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Biodegradable Stereocomplex Polylactide Having Flexible ε-Caprolactone Unit
강민규,정영미,김수현 한국고분자학회 2013 Macromolecular Research Vol.21 No.9
Stereocomplex formation between poly(L-lactide-co-ε-caprolactone) (PLLCL) and poly(D-lactide-co-ε-caprolactone) (PDLCL) is known to be disturbed when their molecular weights increase to >105 g/mol. Here, Strong and biodegradable stereocomplexes of copolymers (S-PLCL) were studied using a supercritical fluid and co-solvent system. Mechanical properties such as tensile strength were ~2.5 times increased due to high degree of stereocomplex than those of PLGA20. The addition of the flexible ε-caprolactone units to the polylactide increased its thermal stability which significantly enhanced 100% degree of stereocomplex after 2nd melt processing through DSC due to the increased mobillity of the polylactide’s chains. The degradation behavior of resulting biodegradable S-PLCL showed slow degradation with increasing CL content in 0.13 M, pH 4.3 phosphate buffers.
Analysis of Individual Case Safety Reports of Severe Cutaneous Adverse Reactions in Korea
강민규,손경희,강동윤,박한기,양민석,이주연,강혜련 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.2
Purpose: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), includingStevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemicsymptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea. Materials and Methods: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting Systemfrom 1988 to 2013. Administered drugs, demographic profiles, and causality assessment according to the World Health Organization-Uppsala Monitoring Center system were analyzed. Results: A total of 755 SCAR cases (508 SJS/TEN, 247 DRESS) were reported. The number of SCAR ICSRs has been increasingwith increasing ICSRs for overall adverse drug events. Since 2010, the number of SCAR ICSRs has increased up to 100 cases/year. Allopurinol was the most common causative drug (SJS/TEN: 10.2%; DRESS: 11.3%; SCAR ICSRs: 10.6%), followed by carbamazepine(SJS/TEN: 8.7%; DRESS: 9.7%; SCAR ICSRs: 8.6%). Regarding drug groups, antiepileptics (19.5%) and antibiotics for systemicuse (12.7%) were common causative drug groups. Twenty SCAR-related deaths were recorded. Antibacterials were the mostcommon causes of deaths (8 cases), followed by antiepileptics (5 cases). The potential risk of SCARs was not specified in the druginformation leaflet for 40.2% of drugs causing SJS/TEN and 82.5% causing DRESS syndrome in Korea. Conclusion: The number of SCAR ICSRs has increased rapidly with recent active pharmacovigilance programs in Korea. Allopurinoland antiepileptics are the most common individual and categorical causative agents, respectively.
Draft genome sequence of Streptomyces sp. P3 isolated from potato scab diseased tubers
강민규,박덕환,Kang, Min Kyu,Park, Duck Hwan The Microbiological Society of Korea 2018 미생물학회지 Vol.54 No.2
Streptomyces sp. P3 균주는 대한민국 강원도 평창의 더뎅이병 이병괴경으로부터 2017년 분리되었다. 이 논문에서는 9,851,971 bp (71.2% G + C 함량)로 구성된 P3 균주의 전체염기서열을 보고한다. 지놈은 8,548개의 코딩서열, 18개의 rRNA 그리고 66개의 tRNA 유전자를 포함하고 있다. 특히 P3 균주는 감자표면과 무종자를 이용한 병원성 검정에서 병원성을 나타내지는 않았지만, 감자 더뎅이병 유발 Streptomyces들이 보유한 병원성 유전자 중 tomA 유전자만이 존재하였다. 따라서 본 논문에 제공되는 전체염기서열은 감자 더뎅이병원세균들의 병원성 획득을 위한 진화단계에서의 이해를 높이기 위한 중요한 단서가 될 것이다. Streptomyces sp. P3 was isolated from potato scab diseased tubers in Pyeongchang, Gangwon-do, Republic of Korea in 2017. Here, we report the draft genome sequences of P3 with 9,851,971 bp size (71.2% GC content) of the chromosome. The genome comprises 8,548 CDS, 18 rRNA and 66 tRNA genes. Although strain P3 did not show pathogenicity both potato tuber assay and radish seedling assay, it possesses tomatinase (tomA) gene among conserved pathogenicity-related genes in well characterized pathogenic Streptomyces. Thus, the genome sequences determined in this study will be useful to understand for pathogenic evolution in Streptomyces species, which already adapted to potato scab pathogens.
강민규,김종학,이강욱,신영태,나기량,황평주,강정현,구영선 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.4
Acute cortical necrosis is a rare cause of the acute renal failure. It is frequently associated with complications of pregnancy. The renal biopsy is the key of diagnosis of these disease. However, the contrast enhanced CT scan can be a tool for the diagnosis of acute renal cortical necrosis, because of its noninvasiveness and constant findings(enhancement of subcapsular rim, nonenhancement of the renal cortex, enhancement of medulla, and lack of excretion of contrast media to the collecting system). This is a case of acute renal cortical necrosis diagnosed by CT scan. She had an anuria for 16 days and feature of hemolytic uremic syndrome and polycystic kidney.
Amorphous Sr0.8Bi2.2Ta2O9 Thin Films for MIM Embedded Capacitors
강민규,조광환,이칠형,윤석진,김상식,강종윤 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.41
Sr0.8Bi2.2Ta2O9 (SBT) thin films with thickness a ranging from 77 nm to 107 nm were deposited on Pt/Ti/SiO2/Si substrates by using a pulsed laser deposition method. During the deposition, the process substrate temperature was maintained at 350 ℃ for embedded capacitor applications. To form the top electrode of the MIM capacitor, we deposited Pt on the thin films by dc sputtering. The dielectric and the electrical properties of the SBT thin films were investigated in order to evaluate the performance for embedded MIM capacitors. A high capacitance density of 7.06 fF/μm2,along with a dissipation factor of 2.68%, was obtained at 1 MHz. The linear and the quadratic voltage coefficients of the capacitance were 590 ppm/V and 196 ppm/V2, respectively. These results demonstrate that the amorphous SBT thin films are good candidate materials for MIM embedded capacitor.