난소적출 생쥐에서 백수오와 홀포 혼합물의 조골세포 활성에 미치는 영향

다국어 초록 (Multilingual Abstract)

Osteoporosis is one of the most common diseases worldwide. In particular, the prevalence of osteoporosis increases in the elderly population. As republic of Korea is currently progressing into a super-aged society, the importance of preventing and treating osteoporosis is increasing. The purpose of this study is to confirm whether BaekhasuoHolpo mixture(BH) which is composed of Cynanchum wilfordii Hemsl. and Humulus lupulus L. would improve osteoporosis. To this aim, BH was orally administered to mice with ovariectomized(OVX)-induced osteoporosis for 7 weeks. And then bone mineral density(BMD), cortical porosity, and serum levels of osteoprotegerin(OPG), osteocalcin(OC) and alkaline phosphatase(ALP) were measured. The levels of OPG, OC and ALP in the serum especially are related to activity of osteoblasts. ALP, OPG and OC significantly were increased in serum of BH-treated OVX mice. Also administration of BH significantly improves the levels of BMD and reduced total cortical porosity in the OVX mice. In conclusion, this study indicates that BH has an beneficial effect on activity of osteoblasts in OVX mice.

목차 (Table of Contents)

• Ⅰ. 緖 論 1
• Ⅱ. 實 驗 4
• 1. 材料 4
• 2. 方法 4
• 2-1 실험 동물 프로토콜 4
• 2-2 혈청분석 및 마이크로컴퓨터 단층 촬영 5
• 3. 統計 5
• Ⅲ. 結 果 6
• 1. 백수오와 홀포 복합물(BH)의 혈청 ALP 활성도에 미치는 영향 6
• 2. 백수오와 홀포 복합물(BH)의 혈청 OPG/OC 활성도에 미치는 영향 7
• 3. 백수오와 홀포 복합물(BH)의 BMD/total cortical porosity에 미치는 영향 9
• Ⅳ. 考 察 11
• Ⅴ. 結 論 14
• 參考文獻 15
• ABSTRACT