백서에서 Chlorpromzaine,Haloperidol,Clozapine이 뇌파에 미치는 영향 = Effects of Chlorpromazine,Haloperiodol,and Clozapine on the EEG in Rat

다국어 초록 (Multilingual Abstract)

To evaluate the differential elects of chlorpromazine, haloperidol, and clozapine on electroencephalographic (EEG) changes, EEG findings were compared in normal, relaxant, and schizophrenic animal models produced with MK-801 by using power spectral EEG analysis. Under pentobarbital anesthesia, the screw electrodes were implanted on the skull over the frontal cortex for EEG recording. The EEG was recorded before and after intraperitoneal administration of clozapine(5mg/kg), chlorpromazine(5mg/kg) and haloperidol(1mg/kg) in rats while awake(the normal group), rats pretreated with a relaxant pancuronium bromide(the relaxant group) and rats pretreated wish MK-801(0.2mg/kg, i.p., the MK-801 group). Spectrum analysis of the EEG was used to calculate the powers of each band (delta 1-4Hz; theta 4-8Hz; alpha 8-l3Hz; beta L 13-21Hz; beta H 21-30Hz; gamma 30-50Hz; and total 1-50Hz). The EEG activity was presented as the log value of the relative band power.
In the relaxant group, clozapine increased the activity of the delta, theta and alpha bands. Chlorpromazine increased the activity of the betaL band as well as the delta, theta and alpha bands and it decreased the activity of the gamma band. However, haloperidol did not change the activity of all bands significantly. In the MK-801 group, clozapine increased the activity of the delta and gamma bands and chlorpromazine increased the activity of the delta, betah and gamma bands significantly, Haloperidol increased the activity of the alpha and betaL bands significantly. To evaluate the differential effects of antipsychotics on EEG between the groups, the ratio of power change after a drug as referenced to pre-drug power in each group was calculated and compared between the groups and was represented by star-like display. In the star-like display, clozapine showed the smallest change and caused a slight shift upwards and to the left, chlorpromazine showed irregular changes, haloperidol showed similar increases along each band.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 1.대상
• 2.뇌파기록
• 3.파워스펙트럼 분석
• 4.통계분석
• 성적
• 1.정상군에서 항정신병약물에 의한 뇌파변화
• 2.이완제군에서 항정신병약물에 의한 뇌파변화
• 3.MK-801 처치에 의한 뇌파변화
• 4.MK-801군에서 항정신병약물에 의한 뇌파변화
• 고찰