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- 학과정보 : 임상병리과 (검색결과 35 건)
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Correlation between HBV infection and blood test results Department of Biomedical Laboratory Science General Graduate School Dankook University Ham Seung Keun Advisor:Professor Jae Kyung Kim, Ph. D In this study, the relationship between the hepatitis B virus and hematological items were divided into three categories. Biochemical test items included C-reactive protein (CRP), Procalcitonin (PCT), and Lactate dehydrogenase (LDH). Thyroid function test (TFT) items included Thyroid stimulating hormone (TSH) and Free T4 (FT4). Creatine kinase (CK), Creatine kinase myocardial band (CK-MB), and Troponin I (TnI) were analyzed for cardiac marker items. Studies have been conducted to analyze blood test results and report differences in hepatitis B results. The purpose of this study was to help identify clinical symptoms based on differences in blood test results to treat clinical symptoms and characteristics corresponding to each blood test item. The samples used in the study were provided by 200 subjects, from June 2022 to August 2022. This study was approved by the Dankook University System Review Committee. All personal information except the date of birth and gender of the target group were encrypted and analyzed only with the test results. The distribution of the study group consisted of 104 people in the infected group (39 males and 65females) and 96 people in the non-infected group (60 males and 36 females). The age distribution of the entire target group was between 2 and 88 years old. The infected group consisted of forty-seven young people (45%) and 57 elderly people (55%). The average age of the target group was 53±36 years for HBV patients. The non-infected group included 29 (30%) young and 67 (70%) elderly people. The average age of non-infected people was 54±12. From the result of the study, it was observed that the CRP category was 300% higher in the infected group than in the non-infected group and 500% higher in the female infected group than in the male infected group. By age, the group subject to infection under the age of 50 was 100% higher than the group subject to infection over the age of 50. The PCT category for infected people was 333% higher than for non-infected people and for women was about 200% higher than for men by gender. Considering age, for those <50 PCT category results were 200% higher than those >50. In the LDH category, there was no significant difference between the infected and non-infected groups. Considering age groups, those <50 were 1% higher than those >50. In the TSH sector, the infected population was 4.5% higher than the non-infected population and about 25.0% higher for women than for men when considering gender. There was no significant difference comparing age. In the FT4 category, there was no difference in the results between the infected and non-infected groups. In the CK category, the infected group was 55.1% lower than the non-infected group, and for the female infected group, it was 64.3% lower than for the male infected group. For those <50 CK category results were 14% lower than for those >50. No relationships were found associated with the TnI results. The level of the infection target group of CK-MB items was lower than that of the non-infection target group. The non-infected group was 21.1% higher than the infected group. By age, for those aged 50 or older TnI results were about 27.8% higher than those under 50, and by gender, the infection rate was low for both men and women. As a result, the items that increased due to HBV infection were CRP, PCT, and TSH, and the items that decreased were CK and CK-MB. There was no correlation in other items. In conclusion, the purpose of this study was to support the treatment direction of HBV according to the characteristics of each category according to the results. For example, higher outcomes of CRP and PCT items due to viral infections rather than bacterial infections are one of the areas expected to be useful in terms of treatment and follow-up. In the case of CK items, there are a few other studies, and studies on exercise load are cited; thus, it is evaluated as useful for treatment in that it can induce varied research. In conclusion, this study attempted to categorize the results of blood test items according to HBV infection, analyze the clinical characteristics of HBV infected people, and understand the characteristics of patients due to HBV. The study is expected to help treat HBV patients.
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결핵 확진을 위한 MPT64와 TB/NTM RT-PCR의 유용성 및 전통적 배양방법의 효율성 분석
결핵을 유발하는 병원체인 Mycobacterium. tuberculosis는 면역체계를 회피할 수 있으며 잠복 감염으로 숙주 내에서 오랜 기간 동안 살 수 있다. M. tuberculosis의 잠복 상태를 뒷받침하는 분자 메커니즘을 밝히는 것은 결핵 감염에 대한 보다 효과적인 치료법을 개발하는 데 필수적이다. 본 연구에서 경기도 소재 H 대학병원의 미생물학 검사실에 2021년에 의뢰된 검체 6,174건을 대상으로 한 결핵검사의 양성율, 오염률, 내성율을 조사하였다. 항산성균 도말검사에서 양성이 342건(5.5%)였으며, Mycobacterium growth indicator tube (MGIT) 액체배지와 3% Ogawa 고체배지에서 모두 배양되어 검출된 검사는 243건(71.1%)이었고 MGIT배지 또는 3% Ogawa 배지에서만 배양된 경우는 각각 341건(99.7%), 234건(68.4%)로 나타났다. 두가지 배지 모두에서 양성으로 검출된 341건의 검체를 SD BIOLINE TB Ag MPT64 Rapid 검사를 수행하여 결핵균 양성으로 최종 판정된 것은 333건(97.7%)으로 나타났으며 또한 Advansure TB/NTM real-time PCR로 분석한 결과는 279건(81.8%)으로 나타났다. 결핵균으로 동정된 145건에 대하여 항결핵제의 감수성 검사를 수행한 결과 INH02((isoniazid))에 대한 내성률은 23건(15.9%), RIF (rifamycin)은 11건(7.6%), EMB (ethambutol;ETB) 10건(6.9%), RBT (rifabutin;RFB) 10건(6.9%)순으로 나타났다. 한편, 오염율 조사는 액체배지에서 255건(4.4%), 고체배지는 254건(4.4%)으로 나타났다. 결핵의 확진을 위해 다양한 검사법을 이용하고 있는데 전통적 배양 검사와 RT-PCR의 상관관계를 알아본 결과, 특히 액체배양 검사는 시간이 오래 걸리는 단점이 존재하지만 시간이 상대적으로 빠른 RT-PCR 보다 정확한 결과를 확인 할 수 있었다. 빠른 결핵의 동정으로 감수성 검사를 통해 적절한 항생제 처방을 할 수 있을 것이다. 결론적으로 결핵의 동정률을 높이기 위해 전통적 배양검사와 MPT64, RT-PCR 검사를 병행하는 것이 확진에 더 효율적일 것으로 생각된다. 이를 통해 축적된 정보를 활용해 약물 내성 결핵균의 내성획득 위험을 낮추며, 세균 제거를 통해 감염 기간을 단축하고 염증 및 폐 조직 손상을 감소시킬 수 있을 것이다. 이번 연구를 통해 현재보다 더 나은 임상 치료의 기초자료가 될 것으로 판단된다. Mycobacterium tuberculosis-causing pathogen, Mycobacterium tuberculosis, can evade the immune system and can live in the host for a long period of time as a latent infection. The elucidation of the molecular mechanisms that support the latent state of M. tuberculosis is essential for the development of more effective treatments for tuberculosis infection. In this study, the positive rate, contamination rate, and resistance rate of the tuberculosis test of 6,174 samples referred to the microbiology laboratory of H University Hospital in Gyeonggi-do in 2021 were investigated. There were 342 cases (5.5%) of positive in the acid-fast bacillus smear test, and 243 cases (71.1%) were detected by culturing in both Mycobacterium growth indicator tube (MGIT) broth and 3% Ogawa solid broth, and 341 cases (99.7%) and 234 cases (68.4%) were cultured in MGIT broth or 3% Ogawa broth, respectively. The SD BIOLINE TB Ag MPT64 rapid test of 341 samples detected as positive in both media was performed, and 333 (97.7%) were finally determined as positive for tuberculosis, and 279 (81.8%) were analyzed by Advansure TB/NTM real-time PCR. As a result of performing the sensitivity test of anti-tuberculosis drugs on 145 cases identified as tuberculosis bacteria, the resistance rate to INH02(isoniazid) was 23 cases (15.9%), RIF (ripamycin) was 11 cases (7.6%), EMB (ethambutol;ETB) 10 cases (6.9%), and RBT (ripabutin;RFB) 10 cases (6.9%). Meanwhile, the contamination rate survey was 255 cases (4.4%) in the liquid medium and 254 cases (4.4%) in the solid medium. Various test methods are used to confirm the confirmation of tuberculosis. As a result of examining the correlation between the traditional culture test and RT-PCR, in particular, the liquid culture test has the disadvantage of taking a long time, but in particular, it was possible to confirm the more accurate result than RT-PCR, which is relatively fast. With the rapid identification of tuberculosis, an appropriate antibiotic prescription can be made through a susceptibility test. In conclusion, in order to increase the identification rate of tuberculosis, it is thought that it would be more efficient to confirm the infection by combining the traditional culture test with MPT64, and RT-PCR tests. Through this, the accumulated information will be used to reduce the risk of acquiring resistance to drug-resistant tuberculosis bacteria, and through bacterial removal, the infection period can be shortened and inflammation and lung tissue damage can be reduced. This study is believed to provide the basic data for better clinical treatment than the present.
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