임신 중기 triple marker screenig test의 다운 증후군의 예측성에 대한 고찰 = Clinical analysis of triple marker screening test for fetal Down syndrome in midtrimester of pregnancy -Low sensitivity of triple marker screening test-

다국어 초록 (Multilingual Abstract)

Objective: To assess the reliability of triple marker screening test in midtrimester pregnancy for fetal Down syndrome. Methods: From October 1, 1996 to May 31, 1998 at Nowon Eulji Hospital, 3700 Pregnant women underwent serum tiple marker screening for Down syndrome during 15-20weeks of gestational age. The results of serum triple marker screenig tests for Down syndrome and the outcomes of pregnancies were retrospectively assesed. Results: Sixty seven of 3700 cases(1.81%) were positive in screening test, and 3633(98.18%) cases were negative. Among 67 cases of positive screening test , 1 case(1.49%) was diagnosed as Down syndrome. Among 3633 cases of negative screening test, 4 cases(0.1%) were diagnosed as chromosomal abnormalies postnatally. Two of these 4 cases of chromosomal abnormalies were Down syndrome. Conclusion: With this results, sensitivity of triple marker screeing test for Down syndrome is very low as 33.3%. In order to increase the sensitivity, some compensatory adjustment is required in triple marker screening test.