexible AC Transmission Systems) are used to regulate voltage and power flow of the system. When a disturbance occurs in the power system, the Fixed Capacitor operates dependently on the voltage of the power system and cannot change the amount of installation automatically. But compared to other equipment, the Fixed Capacitor is more economical due to its low cost. Since MSC can change the amount of installation according to the state of the power system, operates more effectively than the Fixed Capacitor. FACTS have fast dynamic performance for the transient condition, but the cost is high. Therefore, it is needed to develop an optimized installation planning for the reactive power compensators by considering their dynamic performance and cost. In this paper, an optimized compensator combination and the proposed scheme is proposed and it is applied to KEPCO system in order to show its capabilities.

Stromal endometrosis

강상균 중앙대부설한국의과학연구소 1974 한국의과학 Vol.6 No.9

[ALT. VIEW]환(幻)과 현실

강상균 한국독립영화협회 2005 독립영화 Vol.25 No.-

유방암에서 Peanut lectin과 Cystol Estrogen Receptor 의 분포에 관한 비교연구

박희주,김의한,강상균 순천향대학교 1991 논문집 Vol.14 No.2

To understand interrelationship between localization of Peanut lectin and Cytosol Estrogen Recepter, the authors collected 25 cases female breast carcinoma obtained by the biopsy and mastectomy, We performed H & E stain and immunohistochemical stains by Avidin-Biotion-Complex method then analyzed their reactions. Results obtained are as following : 1. Of 25 patients with breast cancer, 15 were presented with PNA-positive cells in their tumor tissue, However, there were variation in incidence for PNA in the tumor cells depending on the degree of differentiation ; while PNA-positive cells were observed in all patients with well differentiated tumor(N=3/3), they were displayed in 50% of patients with poorly differentiated tumor(N=5/ 10). In patients with tumor with moderate differentiation. PNA-positive cells were present in 55.6%(N=5/ 9). It appears that the better the differentiation, not only the higher the incidence for PNA at the free border of cell membrance. 2. Of 25 brest cancer, 14 were presented with CER-positive cells. CER-positive cells were exhibited in 33.3%, 66.7% and 70.0% in well differentiated(N=1/ 3), moderate differentiated(N=6/9), and poorly differentiated(7/10), respectively. On view of the degree of differentiation of the tumor cells. CER-positive and PNA-positive cells reveals opposite pattern. 3. There was a some relationship between age and incidence for PNA or CER in tumor cells. In patients at age less than 40, between 40 and 50 and over 50, CER positivity in tumor cells were 13.3%, 33.3% and 53%, and PNA positivity in tumor cells were 7.1%, 36% and 57%, respectively. 4. 8 cases of PNA positivity(57.1%) was detected among 14 cases of CER positive cases, while 7 cases(63.6%) of PNA positivity was noted among 11 cases of CER negative. There the expression pattern of PNA and CER were different and unrelated each other. 5. Although stronger or more extensive staining for CER tended to be associated weaker or more restricted staining for PNA, the tendency for reciprocal correlation could not quite achieve the statistial significance.

Hashimoto씨 병의 증례보고 및 문헌적 고찰

강상균 중앙대부설한국의과학연구소 1976 한국의과학 Vol.8 No.6