만성 B형 활동성 간염에서 poly ( A ). poly ( U ) 의 치료 효과 = Efficacy of Poly ( A ). Poly ( U ) in the Treatment of Chronic Active Hepatitis B

다국어 초록 (Multilingual Abstract)

The two major approaches to the treatment of chronic hepatitis B are 1) directed toward the eradication of the virus and 2) designed to modulate cellular and humoral immunity. Progress has been made in the development of antiviral chemotherapeutic agents for hepatitis B, but as yet no safe and reliably effective treatment or combmations of treatments are available. It has been demonstrated that interferon is useful in suppressing hepatitis B viral replication, but the relatively low response rate of Asian patients to interferon treatment has been documented due to the fact that mostly they acguired infections perinatally or during childhood. Poly(A). poly(U) is a double stranded helical ribopolyuncleotide complex, which stimulates both humoral and cell mediated immune response, and enhances the splenic NK activity as well as induces the production of the interferon. In this study, we have measured sequentially the leveils of alanine aminotransferase (ALT) and 2, 5-oligoadenylate synthetase (2-5 AS) activities and hepatitis B viral markers in patients with histologically proven chronic active heaptitis after weekly intravenous injection of poly(A). poly(U) to find out that poly(A). poly(U) may be used as the therapeutic agent in the treatment of chronic active hepatitis B. The results were as follows: ALT levels after the weekly administrations of poly(A).poly(U) have declined significantly to the normal level except one case as times passed, especially after 5 weeks. Serum 2-5 AS activities were elevated significantly after the administration of poly(A).poly(U). The complete responses were noted in four cases out of eleven cases (36.4%) until 5 months after discontinuance of poly(A).poly(U). The partial responses were noted in five cases (45.5%). No specific side effects were noted except the light-headness just one time in only one case. In conclusion, the administration of poly(A).poly(U) in the patients with chronic active hepatitis B seems to be effective, simple and safe method, although more extensive and detailed immunologic researches are required.