치주질환과 용해소체효소 : 치주질환 활성에 관한 실험적 연구 Experimental tudy on the Activity of Periodontal Disease = Lysosmal Acid Hydrolases and Periodontal Disease

다국어 초록 (Multilingual Abstract)

This study was undertaken to investigate the periodontal disease activity on 4 dogs which was induced experimental periodontitis by ligation the 3rd and 4th premolars of maxilla and mandible with wire. It is meaningful approach to measure biochemical status as an indicator of periodontal disease activity. Arylsulfatase, a marker associated with tissue breakdown, was analysed from gingival crevicular fluid of dogs.
By the modification of the method of Griffiths, arylsulfatase was assayed spectro-photometically and compared with clinical parameters such as periotron unit, PI, SBI, or PD.
The results of this study were as follows :
1. Average values of arylsulfatase activity (optical density) were statistically significant between the experimental (0.003 ± 0.015) and control (0.022 ± 0.006) site on the 16th week. (P < 0.01)
2. Periotron units, SBI and PI were statistically significant between experimental and control site from the 2th week to the 16th week. (P < 0.01) But PD was statistically significant on the 12th week (P < 0.01)
3. Correlation coefficients between arylsulfatase and clinical index was statistically significant, but less significant than that of PU and cinical index
4. It is suggested that the periodontal disease activity is episodic pattern according to arylsulfatase and periotron unit.