배양 노랑다발동충하초 부탄올분획의 급성경구독성 = Acute Oral Toxicity of the Butanol Fraction from Cultured Fruitbody Cordyceps bassiana in Mice

다국어 초록 (Multilingual Abstract)

Cordyceps bassiana is a parasitic fungus and used as a Chinese traditional medicine. It has been called as Dong-
ChungHaCho(summer-plant, winter-worm) in China. Acute oral toxicity was examined in male and female ICR mice. Butanol
fraction from Cordyceps bassiana(BuCb) was administered orally at a dose of 2,500 mg/kg, 5,000 mg/kg, 10,000 mg/kg. No
death and abnormal clinical signs were observed throughout the administration period. The acute toxicity test on mouse did not
show any oversign in net body weight gain, food and water consumptions, organ weights, gross pathological findings by different
doses of BuCb. Also, biochemical examination revealed no evidence of specific toxicity. These findings show that BuCb
has wide margin of safety on acute toxicity with single exposure.

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