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Cho, EunAe,Kwon, HyukSang,Bernard, Frederic 한국부식방식학회 2003 Corrosion Science and Technology Vol.2 No.4
The electronic properties of the passive film formed on Fe-20Cr ferritic stainless steel in pH 8.5 buffer solution containing 0.05 M EDTA (ethylene diammine tetraacetic acid) were examined by the photocurrent measurements and Mott-Schottky analysis for the film. XPS depth profile for the film demonstrated that Cr content in the outermost layer of the passive film was higher in the solution with EDTA than that in the solution without EDTA, due to selective dissolution of Fe by EDTA. In the solution with EDTA, the passive film showed characteristics of an amorphous or highly disordered n-type semiconductor. The band gap energies of the passive film are estimated to be ∼ 3.0 eV, irrespective of film formation potential from 0 to 700 mV_(SCE) and of presence of EDTA. However, the donor density of the passive film formed in the solution with EDTA is much higher than that formed in the solution without EDTA, due to an increase in oxygen vacancy resulted ti-om the dissolution of Fe-oxide in the outermost layer of the passive film. These results support the proposed model that the passive film formed on Fe-20Cr in pH 8.5 buffer solution mainly consists of Cr-substituted γ-Fe₂0₃.
Cho, Eunae,Choi, Jae Min,Kim, Hwanhee,Tahir, Muhammad Nazir,Choi, Youngjin,Jung, Seunho Rapid Communications of Oxford ; Kluwer Academic P 2013 Biometals Vol.26 No.2
<P>Iron is an essential nutrient for nitrogen-fixing legume root nodules, and the chelation of ferrous iron plays an important role in the mobility and availability of iron to the legume. In the present study, we investigated the iron-binding properties of low-molecular weight succinoglycans isolated from the nitrogen-fixing bacterium, Sinorhizobium meliloti. The low-molecular weight succinoglycans comprising three monomers (M1-M3), four dimers (D1-D4), and six trimers (T1-T6) of the succinoglycan repeating unit were purified by various chromatographic techniques. Interestingly, the colorimetric ferrozine method showed that the succinoglycans T6, M3, and D3 demonstrated a ferrous iron chelating ability of 83, 63, and 38 % per mg, respectively. The individual binding constants were determined as 43703, 2313, and 760 M(-1) for succinoglycans T6, M3, and D3 using ultraviolet-visible spectroscopy. The complexation of succinoglycan and ferrous iron can cause structural changes, which were analyzed by circular dichroism spectroscopy. Furthermore, the complex could provide antioxidant activity through an anti-Fenton reaction. These results demonstrate that the low-molecular weight succinoglycans can effectively modulate iron biochemistry as a novel ferrous iron-acquisition system of S. meliloti.</P>
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus
Cho, Euna,Ryu, Eun Jin,Jiang, Fen,Jeon, Ung Bae,Cho, Mong,Kim, Cy Hyun,Kim, Miyoung,Kim, Nam Deuk,Hwang, Tae-Ho Dove Medical Press 2018 Drug design, development and therapy Vol.12 No.-
<P><B>Purpose</B></P><P>Oncolytic poxvirus has shown promise in treating various solid tumors, such as liver cancer, and administration of oncolytic poxvirus via the hepatic artery may provide more survival benefits than other routes of administration. However, there is a lack of safety information to guide the application of hepatic arterial infusion (HAI) of oncolytic poxvirus in human studies. To investigate the acute and chronic toxicity of HAI administration of oncolytic poxvirus in animals and provide safety information for future human studies.</P><P><B>Methods</B></P><P>VV<SUP>tk−</SUP>, a vaccinia poxvirus with inactivated <I>thymidine kinase</I> gene, was administered via HAI to rabbits with normal liver function under angiography (1×10<SUP>8</SUP> or 1×10<SUP>9</SUP> pfu), and rats with N-nitrosomorpholine-induced precancerous liver cirrhosis under open surgery (1×10<SUP>8</SUP> pfu). Body weights and survival were monitored and blood samples were collected for hematological and biochemical tests. Distribution of A56 (a specific marker for poxvirus infection) in rabbit organs was evaluated using immunofluorescence assays.</P><P><B>Results</B></P><P>HAI of high doses of VV<SUP>tk−</SUP> did not cause any acute or chronic changes in body weight, survival or in biochemical, hematological tests in the 2 animal models, and none of the changes showed dose dependency (in rabbit study), or were influenced by liver cirrhosis (in rat study). A56 was not detected in any of the major rabbit organs.</P><P><B>Conclusion</B></P><P>HAI may provide a safe alternative route of oncolytic poxvirus administration for human studies.</P>
Cho, Eunae,Hu, Yiluo,Choi, Youngjin,Jung, Seunho Elsevier 2018 Journal of industrial and engineering chemistry Vol.63 No.-
<P><B>Abstract</B></P> <P>We have reported a hybrid polymer composite, consisting of a supramolecular assembly of polydiacetylene (PDA) and phospholipid, that undergoes chromatic and fluorogenic changes after specific interactions with progesterone, the pregnancy hormone. Progesterone was selectively detected among 10 steroids by the mixed polymer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and PDA at an optimized ratio of 1:9. The triggering effect of progesterone on the membrane mimetic system were investigated using UV–vis, fluorescence, circular dichroism spectroscopy, Raman scattering, dynamic light scattering, transmission electron microscopy, and computational method. These results offer insight into self-assembly disruption and membrane targeting antibiotics as well as PDA-based sensing technology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A DMPC/PDA biomimetic assembly is reported as a colorimetric and fluorescent sensory platform for progesterone. </LI> <LI> Progesterone was detected exclusively among 10 different steroid compounds using the biomimetic membrane interface. </LI> <LI> The triggering effect of progesterone on DMPC/PDA membrane mimetic system was evaluated using various analytical tools. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Poster Session : PS 1003 ; Lactulose Breath Test as Prognostic Factor in Irritable Bowel Syndrome
( Eunae Cho ),( Jong Sun Rew ),( Hyun Soo Kim ),( Chang Hwan Park ),( Seon Young Park ),( Sung Kyu Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Traditional symptom-based therapies of irritable bowel syndrome (IBS) are directed at the relief of individual IBS symptoms. However, prognostic factors for responses to these treatments have not yet been well studied. The purpose of this study was to evaluate predictors for treatment response in patients with IBS. Methods: A total of 183 patients diagnosed with IBS according to Rome III criteria and underwent lactulose breath test (LBT) from October 2010 to June 2014 were reviewed retrospectively. All participants had checked global IBS symptom questionnaire on the day of the LBT. Overall improvement of global IBS symptoms was reassessed after 4 weeks of treatment. Results: Sixty-one subjects (33.3%) were classified as diarrhea-predominant IBS (IBS-D), 38 (20.8%) as constipation-predominant IBS (IBS-C), 17 (9.3%) as mixed-symptoms IBS (IBS-M), and 67 (36.6%) as unspecifi ed type IBS (IBS-U). LBT results were not signifi cantly different in relation to IBS subtypes. One hundred and nineteen patients (65%) had positive LBT, while 64 patients (35%) had negative LBT. Among the 119 patients with positive LBT, overall symptom improvement was observed in 91 patients (76.5%). Subjects with underlying psychological problems were less likely to have symptom improvement (4/28 vs. 3/91 p=0.031). High basal hydrogen level (>20 ppm) was more frequent in the subjects without symptom improvement (6/28 vs. 6/91, p=0.023). However, underlying psychological problems and high basal hydrogen level were not signifi cantly associated with poor treatment response in patients with negative LBT. Conclusions: High basal hydrogen production correlates with poor treatment response in patients with IBS and positive LBT. This result suggests that LBT can be used as a tool for prediction of treatment response in patients with IBS and positive LBT.