Prevention of Rocuronium-Induced Withdrawal Movement in Children : a Comparison of Remifentanil with Alfentanil

다국어 초록 (Multilingual Abstract)

Purpose: This study was designed to compare the efficacy of remifentanil and alfentanil without the venous occlusion technique in preventing the withdrawal response associated with rocuronium injection in children.Rocuronium-Induced Materials and Methods: One hundred twenty children aged between 3 and 10 years were randomly allocated into 1 of 4 groups to receive either i.v. remifentanil 0.5 μg·kg^(-1) (remi 0.5 group), remifentanil 1 μg·kg^(-1) (remi 1.0 group), alfentanil 15 μg·kg^(-1) (alfentanil group) or saline 5 ml (saline group). Anesthesia was induced with 2.5% thiopental sodium 5 mg·kg^(-1) and the test drug was injected over 30 sec. One minute after, 1% rocuronium 0.6 mg·kg^(-1) was injected over 5 sec and the response was recorded. Mean arterial pressure and heart rate were recorded on arrival in the operating room, before and 1 min after the tracheal intubation.
Results: The incidence of withdrawal movement in the saline group (93%) was significantly higher than that in the remi 0.5, remi 1.0, and alfentanil groups (53%, 17%, and 20%, respectively) (P < 0.05). The incidence in the remi 1.0 and alfentanil groups was significantly less than that in the remi 0.5 group (P < 0.05). After intubation, mean arterial pressure and heart rate were significantly higher in the saline group than that in remi 1.0 and alfentanil groups.
Conclusions: Both remifentanil 1 μg·kg^(-1) and alfentanil 15 μg·kg^(-1) can be used to prevent rocuronium associated withdrawal movement in children because they are equally effective and attenuate the increase in MAP and HR after intubation.

목차 (Table of Contents)

• Ⅰ. Introduction = 1
• Ⅱ. Materials and methods = 3
• Ⅲ. Results = 6
• Ⅳ Discussion = 11
• Ⅴ. Abstract = 16
• Ⅵ. References = 18