AFP and Histologic Grade Are Significant Predictors for Intrahepatic Recurrence of Hepatocellular Carcinoma after a Hepatectomy = AFP and Histologic Grade Are Significant Predictors for Intrahepatic Recurrence of Hepatocellular Carcinoma after a Hepatectomy

다국어 초록 (Multilingual Abstract)

Aims: The alpha fetoprotein(AFP) elevation in hepatocellular carcinoma(HCC) has been shown to correlate with poor tumor differentiation, early intrahepatic recurrence after a hepatectomy. We aimed to examine the AFP levels, tumor burden, histologic grade, and other clinicopathological variables compare with two groups of HCC patients either with low or high AFP. This comparison helps us to predict intrahepatic recurrence of HCC.
Methods: We retrospectively reviewed medical records of HCC patients who received hepatectomy between January 2009 and December 2015. Perioperative data were collected from the patients.
Results: Of 181 recipients, we divided two groups either with low or high AFP. Histological variables were analyzed with serum AFP. We observed intrahepatic recurrence rates, disease free survival, and 3years/5years overall survival rates for 7years.
Conclusions: In high AFP and poorly differentiated HCC patients had early intra-hepatic recurrence and low survival rates. Prospective study for AFP genes of HCC patients would be planned.