한국 비만 여성에서 열량제한 식사에 의한 근육 간 지방량의 감소 = Decreased Intermuscular Adipose Tissue due to Caloric Restriction in Obese Korean Women

다국어 초록 (Multilingual Abstract)

Background: This study investigated the effects of caloric restriction on thigh intermuscular adipose tissue (IMAT) and the associations ofIMAT and metabolic risk factors. Methods: Thirty-three obese Korean women (BMI 27.2±2.5 kg/m2; 32.3±8.7 years) were tested before andafter 12 weeks of 354.7 kcal/day dietary caloric restriction: waist circumference (WC); %fat according to bioimpedence; subcutaneous adiposetissue (SAT); visceral adipose tissue (VAT); IMAT using single-slice CT scans at the levels of L4/L5 and mid-thigh (midpoint between the anterioriliac crest and patella); fasting levels of leptin, glucose, insulin, triglycerides, total-C, LDL-C, HDL-C, and HOMA-IR. Paired t-test andSpearman correlation analysis were performed. Results: WC, %fat, leptin, glucose, total-C, abdominal SAT and VAT, and mid-thigh IMATdecreased (P<0.05), and %change in mid-thigh IMAT correlated with %change in HOMA-IR (P<0.05). Conclusion: Caloric restrictiondecreased the mid-thigh IMAT in obese Korean women, which may be correlated with reduction of metabolic risk.

국문 초록 (Abstract)

배경: 비만 여성에서 열량 제한에 따른 근육 간 지방의 변화를 알아보고, 근육 간 지방과 대사적 지표와의 연관성 에 대해 알아보고자 하였다.
방법: 열량 제한 식사 교육프로그램을 참여한 33명의 체질량지수 25이상인 폐경 전 성인 여성 중, CT 결과 수집이 가능한 대상자만을 선택하여 자료를 재분석하였다. SLICEOMATIC 이미지 분석법을 통하여 재분석하여 피하지방과 내장지방, 근육 간 지방량을 측정하였다.
결과: 체중과 BMI, 허리둘레, 엉덩이 둘레, 허리-엉덩이 둘레비, 키-허리둘레비와 체지방량과 체지방률 모두 유의적 감소를 보였으며, 피하지방과 내장지방, 근육 간 지방량도 유의적 감소를 보였다. 근육 간 지방량의 감소는 HOMA-IR 감소와 유의적인 관련성을 보였다.
결론: 12주간의 열량 제한 식사로 인하여 비만 성인 여성에서 내장지방뿐 아니라 근육 간 지방량도 감소하였으며, 이는 인슐린 저항성의감소와도 관련이 있었다.

참고문헌 (Reference)

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