高糖質植餌가 脂肪組織에 있어서 脂質合成에 미치는 영향 = Effect of Dietary Carbohydrate on the Lipogenesis of Adipose Tissue in Rats

국문 초록 (Abstract)

〔U-^14C〕glucose의 탄소원자가 지방조직의 지질에의 편입에 대하여 절식 및 고당질식이 투여가 어떠한 영향을 미치는가를 쥐를 사용해서 조사해본 결과는 다음과 같았다.
지방조직의 지질에 glucose 탄소원자의 편입속도는 정상섭식상태에 비하여 24시간 절식상태에서 약 3분의 1로 현저하게 감소되었으며, 절식후 고당질식이를 24시간 투여하면 이편입속도는 약 2배로 증가되었다. 그러나, 고당질식이로 장기간 사육하면 이편입률은 오히려 저하되는 경향을 보였다.
이상의 결과는 쥐에서 glucose의 지질합성으로의 이용이 기아상태에서는 현저하게 저하되고 많은 당질을 섭취할때는 뚜렷하게 증가되나 장기간 섭취하면 오히려 저하됨을 뜻하고 있다.

다국어 초록 (Multilingual Abstract)

The object of present study was to evaluate the effect of high-carbohydrate diet on the rate of lipogenesis from glucose carbon in adipose tissue of rats using 〔U-^14C〕glucose under four different nutritional state. All rats were injected 4 microcuries of 〔U-^14C〕glucose mixed with 10mg of glucose per body weight of 100g, three hours later the amount of lipid extracted from mesenteric adipose tissue of 500mg was checked, and radioactivity of the 〔^14C〕lipid was measured with gas flow counter.
The rate of lipogenesis in adipose tissue was significantly low in rats fasted 24 hours. However, the reverse was true in case of high-dietary carbohydrate treatment to 24-hour fasted rats compared to rats fed control diet. Rats previously fed the high-carbohydrate diet for 4 weeks showed general decrease in the rate of lipogenesis although lipid content was more elevated in adipose tissue than that of the control diet rats.
These results indicated that the rate of lipogenesis in adipose tissue changes significantly under various nutritional states, especially high-carbohydrate diet leads to elevate the rate of lipogenesis but prolonged administration of the diet might tend to depress the rate of lipogensis with increase of lipid content in adipose tissue.