생체용 Ti합금의 양극분극특성에 미치는 Zr 및 Pd의 영향

정종현,이길홍,최칠남,노학,백승남,이상열 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.2

The corrosion resistance of Ti-Zr-Pd-Cr alloys were investigated in order to reveal their possible use for new biomedical implant materials. Titanium alloys consisting of 10∼20%Zr, 0.0∼0.4%Pd and 0.15%Cr were prepared by vacuum arc-melting as alloying elements instead of using hardness Al and V in response to recent concerns about the long term safety of Ti-6%Al-4%V ELI alloys. The Ti-Zr-Pd-Cr alloys were heat-treated at 1000℃ for 2hrs under a vacuum atmosphere. The effect of Zr and Pd Ti alloys on the corrosion resistance for biomedical implant was investigating the anodic polarization curve at 37℃ in 5%HCI solution deaerated by high-purity N₂gas bubbling. The critical current density for passivation(I ) of Ti-Zr-Pd-Cr alloys didn't reveal markedly. Passive current density(I ) at 1.0V vs. SCE of this alloys decreased with increasing Zr in the contents from 10 to 20% and decreased with containing Pd in the range from 0.2 to 0.4%. Potential(E ) at 0.1A * m-² of this alloys increased with increasing Zr in the contents from 10 to 20% and increased with containing Pd in the range from 0.2 to 0.4%. For the Co-30%Cr-6%Mo alloy, passivity zone is narrow, and rapid increase of current density result from the low potential in comparison with Ti and Ti alloys. The corrosion resistance by the anodic polarization of Ti-20%Zr-0.2%Pd-0.15%Cr alloy was found to be superior to those of the Ti, Ti-6%Al-4%V alloy and Co-30%Cr-6%Mo alloy. The passive films formed on the Ti-20%Zr-0.2%Pd-0.15%Cr and Ti-6%Al-4%V alloys in the anodic polarization test consist mainly of TiO₂, Ti compound, ZrO₂, Al₂O₃and V₂O₃.

주요우울증에 대한 벤라팍신의 효과 및 안전성

이민수,남종원,강성민,연병길,오병훈,이철,정인과,채정민,백인호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 주요우울증 환자에서 벤라팍신의 치료 효과와 안정성을 조사하기 위해 다기관 개방연구를 시행하였다. 방 법 : DSM-IV 진단 기준에 의거하여 주요우울증으로 진단된 환자중 벤라팍신 투여에 동의한 환자를 대상으로 하였다. 선택된 환자에서 다른 항우울제를 복용하고 있는 경우 14일 이상의 약물 배설기간을 가진후 벤라팍신을 6주간 투여하였으며, 기준점, 1주, 2주, 4주, 6주 후에 HAM-D, MADRS, 그리고 CGI등을 사용하여 평가하였다. 본 연구기간중 발생된 모든 부작용은 부작용의 발생 및 소설 시기, 심한 정도, 발생 빈도, 벤라팍신과의 관련성, 관련 조치 및 결과에 대하여 증례기록서에 기록하도록 하였다. 결 과 : 총 141명을 대상으로 하였으며, 이중 94명(66.7%)이 6주간의 연구를 완결하였고, 47명(33.3%)이 중도탈락하였다. HAM-D총점수는 벤라팍신 투여 1주후부터 유의한 감소를 나타내었으며, 2주,4주, 6주후에도 지속적인 감소를 보였다. MADRS의 총점수도벤라팍신 투여 1주 후부터 유의한 호전을 나타내었으며, 2주, 4주, 6주 후에도 지속적인 감소를 보였다. CGI에서도 기준점, 1주, 2주, 4주, 6주 후 각각의 시점 사이에 유의한 호전이 보였다. 활력징후, 일반 혈액학, 생화학, 심전도 검사 등에서 유의한 변화는 없었다. 벤라팍신과 관련된 부작용으로 흔히 보고한 증상은 오심(10.6%), 소화불량(9.5%), 변비(8.5%), 현기증(8.5%)등 이었다. 결 론 : 다기관 개방연구를 통해 주요우울증 환자에 대한 벤라팍신의 투여는 우울증상의 호전에 효과적이었으며 안전하였다. Objective : A Multicenter open-label study was conducted to evaluate the clinical efficacy and safety of venlafaxine for the tretment in patients with major depression. Method : The study was done in patients with major depression diagnosed by DSM-IV who accepted venlafaxine medication. In cases of the patients taking other antidepressants, 6 weeks of venlafaxine medication was carried out after 14 days of drug excretion period and evaluation using HAM-D, MADRS, and CGI was done at baseline, and after 1, 2, 4, and 6 weeks. Regarding all side effects that had occurred during the period of our study such as their developed/disappeared time, severities, incidences, relationship with venlafaxine, managements and results have been putted into the records. Results : A total of 141 patients were enrolled. Among 94 of them finished the 6 weeks of research and 41 of them did not make it through the research. Total HAM-D scores showed significant decrease after 1 week of venlafzxine medication and continous decrease through the study period. Total scores of MADRS also showed significant improvement after 1 week and continuous decrease through the study period. Similarly, CGI showed significant improvement between baseline, 1, 2, 4, and 6 weeks. There were no significant changes in vital sign, CBC, chemistry, and EKG. The commonly reported side effects of venlafaxine were nausea(10.6%), indigestion(9.5%), constipation(8.5%), and dizziness(8.5%). Conclusion : According to the results, venlafaxine was effective and safe in the treatment of patients with major depression.

Head-Space SPME에 의한 생체시료 중 메스암페타민류 분석(Ⅲ)

박미정,최상길,손행자,최화경,최영남,허상철,박종서,정희선 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

현행 고등학교 화학 교과서 비교 연구

오제직,최석남,이종길 공주대학교 사범대학 과학교육연구소 1994 과학교육연구 Vol.25 No.1

This paper aims to help the teachers select the textbook and provide them with the basic teaching materials as an ideal model by analyzing the organization (its element and appropriateness), volume amount, experiment matter, and the contents of the highschool chemistry textbooks, which have been revised in accordance with the 5th amended curriculum. The results of the analogy are as follow 1. Organization (its element and appropriateness) : Though having some distincitive characteristics, all the textbooks have almost the same introduction, development, summary, and further study, which are appropriate for the textbook model. 2. The volume amount: All the textbooks have almost the same frame, but s a big difference in such things as the number of pages, of pictures and charts, of Gothic terminology, and relative importance of each chapter. And all the materials such as pictures and photos are black-and-white, which we think are less helpful to the students` study. 3. The experiment matter: There`s a geat difference in the number, kinds, ratio contents and subject of experiment in each chapter. And there are some distinctive characteristics in the type, level, method, and investigative skills of the experiments. 4. The contents : There are considerable differences in the additional and reduced sections. Therefore, which book is selected is very important, and the teachers should not skip any class-work.

대황황련해독탕의 사염화탄소 유발 간장해 보호효과 미치 급성독성

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-

ABSTRACT - This study was performed to evaluate hepatoprotective effect of daewhang-whangryunhaedok-Tang(DWT) on liver injured rats induced by CCI_4 and the acute oral toxicity of it in mice. The activities of serum transaminase(ALT/AST), alkaline phosphatase(ALP) and lactic dehydrogenase(LDH), the levels of serum total cholesterol(TC) and triglyceride(TG), change of liver enlargement, and inhibitory activities of lipid perotidation, catalase and glutathione-S-transfrease(GST) in liver microsome were determined in hepatotoxic rats induced by CCI_4. DWT was significantly reduced the serum ALT, AST, ALP, LDH. TC and TG lecels. And, the increase of lipid peroxidation, decrease of catalase and GST activities in the liver microsome of CCI_4-intoxicated rat were significantly improved by the treatment of DWT. Male and female mice were administered maximum dosages of 5.000 mg/kg b.w. of DWT. After single oral administration of DWT to mice, we observed them daily for 2 weeks.DWT did not induce any toxic signs in the mortalitie, clinical signs, body weight changes, and gross necropsy finfings of mice. Based in these results. It is concluded that DWT may have the hepatoprotective effect on CCI_4 induced hepatotoxicity in rats. Also. DWT may have no side effect and its LD_50 value may be over 5.000mg/kg b.w. in mice.

대황황련해독탕의 항고지혈증 작용

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.

Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer

Jong Kil Nam,Dong Hoon Lee,Sung Woo Park,Sung Chul Kam,Ki Soo Lee,Tae Hyo Kim,Taek Sang Kim,Cheol Kyu Oh,Hyun Jun Park,Tae Nam Kim 대한남성과학회 2017 The World Journal of Men's Health Vol.35 No.1

Purpose: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival. Materials and Methods: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate. Results: Clinicopathologic and outcome information was available for 52 male patients (mean age, 64.3 years; mean follow-up, 61.4 months). At presentation, 17 patients were node-positive, and 4 had metastatic disease. Management was partial penectomy in 34 patients, total penectomy in 12 patients, and chemotherapy or radiotherapy in 6 patients. The pathology reports were squamous cell carcinoma in 50 patients and other types of carcinoma in the remaining 2 patients. Kaplan-Meier survival analysis showed a 5-year CSS rate of 84.0%. In univariate and multivariate analyses, the American Joint Committee on Cancer (AJCC) stage and pathologic grade were associated with survival. Conclusions: Partial penectomy was the most common treatment of penile lesions. The oncologic outcomes were good, with a 5-year CSS of 84.0%. The AJCC stage and pathologic grade were independent prognostic factors for survival.

Torsion of an Indirect Hernia Sac Causing Acute Scrotal Swelling in a Child

Nam, Jong Kil,Ahn, Jae Hyun,Kim, Hyeon Woo,Park, Hyun Jun,Lee, Sang Don,Chung, Moon Kee Korean Society for Sexual Medicine and Andrology 2012 The World Journal of Men's Health Vol.30 No.2

<P>Torsion of a hernia sac is an extremely rare condition that presents as acute scrotum in children. We report a case of a 6-year-old boy who presented with an acute scrotum and was found during surgical exploration to have torsion of an indirect hernia sac associated with hydrocele. Upon scrotal exploration, deterioration of the scrotum due to inflammatory changes was found. A necrotic cyst was recognized within a communicating hydrocele of the scrotum and was twisted at an angle of about 360°. All urologists should be aware of this special condition in the differential diagnosis of acute scrotum.</P>

Predicting Progression and Survival in Korean Patients with High Grade T1 Bladder Cancer Using EORTC Risk Tables

Jong Kil Nam,Dong Hoon Lee,Tae Nam Kim,Sung Woo Park,Moon Kee Chung 대한비뇨기종양학회 2015 대한비뇨기종양학회지 Vol.13 No.3

The treatment of high grade T1 bladder cancer remains controversial because of the particularly high risk of recurrence and progression. The purpose of this study was to compare the oncological outcomes of radical cystectomy and a bladder preservation approach using European Organization for Research and Treatment of Cancer (EORTC) risk tables. Among 688 transurethral resections of bladder tumors for patients with non-muscle invasive bladder cancer conducted between 2000 and 2010, 102 patients who had a history of high grade T1 were included. All patients were treated by transurethral resection with additional intravesical Bacillus Calmette-Guerin and 33 patients were treated with deferred radical cystectomy. The risk classifications for tumor recurrence, and progression and survival rates were calculated using the EORTC risk tables. At a follow-up between 48 and 164 months (mean 90.1 months), 53 patients recurred, 34 patients progressed, and 18 patients died. In high grade T1 patients, the probability of progression was 15% in patients in the high risk group and 57% in patients with highest risk at 5 years. The bladder cancer specific survival was 95% in high risk patients and 88% in patients at highest risk at 5 years. High grade T1 bladder cancers are heterogeneous in nature, which complicates treatment decisions. Patients in the highest risk group in EORTC risk tables have different feasible treatment options including early cystectomy.

Usefulness of Cystography after Radical Retropubic Prostatectomy

Jong Kil Nam,Chang Soo Park,Tae Nam Kim,Sung Woo Park,Wan Lee,Moon Kee Chung 대한비뇨기종양학회 2011 대한비뇨기종양학회지 Vol.9 No.1

Purpose: To evaluate the usefulness of cystography after radical retropubic prostatectomy and the appropriated period of indwelling catheter removal, we prospectively compared the usefulness of cystography and pericatheter RGU to assess the integrity of the anastomosis site. Materials and Methods: Between 2009 and 2010, cystography and pericatheter RGU was performed in 113 patients who underwent radical prostatectomy on POD 3 and 7 to reveal the presence of extravasation. If anastomotic extravasation was showed by both tests on POD 7, we performed the follow-up imaging study until there was no sign of the contrast extravasation. Results: The mean age of the study population was 66.0±6.1 years (range 51-82). The number of the patients who showed no extravasation on POD 3 and 7 were 81 and 96 patients, respectively. In cases of extravasation on POD 3, 2 patients showed only on cystography, 3 patients only on pericatheter RGU and 27 patients on both images. In cases of extravasation on POD 7, 3 patients showed only on cystography, 2 patients only on pericatheter RGU and 12 patients on both images. The 244 pairs of total 259 pairs (94.2%) showed concordant results on both imaging studies. There was no significant difference in extravasation rates between the two operation methods Conclusions: Our study showed that both tests provided similar results in all patients. However, because cystography is more simplicity, and less affected by technique, we suggest that cystography is more preferable. Because of the false negative results and the potential for disruption, we currently recommend delaying catheter removal until postoperative day 7 or later.