FCT 5 : Fractional laser-assisted topical imiquimod 5% cream treatment for recalcitrant common warts in children

( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.

수산물채취 잠수부에서 발생한 중증감압병 37예 분석

조수헌,양대현,최헌 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.1

1986년 12월부터 1988년 11월까지 2년간 지방공사 강남병원 고압산소치료센타에 내원하였던 489명의 감압병환자중 신경계증상 등 중증증상을 보인예는 39명이었다. 이중 수산물채취 잠수작업중 중증감압병에 이환되어 미해군 재가압치료표에 따라 치료가 끝난 37명에 대하여 일반적 특성 및 잠수의학적 특성에 관한 자료를 조사하였다. 중증감압병환자의 67.5%가 25∼34세 연령층에 있었으나 10.8%는 45∼49세의 고연령층 이었다. 1년 미만의 잠수경력을 가진 예가 21.6%이었으며, 잠수기술은 70%가 체계적인 교육보다는 현장에서 잠수작업을 거들면서 기술을 습득하였다. 감압병 발병당일의 잠수형태에서는 31∼50m의 수심에서 2∼8회의 반복잠수 후에 흉부통증 또는 하지감각장애 등의 증상이 나타났는데, 증상발현은 수면부상후 30분이내에 83.7 %가 그리고 3시간이내에 100% 나타났다. 증상발현후 재가압치료를 받기까지의 경과시간은 평균 18시간으로, 재가압치료를 받아 완치된 경우에 있어서는 평균 12일의 입원기간중 11.3회의 고압산소요법을 실시하였다. 중증감압병의 경과 및 회복에는 발생전날의 반복잠수와 주증상발현후 재가압 치료까지의 경과시간이 지연되는 경향을 보였다. Hospital records were reviewed for 486 divers who have been diagnosed as decompression sickness(DCS) at Kangnam General Hospital between December 1986 and November 1988. Among 39 cases classified as serious DCS(type II), the patients had been fishery diving in 97.4% of the cases. The ages of the afflicted divers ranged from 22 to 47 years, with a mean of 31.5% years. The divers were experienced being less than one year in 21.6% and 70% of them learned diving skill by self-taught. In 86.5% of the cases the divers had made multiple divies ranged in depth from 31 to 50 meters. Thirty-one(83.7%) of the patients noted their symptoms within 30 minutes of surfacing. The spinal cord was most often affected, and the most common symptoms were 'numbness' or 'tingling' in one or more extremities and discomfort or pain on the chest. Recompression treatment was delayed for 18 hours in average after the onset of dysbaric symptoms and this treatment is more likely to be effective the sooner that it commences after the onset of dysbaric symptoms.

Co-계비정질 리본의 자기특성에 미치는 열처리 효과에 관한 연구

조치현,신용진,문현욱,서강수 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

This thesis describes the effect of annealing on the magnetic properties of Co-bsaed amorphous. The basic composition of the chosen samples were Co82Si2B15 of zero magnetostriction. The sample was melted in the quartz tube with 0.5[mm∮) nozzle. and the single roll technique was used to make a amorphous ribbon, under Ar-gas pressure 0.6〔kg/cm2] and ro11 speed 28[m/sec]. The average width and thickness of sample ribbons 2.4[mm] and 45(㎛). The sample ribbons were annealed to improve the magnetic properties at temperature of 325,350,375,400 and 450℃ respectively, for 15,30,45,60 and 120 [min] at each temperature. And I have measured high per meability of 8,000∼ 13,000 through the annealed amorphous ribbons. Especially, when the amorhpous samples were annealed at 325 for 45min, the permeability of the ribbon was 13,589. Consequently. I had effects of the improvment of permeability and the average loss at the low-frequency region.

면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

1997년 포항지역에서 유행한 소아 무균성 뇌막염의 임상상

조성민,김나연,정진화,김수근,임현술 동국대학교 의학연구소 1998 東國醫學 Vol.5 No.-

1997년 포항지역에서 유행한 소아 무균성뇌막염의 임상상을 고찰하고 이 질환의 발생과 환자가 당시에 사용하던 식수와의 관계를 알아보기 위하여 1997년 5월부터 1997년 10월까지 동국대학교 의료원 포항병원소아과에 내원하여 무균성뇌막염으로 진단 받은 78명의 환아들을 대상으로 의무기록의 후향적 분석 및 식수에 관한 전화 조사를 실시하였다. 환아의 남녀비는 1.23:1이었으며 5-6세군에서 가장 많았다. 월별 분포는 5월에 시작하여 10월까지 발생하였으나 6월과 9월에 점유율이 높았다. 임상 증상 및 증후로는 발열이 가장 많았고(96.2%), 구토(89.7%), 두통(84.6%), 경부강직(73.1%), 인두 발적(71.8%), 식욕부진(52.6%) 등의 순으로 나타났다. 혈액검사 소견으로 백혈구수가 10,000/㎣ 이상으로 증가한 경우가 54.5%였고, 혈침치가 20mm/h 이상인 경우가 29.0%였으며, C반응단백이 0.5mg/dl 이상인 경우가 84.1%였다. 뇌척수액 검사소견은 백혈구수가 13-860/㎣으로 평균 241.2/㎣였고, 단백량은 평균 78.4mg/dl, 당량은 평균 70.8mg/dl였다. 합병증이나 후유증이 발생한 경우는 없었다. 발병 당시의 식수에 관한 전화 조사는 46명에서 가능하였는데 생수를 끓이지 않고 먹는 경우가 13명(28.3%), 생수를 끊여 먹는 경우가 11명(23.9%), 상수를 끓이지 않고 먹는 경우는 2명(4.3%), 상수를 끓여 먹는 경우는 20명(43.5%)으로 전체적으로 보면 물을 끓여 먹는 경우가 31명(67.4%), 물을 끓이지 않고 먹는 경우는 15명(32.6%)으로 나타났다. 본 조사에서는 무균성뇌막염이 발생하지 않은 대조군의 설정이 되지 않았고, 표본의 크기가 매우 작으며, 식수 이외의 물을 통한 전파에 관한 조사가 이루어지지 않아 본 조사 자료만으로는 무균성뇌막염의 발생과 식수와의 관계를 밝히기 어려웠다. 이를 밝히기 위해서는 지역 주민을 대상으로 한 역학조사와 무균성뇌막염이 유행할 당시에 식수 및 식수 이외에 사용하는 물에 대한 역학 조사 및 바이러스 검사 등이 필요할 것으로 생각한다. This study was performed to evaluate the clinical features of aseptic meningitis in Pohang City in 1997 and its relationship to drinking water. We reviewed the clinical records of 78 aseptic meningitis patients who had been admitted to Dongguk University Pohang Hospital, and investigated the drinking water of patients by telephone survey. The results were as follows: 1) The ratio of male to female was 1.23:1. 2) The aseptic meningitis occurred in children of all age groups, but was most prevalent in 5-6year old children. 3) All the cases developed from May to October, but they showed two peaks in June and September. 4) Fever was the most common clinical manifestation(96.2%), followed by vomiting(89.7%), headache(84.6%), neck rigidity(73.1%), pharyngeal injection(71.8%), and anorexia(52.6%). 5) On admission leukocytosis(WBC > 10,000/㎣) on peripheral blood was showed in 64.5%, and increased erythrocyte sedimentation rate(≥ 20 mm/h) in 29.0%, and increased C-reactive protein(≥ 0.5 mg/dl) in 84.1%. 6) On CSF examination, leukocyte count was in the range of 13 to 860/㎣ (mean 241.2/㎣), protein in the range of 0 to 253 mg/dl(mean 78.4 mg/dl), and glucose in the range of 35 to 115 mg/dl(mean 70.8 mg/dl). 7) There was no case who developed any complication. 8) On the telephone survey about the drinking water, we were able to do the survey in 46 cases, raw underground water was used in 13 cases(23.8%), boiled underground water in 11 cases(23.9%), raw tap water in 2 cases(4.3%), and boiled tap water in 20 cases(43.5%). We could not identify the close relationship between the drinking water and aseptic meningitis because of the small sample size, the absence of control group, and the difficulties in the study of past event. Epidemiologic and virologic studies of drinking water will be necessary.

한국 재래 우 및 산양 위장관의 somatostatin cell에 대한 면역조직화학적 분포

조성환,김현수,박배근,윤원기,손화영 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

The relative frequency and distribution of somatoatatin immunoreactive cells were investigated by the immunohistochemical method in the gastrointestinal tract of the Korean native cattle and goat. The results obtained were as follows: In the Korean native cattle, somatoststin cells were a few in the pyloric and duodenal region and rarely seen in fundic region, jejunum, ileum, cecum, proximal colon, central coil, distal colon and rectum. In the Korean native goat, somatostatin cells were the most numerous in the pyloric region and the next in the fundic region. And they were a few in the duodenum, not detected in the cecum and sparse in the jejunum, ileum, proximal colon, central coil, distal colon and rectum.

21세기를 향한 국가기술자격제도의 발전방안 연구 : New Directions Towards the 21st Century

조정윤,박종성,김현수 한국산업교육학회 1999 산업교육연구 Vol.6 No.-

21세기를 대비한 국가기술자격제도의 발전 방안을 국가 경쟁력 확보 측면에서 모색하기 위해 이 연구에서는 국제 경제 환경 변화에 따른 주요국의 자책제도 대응 방향을 살펴봄으로써 우리나라 국가기술자격제도에 반영해야 할 시사점을 도출하였다. 이와 함께 국가기술자격제도의 운영 실태를 파악하고 자격제도에 관한 요구를 파악하기 위해서 39개 기관을 방문하여 넓은 의미의 국가기술자격 관리자들을 대상으로 면담조사를 수행하였고, 기 국가기술자격 취득자 480명을 대상으로 설문조사를 실시하여 의견을 수렴하였다. 이상의 연구를 통해 21세기를 향한 국가기술자격제도의 발전 방향을 기술·기능 분야의 합리화 방안, 서비스 분야의 합리화 방안, 자격 취득자의 사회적 우대 방안, 자격 정보체제구축 방안, 기초직업능력과의 연계 방안, 민간자격으로 관리·운영의 전환 방안, 국제적 통용성 확보 방안, 통합 국가자격체제 구축 방안으로 나누어서 제시하였다. There are strong links between a nation's economic prosperity, its international competitiveness, and the competency of its population. As international competition intensifies and the rate of economic and technological change accelerates, advanced countries increasingly strive to improve their competitiveness by reforming their national qualification systems. With the advent of the information age and the knowledge- based society, human resource development has become a key factor in determining a nation's competitiveness. And technological qualificatior systems have a direct and significant influence on human resource development. In order to guarantee Korea's continued development as a competitive member of the international community, it is demanded that a Korean Technology Qualification System(KTQS) be established to set Ae nation's future course for the 21st century. Extensive and concrete development plans for KTQS in 21st centry are as follows: First of all, it is essential tc prepare policies for improving the effectiveness and suitability of KTQS and its operations as they apply to the domains of technology and craft. Second, in terms of the service fields, policy measures should be taken to improve and guarantee the diversity of qualification items. Third, appropriate policy measures should be taken in order to raise the general social status of NTQ holders. Fourth, policies should be introduced which will allow for the enhancement of generic competency under the qualification system. Fifth, appropriate policies should be prepared to facilitate a partial transition from a state-run qualification system to a private system. Sixth, with the recent development of international agreements on profession qualifications, it is important to guarantee that Korean qualifications have a common, international currency. Finally, it is imperative that policies be prepared which can establish the necessary foundations for the unification of national qualifications under a single NQ.

도시체계의 형성과정

조현수 평택대학교 1996 論文集 Vol.8 No.-

슈만의 피아노작품「크라이스레리아나, op.16」과 E.T.A.호프만의 소설「카터 무어」에 나타난 구조적 연관성

조현수 명지대학교 예체능연구소 1999 藝體能論集 Vol.10 No.-

The Relationship between literature and music implied in R.Schumann's Kreisleriana provides performers with specific clues to understanding the content of the music. It is thought that E.T.A. Hoffmann's novel, Kater Murr might have influenced Schumann when he wrote Kreisleriana. They share the similar structure and character. The purpose of this paper is to compare Kreisleriana with Kater Murr in order (1) to understand how the music is structured as a unified cycle even though it is often fragmentary, and includes abrupt contrasts, and (2) to discover how Schumann associated particular compositional techniques with different kinds of emotional expression or character portrayal.

Dehydroepiandrosterone과 노화

조수현 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

There is an increasing evidence that dehydroepiandrosterone(DHEA) is an important mammalian steroid. Cancers. artherosclerosis, and dectease of immunloogical responses and brain function are frequently observed in aging. These changes in aging is accompanied by a progressive decline in the sectetion of the adrenal DHEA, the steroids at the highest concentration in the blood of young man. Until recently, no specific molecular or cellular target of DHEA has been described. However, the mode of action of DHEAprobably involved two series of mechanisms : 1) transformation of DHEA into active sex steroids(andregen, esterogen) that promote overall anabolic effects in several tissue, and 2) effects in the central nervous system through an inhibition of the GABAA receptor and a potentiator of NMDA and sigma receptor function. In the last few years, striking effects of DHEA has been obtained mostly in animal experiments. The preventive and/ or therapeutic activity of DHEA has been reported for the development of arte-rial lision, diabetes, cancer, infection and improvement of physical and psychological well-being. A steroid without(up to now)a proper selective receptor, and acting in part through metabolites, DHEA is not a typical hormone. At present there is only the intention of relieving, for as long as ossible, some of damage caused by aging within the framework of research based on physionlogical data and under medical surveillance. Several years will be necesary to pass from precise and limited observations to al sure, dfficacious DHEA useable by many people.