In the present study, efficacy of bacteriophages was evaluated in commercial chicks infected with Salmonella Enteritidis (SE). 1-day-old chicks challenged with 5 × 10? CFU of SE cohabited with contact chickens treated with different doses (105.0, 1...
In the present study, efficacy of bacteriophages was evaluated in commercial chicks infected with Salmonella Enteritidis (SE). 1-day-old chicks challenged with 5 × 10? CFU of SE cohabited with contact chickens treated with different doses (105.0, 10<SUP>7.0</SUP> 과 10<SUP>9.0</SUP> (pfu/g)) of bacteriophage prepared by feed additives for 21 days after challenge with SG. Chicks were euthanized at 7, 14 and 21 days after challenge for quantitative salmonella isolation from intestine and determination of environmental contamination level. Although low doses (10<SUP>5.0</SUP> pfu/g) of bacteriophges therapy could not decrease SE replication in intestines and environmental contamination, high doses of bacteriophage therapy (10<SUP>5.0</SUP>, 10<SUP>7.0</SUP> pfu/g) as additives in feed resulted in significant inhibition of the SE replication in intestines of SE infected and contact chicks (P < 0.05 or P < 0.01). In addition, environmental contamination by SE fecal shedding was decreased in bacteriophagetreated birds. Therefore, bacteriophage examined in this study may be a plausible alternative to antibiotics for the reduction of salmonella infection in poultry.