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Seo, Ho-Jun,Jung, Young-Eun,Woo, Young Sup,Jun, Tae-Youn,Chae, Jeong-Ho,Bahk, Won-Myong John Wiley Sons, Ltd. 2009 Human psychopharmacology Vol.24 No.2
<B>Objective</B><P>The extent of weight changes in depressed patients who use atypical antipsychotics (AAP) as augmentation could not be easily predicted due to weight related symptoms of depression and the interaction with antidepressants which have weight reducing effects.</P><B>Methods</B><P>Patients were treated with either antidepressants augmented with AAP for more than 2 weeks (AAP group, n = 100) or only with antidepressants (non-AAP group, n = 172) during the admission between 2002 and 2006, and the differences in weight were analyzed.</P><B>Results</B><P>Mean weight gains of AAP group were significantly higher than those of non-AAP group (2.98 ± 1.87 kg vs. 1.70 ± 1.85 kg, p = 0.001). When stratified by antidepressants, the significant difference between the two groups was shown among the subjects who had taken serotonin reuptake inhibitors (SSRIs), but not mirtazapine and venlafaxine (3.42 ± 2.01 kg vs. 1.48 ± 1.79 kg, p < 0.001). Comparing among different combinations in AAP group showed that subjects treated with SSRIs and olanzapine had the greatest weight gain (4.21 ± 1.90 kg), significantly higher than that of the other subgroups (p < 0.001).</P><B>Conclusions</B><P>Our findings suggest that AAP used in patients with depression could severely aggravate preexisting weight-related problems of antidepressants use and the possibility that the combined use with specific antidepressants could have a unique effect on weight by drug–drug interactions. Copyright © 2009 John Wiley & Sons, Ltd.</P>
Soil conditions during cultivation affect the total phenolic and flavonoid content of rosemary
Seo Ji Won,Kim Soo Kyung,Yoo Ji Hye,Kim Myong Jo,Seong Eun Soo 한국응용생명화학회 2022 Journal of Applied Biological Chemistry (J. Appl. Vol.65 No.2
In this study, the effects of soil conditions on antioxidant activities of the aerial and underground parts of rosemary were assessed to determine the most effective soil conditions for cultivation. The antioxidant activity was the highest (51.58±2.93 μg/mL) when cultivated in the mixture of gardening soil and vermiculite using DPPH assay. The antioxidant activity of underground parts the highest (127.48±12.38 μg/mL) when cultivated in the mixture of soil, vermiculite, and perlite. ABTS assay showed that the antioxidant activity of aerial parts was 230.34±57.93 μg·mL−1 when cultivated in the mixture of gardening soil and vermiculite and that of underground parts was 320.98±16.04 μg·mL−1 when cultivated in the mixture of gardening soil, vermiculite, and perlite. The total phenolic content of aerial parts was the highest (155.25±2.96 mg GAE/g) when cultivated in the mixture of gardening soil. The total flavonoid content of aerial parts was the highest (67.32±5.27 mg QE/g) when cultivated in the mixture of gardening soil. Therefore, the mixture of gardening soil, vermiculite, and perlite is superior to gardening soil alone for cultivation of rosemary to increase its antioxidant activity as well as total phenolic and flavonoid content.
Seo Mansuk,Choi Won-Seo,Woo Young Sup,Bahk Won-Myong 대한우울조울병학회 2024 우울조울병 Vol.22 No.1
Background: Metformin (MET) has been used to prevent weight gain in patients treated with antipsychotic drugs. However, liraglutide (LIRA), initially used for diabetes, is now considered for obesity treatment. The aim of this study was to investigate the effectiveness and safety of these drugs in patients with psychiatric disorders. Methods: A retrospective chart review was performed on patients prescribed and administered MET and LIRA from January 1, 2017 to August 31, 2023. To assess treatment efficacy, the mean change in the body mass index of the patients before and after drug use was calculated for both medications. Drug safety was evaluated by determining the early discontinuation and occurrence of adverse effects. Results: We collected data from 45 patients, with the majority being women (84.4%). The most frequently diagnosed psychiatric disorders were depressive disorder for LIRA (35.3%) and psychotic disorder for MET (63.6%). No demographic variations were observed between patients who were administered the two types of drugs. The treatment efficacy and safety of both drugs did not show any statistically significant difference. When conducting a subgroup analysis exclusively on patients diagnosed with psychotic disorders (n = 14), MET showed better efficacy; however, no statistically significant difference was observed (−2.48±3.17 vs. 0.56±2.93, t=−1.860, p=0.088). Conclusion: LIRA and MET did not show any significant differences in terms of therapeutic efficacy and safety. However, in patients diagnosed with psychotic disorders, MET showed better efficacy and was cost-effective than LIRA. Future studies with larger sample sizes are required to confirm these findings.
Sang Ik Han,Suk Bok Bae,Tae Joung Ha,Myong Hee Lee,Ki Chang Jang,Woo Duck Seo,Geum Yong Park,Hang Won Kang 한국육종학회 2011 한국육종학회지 Vol.43 No.2
The groundnut or cultivated peanut (Arachis hypogaea L.) in Korea consists of 36 domestic varieties which have been developed and registered as cultivars for the public during last 25 years. To screen and identify of Korean peanut varieties and genetic resources, we present a simple and reliable method. A methodology based on simple sequence repeat (SSR) markers developed and widely used for prominent gene identification and variety discrimination. For identification of those 36 Korean peanut varieties, 238 unique peanut SSR markers were selected from some previously reported results, synthesized and used for polymerase chain reaction (PCR). Data were taken through acryl amide gel electrophoresis and changed into proper formats for application of data mining analysis using Biomine (all-in-one functional genomics data mining program). Consequently, twelve SSR primers were investigated and revealed the differences between those 36 varieties. These primer pairs amplified 27 alleles with an average of 2.3 allele per primer pair. In addition, those results showed genetic relationship by classification method within 36 varieties. The approach described here could be applied to monitoring of our varieties and adapting to peanut breeding program.
Sohn, Myong Hwan,Lim, Seungmin,Seo, Kyung Won,Lee, Sang Joon Oxford University Press 2013 Journal of plankton research Vol.35 No.6
<P>The effect of ambient medium viscosity on the motility and flagellar beating motion of the dinoflagellate <I>Prorocentrum minimum</I> was experimentally investigated. <I>Prorocentrum minimum</I> is a thecate desmokont dinoflagellate with two flagella that emerge from the flagellar pore at the anterior end of the cell. A digital holographic particle tracking velocimetry technique was employed to capture the swimming trajectories of hundreds of <I>P. minimum</I> cells and to extract the kinematic motion parameters. The viscosity of the surrounding medium was changed from 1.12 cP (natural sea water at 22°C) to 11.31 cP by adding methylcellulose to increase fluid viscosity. In natural sea water, the swimming speeds of <I>P. minimum</I> cells (<I>n</I> = 77) in a helical motion ranged from 5.4 to 138.4 µm/s with a mean speed of 51.3 ± 27.9 µm/s. The helix radius and pitch of the swimming trajectories are 3.08 ± 0.64 and 25.34 ± 7.96 µm/s, respectively. The longitudinal flagellum beats with a planar wave at a beating frequency of 87.10 ± 10.96 Hz. On the other hand, the transverse flagellum beats with a helical wave at a beating frequency of 45.38 ± 13.61 Hz. As the ambient medium viscosity increases, the beating frequency of flagella decreased and consequently, the swimming speed of <I>P. minimum</I> was reduced.</P>
대도시 스포츠 센터의 문화적 특성과 조직 효율성의 관계
서명원(Seo Myong-Won) 한국체육과학회 2001 한국체육과학회지 Vol.10 No.1
The purpose of this study was to verify the relationship between cultural characteristics and organizational effectiveness of the commercial sport organizations. More specially, this study aimed: (1) to analyze the effects of the socio-demographic variables on the cultural characteristics of the sport organizations, (2) to analyze the relative effects of the cultural characteristics on the organizational effectiveness. In order to achieve the purposes, the data were collected from 362 male/female employees who worked at the commercial sport organizations which were located in Seoul City. The statistical methods used for the analysis of this study were multiple classification analysis, n-way analysis of variance, and multiple regression analysis. The conclusions of this study were as follows: First, there were statistically significant differences between socio-demographic variables of the employees and cultural characteristics of the sport organization. That is, female, senior high school graduates, twenty years to twenty-five years old, one to three year job career, and fifteen million won to twenty million won salary variables were the effective variables on the cultural characteristics of the sport organization. Second, the scholastic career and the job career were the influential variables on the job satisfaction of the employees. Third, the employee-centered leadership behavior was the effective variable on the cultural characteristics of the sport organization. Fourth, the role culture, the human culture, and the power culture were the influential variables on the job satisfaction of the employees.
증례 : 신부전과 빈혈로 발현된 이소성 부갑상선암 1예
강명수 ( Myong Su Kang ),이호연 ( Ho Yun Lee ),서평주 ( Pyong Ju Seo ),김희진 ( Hee Jin Kim ),윤성철 ( Sung Chul Yun ),서필원 ( Phil Won Seo ),권미선 ( Mi Seon Kwon ) 대한내과학회 2006 대한내과학회지 Vol.71 No.4
저자들은 일차성 부갑상선기능항진증으로 인한 고칼슘혈증, 급성신부전, 대사성 골질환 및 심한 빈혈을 보인 환자에서 이소성 종격동 부갑상선암을 절제한 후 고칼슘혈증 뿐 아니라 골수섬유증에 의한 빈혈과 급성신부전도 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Parathyroid carcinoma is an uncommon cause of PTH-related hypercalcemia with a reported incidence of 0.4% to 5% of all cases of primary hyperparathyroidism. Even though the clinical manifestations of hyperparathyroidism are more severe in patients with parathyroid carcinoma than in those with parathyroid adenoma, it is difficult to differentiate carcinoma from adenoma preoperatively. Parathyroid carcinomas are usually larger and firmer than parathyroid adenomas and patients with parathyroid carcinoma have a higher incidence of renal dysfunction, bone disease and gastrointestinal symptoms. Anemia is an uncommon clinical feature of parathyroid carcinoma. There have been no prior cases of ectopic parathyroid carcinomas reported to date. In this article, we report the case of a 26-year-old man who developed severe anemia and acute renal failure due to an ectopic parathyroid tumor and was diagnosed with parathyroid carcinoma postoperatively. His serum calcium levels returned to normal and the anemia resolved postoperatively.(Korean J Med 71:435-441, 2006)