Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

다국어 초록 (Multilingual Abstract)

Over the last two decades, numerous studies have investigated the presence of human cytomegalovi- rus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few re- searchers have suggested the potential benefits of cytotoxic T lymphocyte or dendritic cell-based vac- cines for recurrent or newly diagnosed glioblastoma patients, several studies did not at all agree with the existence of CMV in glioblastoma cells. In this review, we summarized the conflicting results and issues about the detection of CMV in glioblastoma or glioma patients. We also provided the clinical data of published and unpublished clinical trials using CMV-specific immunotherapy for glioblastomas.

참고문헌 (Reference)

1 Moore PS, "Why do viruses cause cancer? Highlights of the first century of human tumour virology" 10 : 878-889, 2010

2 Yuan Z, "Virome assembly and annotation in brain tissue based on next-generation sequencing" 9 : 6776-6790, 2020

3 Michaelis M, "The story of human cytomegalovirus and cancer : increasing evidence and open questions" 11 : 1-9, 2009

4 Rahman M, "The role of CMV in glioblastoma and implications for immunotherapeutic strategies" 8 : e1514921-, 2018

5 Tang KW, "The landscape of viral expression and host gene fusion and adaptation in human cancer" 4 : 2513-, 2013

6 Herbein G, "The human cytomegalovirus, from oncomodulation to oncogenesis" 10 : 408-, 2018

7 Lucas KG, "The detection of CMV pp65 and IE1 in glioblastoma multiforme" 103 : 231-238, 2011

8 Mitchell DA, "Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients" 519 : 366-369, 2015

9 Qin Z, "TLR3 regulates PD-L1 expression in human cytomegalovirus infected glioblastoma" 11 : 5318-5326, 2018

10 Ranganathan P, "Significant association of multiple human cytomegalovirus genomic loci with glioblastoma multiforme samples" 86 : 854-864, 2012

11 Mitchell DA, "Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma" 10 : 10-18, 2008

12 Strojnik T, "Prevalence of neurotropic viruses in malignant glioma and their onco-modulatory potential" 31 : 221-229, 2017

13 Loit MP, "Multimodal techniques failed to detect cytomegalovirus in human glioblastoma samples" 25 : 50-56, 2019

14 Ghaffari H, "Molecular investigation of human cytomegalovirus and Epstein-Barr virus in glioblastoma brain tumor : a case-control study in Iran" 25 : 426-433, 2021

15 Cobbs CS, "Methods for the detection of cytomegalovirus in glioblastoma cells and tissues" 1119 : 165-196, 2014

16 Rahbar A, "Low levels of human cytomegalovirus infection in glioblastoma multiforme associates with patient survival;-a case-control study" 3 : 3-, 2012

17 Batich KA, "Long-term survival in glioblastoma with cytomegalovirus pp65-targeted vaccination" 23 : 1898-1909, 2017

18 Khoury JD, "Landscape of DNA virus associations across human malignant cancers:analysis of 3,775 cases using RNA-Seq" 87 : 8916-8926, 2013

19 Yamashita Y, "Lack of presence of the human cytomegalovirus in human glioblastoma" 27 : 922-929, 2014

20 Johnson TS, "Lack of human cytomegalovirus expression in single cells from glioblastoma tumors and cell lines" 23 : 671-678, 2017

21 Garcia-Martinez A, "Lack of cytomegalovirus detection in human glioma" 14 : 216-, 2017

22 Poltermann S, "Lack of association of herpesviruses with brain tumors" 12 : 90-99, 2006

23 Lau SK, "Lack of association of cytomegalovirus with human brain tumors" 18 : 838-843, 2005

24 Limam S, "Investigation of human cytomegalovirus and human papillomavirus in glioma" 38 : 394-405, 2020

25 Bahador M, "Increased infiltration and tolerised antigenspecific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients" 6 : e1336272-, 2017

26 El Baba R, "Immune landscape of CMV infection in cancer patients : from"canonical"diseases toward virus-elicited oncomodulation" 12 : 730765-, 2021

27 Adnan Ali SM, "Human papillomavirus and human cytomegalovirus infection and association with prognosis in patients with primary glioblastoma in Pakistan" 121 : e931-e939, 2019

28 Lin CT, "Human herpesvirus multiplex ddPCR detection in brain tissue from low-and highgrade astrocytoma cases and controls" 11 : 32-, 2016

29 Libard S, "Human cytomegalovirus tegument protein pp65 is detected in all intra-and extra-axial brain tumours independent of the tumour type or grade" 9 : e108861-, 2014

30 Rahbar A, "Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival" 57 : 36-42, 2013

31 Baumgarten P, "Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics" 16 : 1469-1477, 2014

32 Maleki F, "Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness" 92 : 1266-1276, 2020

33 Xing Y, "Human cytomegalovirus infection contributes to glioma disease progression via upregulating endocan expression" 177 : 113-126, 2016

34 Cobbs CS, "Human cytomegalovirus infection and expression in human malignant glioma" 62 : 3347-3350, 2002

35 Hu M, "Human cytomegalovirus immediate-early protein promotes survival of glioma cells through interacting and acetylating ATF5" 8 : 32157-32170, 2017

36 Bianchi E, "Human cytomegalovirus and primary intracranial tumours : frequency of tumour infection and lack of correlation with systemic immune anti-viral responses" 41 : e29-e40, 2015

37 Stangherlin LM, "Human cytomegalovirus DNA quantification and gene expression in gliomas of different grades" 11 : e0159604-, 2016

38 Wen L, "Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis" 11 : 525-533, 2020

39 dos Santos CJ, "High prevalence of HCMV and viral load in tumor tissues and peripheral blood of glioblastoma multiforme patients" 86 : 1953-1961, 2014

40 Slinger E, "HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis" 3 : ra58-, 2010

41 Bhattacharjee B, "Genetic analysis of cytomegalovirus in malignant gliomas" 86 : 6815-6824, 2012

42 Ghazi A, "Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastoma" 35 : 159-168, 2012

43 Taha MS, "Expression of cytomegalovirus in glioblastoma multiforme : myth or reality?" 30 : 307-312, 2016

44 Malekpour Afshar R, "Evaluation of JC and cytomegalo viruses in glioblastoma tissue" 17 : 4907-4911, 2016

45 Goerig NL, "Early mortality of brain cancer patients and its connection to cytomegalovirus reactivation during radiochemotherapy" 26 : 3259-3270, 2020

46 Ding D, "Does the existence of HCMV components predict poor prognosis in glioma?" 116 : 515-522, 2014

47 Cimino PJ, "Detection of viral pathogens in high grade gliomas from unmapped nextgeneration sequencing data" 96 : 310-315, 2014

48 Yang CF, "Detection of human cytomegalovirus in glioblastoma among Taiwanese subjects" 12 : e0179366-, 2017

49 Shamran HA, "Detection of human cytomegalovirus in different histopathological types of glioma in Iraqi patients" 2015 : 642652-, 2015

50 Scheurer ME, "Detection of human cytomegalovirus in different histological types of gliomas" 116 : 79-86, 2008

51 Sabatier J, "Detection of human cytomegalovirus genome and gene products in central nervous system tumours" 92 : 747-750, 2005

52 Mohammad AA, "Detection of circulating hcmv-miR-UL112-3p in patients with glioblastoma, rheumatoid arthritis, diabetes mellitus and healthy controls" 9 : e113740-, 2014

53 Reap EA, "Dendritic cells enhance polyfunctionality of adoptively transferred T cells that target cytomegalovirus in glioblastoma" 1 (1): 256-264, 2018

54 Han S, "Decreased human leukocyte antigen A*02 : 01 frequency is associated with risk of glioma and existence of human cytomegalovirus : a case-control study in Northern China" 66 : 1265-1273, 2017

55 Matlaf LA, "Cytomegalovirus pp71 protein is expressed in human glioblastoma and promotes pro-angiogenic signaling by activation of stem cell factor" 8 : e68176-, 2013

56 Solomon IH, "Cytomegalovirus and glioblastoma : a review of evidence for their association and indications for testing and treatment" 73 : 994-998, 2014

57 Dziurzynski K, "Consensus on the role of human cytomegalovirus in glioblastoma" 14 : 246-255, 2012

58 Cosset É, "Comprehensive metagenomic analysis of glioblastoma reveals absence of known virus despite antiviral-like type I interferon gene response" 135 : 1381-1389, 2014

59 Wakefield A, "CMV a target in pediatric glioblastoma? Expression of CMV proteins, pp65 and IE1-72 and CMV nucleic acids in a cohort of pediatric glioblastoma patients" 125 : 307-315, 2015

60 Schuessler A, "Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma" 74 : 3466-3476, 2014

61 Smith C, "Autologous CMV-specific T cells are a safe adjuvant immunotherapy for primary glioblastoma multiforme" 2 (2): 6041-6053, 2020

62 Huang R, "Association between human cytomegalovirus infection and histone acetylation level in various histological types of glioma" 10 : 2812-2820, 2015

63 Zavala-Vega S, "An overview of the infection of CMV, HSV 1/2 and EBV in Mexican patients with glioblastoma multiforme" 213 : 271-276, 2017

64 Tang KW, "Absence of cytomegalovirus in highcoverage DNA sequencing of human glioblastoma multiforme" 136 : 977-981, 2015

65 HoldhoffM, "Absence of cytomegalovirus in glioblastoma and other high-grade gliomas by real-time PCR, immunohistochemistry, and in situ hybridization" 23 : 3150-3157, 2017

66 Strong MJ, "A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus-tumor association" 4 : 71-, 2016