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음식물 폐기물류로 제조된 퇴비의 고형연료 가치 평가 연구
이경섭,장한별,정은지,도아름,하진욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2
In 2019, the daily generation of food waste in Korea was 14,314 tons, which is a steady increase compared to the past. To efficiently use food waste as an effective resource, composting and feeding are carried out. In Korea, attention is gradually focused on a sustainable resource circulation society. Compost made of food waste has problems with foreign substances, heavy metals, and salt content, and solid fuelization research is being actively conducted to compensate for this. In this study, infrared spectroscopy(FT-IR), organic content measurement(TGA), and chemical composition were measured to compare the fuel characteristics with wood pellets, which are major solid fuels, in order to examine the physical and chemical properties of food waste compost.
Lee, Eun Byeol,Kim, Jun Hyeong,An, Chang Wan,Kim, Yeong Jee,Noh, Yun Jeong,Kim, Su Jin,Kim, Ju-Eun,Shrestha, Abinash Chandra,Ham, Ha-Neul,Leem, Jae-Yoon,Jo, Hyung-Kwon,Kim, Dae-Sung,Moon, Kwang Hyun,L The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.6
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Eun-Byeol Jo,Eun Jung Lee,Hyeri Won,Sunyoon Jung,Hee-Kyong Son,Jung-Heun Ha,Misook Kim,Youngseung Lee,Yoonhwa Jeong 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
NAFLD is now widely agreed as a metabolic associated fatty liver disease. Accumulation of excess fats in the liver elevates free fatty acids as a first hit and the prolonged first hit may triggers the second hit (i.e. oxidative stress, inflammation and/or ER stress). Gryllus bimaculatus (GB) contains a great sources of protein, unsaturated fatty acids, and essential fatty acids which possesses anti-oxidative and -inflammatory properties. Therefore, we raised an extended research hypothesis that GB would prevent tunicamycin-inducible ER stress and relevant pathological consequences. Regardless of GB consumption, tunicamycin injection induced a catabolic process by decreasing serum triglycerides, cholesterols and free fatty acids, but increased an anabolic process by increasing hepatic TG accumulation. Interestingly, hepatic ApoB, a strong predictor of inflammatory status, mRNA expression was suppressed by the GB supplementation. Therefore, we logically postulated that GB would prevent second hit in NAFLD; therefore, we focused on hepatic ER stress. As our expectation, GB consumption remarkably attenuated hepatic BiP, a cytosolic chaperone protein, expression.
Lee, Mi-Kyung,Kim, Hee-Eun,Park, Eun-Byeol,Lee, Janghyun,Kim, Ki-Hun,Lim, Kyungeun,Yum, Seoyun,Lee, Young-Hoon,Kang, Suk-Jo,Lee, Joon-Hwa,Choi, Byong-Seok Oxford University Press 2016 Nucleic acids research Vol.44 No.17
<P>Retinoic acid-inducible gene I (RIG-I) recognizes specific molecular patterns of viral RNAs for inducing type I interferon. The C-terminal domain (CTD) of RIG-I binds to double-stranded RNA (dsRNA) with the 5′-triphosphate (5′-PPP), which induces a conformational change in RIG-I to an active form. It has been suggested that RIG-I detects infection of influenza A virus by recognizing the 5′-triphosphorylated panhandle structure of the viral RNA genome. Influenza panhandle RNA has a unique structure with a sharp helical bending. In spite of extensive studies of how viral RNAs activate RIG-I, whether the structural elements of the influenza panhandle RNA confer the ability to activate RIG-I signaling has been poorly explored. Here, we investigated the dynamics of the influenza panhandle RNA in complex with RIG-I CTD using NMR spectroscopy and showed that the bending structure of the panhandle RNA negates the requirement of a 5′-PPP moiety for RIG-I activation.</P>
Lee, Janghyun,Park, Eun-Byeol,Min, Jiyoun,Sung, Si-Eun,Jang, Yejin,Shin, Jin Soo,Chun, Dongmin,Kim, Ki-Hun,Hwang, Jihyun,Lee, Mi-Kyung,Go, Yun Young,Kwon, Dohyeong,Kim, Meehyein,Kang, Suk-Jo,Choi, Byo Oxford University Press 2018 Nucleic acids research Vol.46 No.4
<P><B>Abstract</B></P><P>Retinoic acid-inducible gene I (RIG-I) recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5′ phosphates. A few reports of 5′-PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found that the bent duplex RNA from the influenza A panhandle promoter activates RIG-I even in the absence of a 5′-triphosphate moiety. Here, we report that non-canonical synthetic RNA oligonucleotides containing G-U wobble base pairs that form a bent helix can exert RIG-I-mediated antiviral and anti-tumor effects in a sequence- and site-dependent manner. We present synthetic RNAs that have been systematically modified to enhance their efficacy and we outline the basic principles for engineering RIG-I agonists applicable to immunotherapy.</P>