Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study

다국어 초록 (Multilingual Abstract)

In the current study, selenium particles were loaded into poly(ε-caprolactone)/gelatin nanofibrous matrices in orderto fabricate a potential wound dressing. The mats were produced by electrospinning of poly(ε-caprolactone)/Gelatin (1:1(w/w)) solution supplemented with 1 and 10 % (w/v) of selenium particles. Prepared wound dressings were investigatedregarding their morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability,porosity, blood compatibility, microbial penetration test and cellular response. Dressings containing 1 % and 10 % seleniumand selenium free mats were chosen to treat the full-thickness excisional wounds in Wistar rats. The study revealed that after14 days, the wound closure of the mat containing 1 % selenium was about 95.5±6.38 % while wound closure of the negativecontrol group was about 48.83±4.03 %. Our results showed the capability of nanofibrous containing selenium for successfulwound treatment.

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