Seaweed and Iodine Intake and SLC5A5 rs77277498 in Relation to Thyroid Cancer

다국어 초록 (Multilingual Abstract)

Background: This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes,the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean population.
Methods: We conducted a case-control study of 117 thyroid cancer cases and 173 controls who participated in the Cancer ScreeneeCohort between 2002 and 2014 at the National Cancer Center, Korea. The amount of seaweed and iodine consumption (g/day) wasestimated using the residual energy adjustment method. We calculated odds ratios (ORs) and their 95% confidence intervals (CIs)using a multivariable logistic regression model for the separate and combined effect of dietary iodine-based intake and SLC5A5polymorphism (rs77277498, C>G) on thyroid cancer.
Results: Dietary gim and iodine intakes were inversely associated with thyroid cancer, with ORs of 0.50 (95% CI, 0.30 to 0.83) and0.57 (95% CI, 0.35 to 0.95), respectively, whereas the associations for dietary miyeok/dashima and total seaweed intakes were notsignificant. However, compared with individuals carrying the C/C genotype of the rs77277498 polymorphism with a low intake ofall dietary factors, those carrying the G allele with a high intake had a lower risk of thyroid cancer, with ORs of 0.25 (95% CI, 0.10to 0.56), 0.31 (95% CI, 0.12 to 0.77), 0.26 (95% CI, 0.10 to 0.62), and 0.30 (95% CI, 0.12 to 0.73) for the consumption of gim, miyeok/dashima, total seaweed, and iodine, respectively.
Conclusion: In summary, our results supported the evidence of the protective effects of dietary gim and iodine intake against thyroidcancer risk, and this association can be strengthened by SLC5A5 rs77277498 genotypes.

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