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      KCI등재 SCIE SCOPUS

      Cholesterol-lowering Efficacy of Unrefined Bran Oil from the Pigmented Black Rice (Oryza sativa L cv. Suwon 415) in Hypercholesterolemic Rats

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      https://www.riss.kr/link?id=A82752555

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      다국어 초록 (Multilingual Abstract)

      The effects of dietary supplementation of the unrefined rice bran oil from ‘Suwon 415’ pigmented black rice (BRBO) on cholesterol metabolism and cellular antioxidant status were investigated in hypercholesterolemic rats. The significant reduction ...

      The effects of dietary supplementation of the unrefined rice bran oil from ‘Suwon 415’ pigmented black rice (BRBO) on cholesterol metabolism and cellular antioxidant status were investigated in hypercholesterolemic rats. The significant reduction of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations was observed in the plasma of rats fed BRBO. BRBO also decreased plasma and hepatic oxidative stress as a result of increased levels of hepatic thiobarbituric acid reactive substances (TBARS) levels associated with the elevations of hepatic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities together with increased plasma level of tocopherol. This study indicates that dietary BRBO supplement can leads to the improvement of overall cholesterol metabolism and antioxidant status even more effectively than ‘Chuchung’ white rice (WRBO). Consumption of BRBO may also protect the liver from oxidative damage caused by lipid peroxidation.

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      목차 (Table of Contents)

      • Abstract
      • Introduction
      • Materials and Methods
      • Results and Discussion
      • Acknowledgments
      • Abstract
      • Introduction
      • Materials and Methods
      • Results and Discussion
      • Acknowledgments
      • References
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      참고문헌 (Reference)

      1 Tremblay AJ, "Validation of the Fridewald formula for the determination of low density lipoprotein cholesterol compared with quantitation in large population" 37 : 785-790, 2004

      2 Sessions VA, "The effects of different dietary fats and cholesterol on serum lipoprotein concentration in hamsters" 1211 : 207-214, 1994

      3 Nguyen TT, "The cholesterol-lowering action of plant stanol esters" 129 : 2109-2112, 1999

      4 Paglia ED, "Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase" 70 : 158-169, 1967

      5 Seetharamaiah GS, "Studies on hypocholesterolemic activity of rice bran oil" 78 : 219-223, 1989

      6 Bieri JG, "Simultaneous determination of α-tocopherol and retinal in plasma or red cells by high pressure liquid chromatography" 32 : 2143-2149, 1979

      7 Braunwald E, "Shattuck lecture-cardiovascular medicine at the turn of the millennium: Triumphs, concerns, and opportunities" 337 : 1360-1369, 1997

      8 Li CC, "Rice production. Vol. 1, In: Genetics and Breeding" Nostrand Reinhold 23-, 1991

      9 Nicolosi RJ, "Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in nonhuman primates" 88 : 133-142, 1991

      10 Hegsted DM, "Quantitative effects of dietary fat on serum cholesterol in man" 17 : 281-295, 1965

      1 Tremblay AJ, "Validation of the Fridewald formula for the determination of low density lipoprotein cholesterol compared with quantitation in large population" 37 : 785-790, 2004

      2 Sessions VA, "The effects of different dietary fats and cholesterol on serum lipoprotein concentration in hamsters" 1211 : 207-214, 1994

      3 Nguyen TT, "The cholesterol-lowering action of plant stanol esters" 129 : 2109-2112, 1999

      4 Paglia ED, "Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase" 70 : 158-169, 1967

      5 Seetharamaiah GS, "Studies on hypocholesterolemic activity of rice bran oil" 78 : 219-223, 1989

      6 Bieri JG, "Simultaneous determination of α-tocopherol and retinal in plasma or red cells by high pressure liquid chromatography" 32 : 2143-2149, 1979

      7 Braunwald E, "Shattuck lecture-cardiovascular medicine at the turn of the millennium: Triumphs, concerns, and opportunities" 337 : 1360-1369, 1997

      8 Li CC, "Rice production. Vol. 1, In: Genetics and Breeding" Nostrand Reinhold 23-, 1991

      9 Nicolosi RJ, "Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in nonhuman primates" 88 : 133-142, 1991

      10 Hegsted DM, "Quantitative effects of dietary fat on serum cholesterol in man" 17 : 281-295, 1965

      11 Parrado J, "Prevention of brain protein and lipid peroxidation elicited by water-soluble oryzanol enzymatic extract derived from rice bran" 42 : 307-312, 2003

      12 Turpeinen AM, "Plasma and lipoprotein lipid peroxidation in humans on sunflower and rapeseed oil diets" 30 : 485-492, 1995

      13 Beveridge JMR, "Plant sterols, degree of unsaturation, and hypocholesterolemic action of certainfats" 36 : 895-911, 1958

      14 Miyazawa T, "Phospholipid hydroperoxide accumulation in liver of rats intoxicated with carbon tetrachloride and its inhibition by dietary α-tocopherol" 107 : 689-693, 1990

      15 Gu XY, "Phenotypic selection for dormancy introduced a set of adaptive haplotypes from weedy into cultivated rice" 171 : 695-704, 2005

      16 Rong N, "Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters" 32 : 303-306, 1997

      17 Raghuram TC, "Nutritional significance of rice bran oil" 102 : 241-244, 1990

      18 Qureshi AA, "Novel tocotrienols of rice bran inhibit atherosclerotic lesions in C57BL/6 Apo Edeficient mice" 131 : 2606-2618, 2001

      19 Oparil S, "Nontraditional cardiovascular risk factors" 317 : 193-207, 1999

      20 de Deckere EAM, "Minor constituents of rice bran oil as functional foods" 54 : S120-S126, 1996

      21 Nguyen LB, "Mechanism for cholesterol homeostasis in rat jejunal mucosa: Effects of cholesterol, sitosterol, and lovastatin" 42 : 195-200, 2001

      22 Marklund S, "Involvement of the superoxide anion radical in the autoxidation of pyrogallol and an assay for superoxide dismutase" 47 : 469-474, 1974

      23 O'Brien BC, "Interrelated effects of food lipids on steroid metabolism in rats" 107 : 1444-1454, 1977

      24 Ikeda I, "Inhibition of cholesterol absorption by plant sterols for mass intervention" 9 : 527-531, 1998

      25 Kahlon TA, "Influence of rice bran, oat bran, and wheat bran on cholesterol and triglycerides in humans" 76 : 439-443, 1990

      26 Sharma RD, "Hypocholesterolemic activity of unsaponifiable matter of rice bran oil" 85 : 278-281, 1987

      27 Lichtenstein AH, "Gualtieri LJ, Jenner JL, Ordovas JM, Schaeffer EJ. Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans" 14 : 549-556, 1994

      28 Nagao K, "Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a highcholesterol diet" 120 : 579-586, 1998

      29 Nagao K, "Feeding unsaponifiable compounds from rice bran oil does not alter hepatic mRNA abundance for cholesterol metabolism-related proteins in hypercholesterolemic rats" 65 : 371-377, 2001

      30 Allain CC, "Enzymatic determination of total serum cholesterol" 20 : 470-475, 1974

      31 Lin C-Y, "Effects of soy components on blood and liver lipids in rats fed high-cholesterol diets" 11 : 5549-5552, 2005

      32 Purushothama S, "Effect of long term feeding of rice bran oil upon lipids and lipoproten in rats" 146 : 63-69, 1995

      33 Mattson FH, "Comparison of effects of dietary saturated, monounsaturated, and polyunsatyrated fatty acids on plasma lipids and lipoproteins in man" 26 : 194-202, 1985

      34 Noguchi N, "Chemistry of active oxygen species and antioxidants. In: Antioxidant Status, Diet, Nutrition, and Health" CRC Press 3-36, 1999

      35 Abei H, "Catalase. Vol II, In: Method of Enzymatic Analysis" Academic Press 673-684, 1974

      36 Breslow JL, "Cardiovascular disease burden increases, NIH funding decreases" 3 : 600-601, 1997

      37 Ross R, "Atherosclerosis - an inflammatory disease" 340 : 115-126, 1999

      38 Ohkawa H, "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction" 95 : 351-358, 1979

      39 Folch J, "Asimple method for isolation and purification of total lipids from animal tissues" 226 : 497-506, 1957

      40 McGowan MW, "A peroxidecoupled method for the colorimetric determination of serum triglycerides" 29 : 538-542, 1983

      41 Waenic RG, "A comprehensive evaluation of the heparinmanganese precipitation procedure for estimating a high density lipoprotein cholesterol" 19 : 65-76, 1978

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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.75 0.17 0.56
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.49 0.43 0.364 0.06
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