The 4-(2''-(N-(l-methyl-3''-carbamylphenyl)-n-propyl))aminoethyl)-l-hydroxy-2-pyridone which has isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O-Methyltransferase(COMT) vulnerable m-hydroxy group was syn...
The 4-(2''-(N-(l-methyl-3''-carbamylphenyl)-n-propyl))aminoethyl)-l-hydroxy-2-pyridone which has isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O-Methyltransferase(COMT) vulnerable m-hydroxy group was synthesized via 12 synthetic steps.