Intracochlear Fluid Pressure and Cochlear Input Impedance from Push-pull Amplification Model

다국어 초록 (Multilingual Abstract)

Intracochlear fluid pressure and cochlear input impedance are simulated and compared with in-vivo physiological measurements. The objective of this work is to compare the calculations and measurements for the cochlear fluid pressure (PST) and related cochlear input impedance (ZC) with “push-pull” active cochlear model involving cochlear cytoarchitecture. Presented three-dimensional cochlear hydro-dynamic model is developed by implementing an active “push-pull” cochlear amplifier mechanism based on Y-shaped organ of Corti cytoarchitecture and using the time-averaged Lagrangian method. For the gerbil PST magnitude, the model results shows (i) the nonlinearity with 10 dB gain, (ii) the 2/3 octave shift in the active case, and (iii) the presence of peaks and valleys which are observed in gerbil in vivo measurement. Additionally, simulation results of chinchilla and cat cochlear |ZC| reflect overall trend of animal measurements, while the gerbil and human cochlear |ZC| are 10 dB lower (> 2 kHz) and 7 dB lower (< 2 kHz) than the measurements respectively.

참고문헌 (Reference)

1 Songer, J. E., "Transmission matrix analysis of the chinchilla middle ear" 122 (122): 932-942, 2007

2 Khanna, S. M., "The Vibratory Pattern of the Round Window in Cats" 50 (50): 1475-1483, 1971

3 조원학, "The Relationship Between Pure-tone Noise and Human Bio-signal Response" 한국정밀공학회 12 (12): 727-731, 2011

4 Heidari, A., "Simulation Based Design of Disk Resonator Based Biosensors under Fabrication Uncertainty" 134 (134): 2012

5 Decraemer, W. F., "Scala vestibuli pressure and three-dimensional stapes velocity measured in direct succession in gerbil" 121 (121): 2774-2791, 2007

6 Olson, E. S., "Observing middle and inner ear mechanics with novel intracochlear pressure sensors" 103 (103): 3445-3463, 1998

7 Edge, R. M., "Morphology of the unfixed cochlea" 124 (124): 1-16, 1998

8 Ruggero, M. A., "Middle-ear response in the chinchilla and its relationship tomechanics at the base of the cochlea" 87 (87): 1612-1629, 1990

9 Onchi, Y., "Mechanism of middle ear" 33 (33): 794-805, 1961

10 Karavitaki, K. D., "Measurements and models of electricallyevoked motion in the gerbil organ of Corti" MIT 2002

11 Dannhof, B. J., "Length of hair cells as a measure of frequency representation in the mammalian inner ear?" 78 (78): 570-573, 1991

12 Olson, E. S., "Intracochlear pressure measurements related to cochlear tuning" 110 (110): 349-367, 2001

13 Yoon, Y. -J., "Intracochlear pressure and derived quantities from a three-dimensional model" 122 (122): 952-966, 2007

14 Yoon, Y. -J., "Intracochlear Pressure and Organ of Corti Impedance from a Linear Active Three- Dimensional Model" 68 (68): 365-372, 2006

15 Lynch, T. J., "Input impedance of the cochlea in cat" 72 (72): 108-130, 1982

16 Tonndorf, J., "Input impedance of inner ear in cats" 75 (75): 752-763, 1966

17 Sokolich, W. G., "Inferred response polarities of cochlear hair cells" 59 (59): 963-974, 1976

18 Aibara, R., "Human middle-ear sound transfer function and cochlear input impedance" 152 (152): 100-109, 2001

19 Heidari, A., "High sensitive dielectric filled Lame mode mass sensor" ELSEVIER SCIENCE SA 188 Special (188 Special): 82-88, 2012

20 Yoon, Y. -J., "Frequency and spatial response of basilar membrane vibration in a three-dimensional gerbil cochlear model" 2 (2): 1449-1458, 2007

21 윤용진, "Feed-Forward and Feed-Backward Amplification Model from Cochlear Cytoarchitecture: An Interspecies Comparison" CELL PRESS 100 (100): 1-10, 201101

22 Brownell, W. E., "Evoked mechanical responses of isolated cochlear outer hair cells" 227 (227): 194-196, 1985

23 Baek, J. D., "Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium" ELSEVIER SCI LTD 45 (45): 1823-1827, 2012

24 Steele, C. R., "Electromechanical models of the outer hair cell, In Mechanics of Hearing" World Scientific 207-215, 1993

25 Steele, C. R., "Comparison of WKB calculations and experimental results for three-dimensional cochlear models" 65 (65): 1007-1018, 1979

26 윤용진, "Analysis and design of a high performance and low cost bio-mass sensor based on the radial contour mode disk resonator" ELSEVIER SCIENCE BV 88 (88): 1730-1732, 201108

27 Lim, K.-M., "A three-dimensional nonlinear active cochlear model analyzed by the WKB-numeric method" 170 (170): 190-205, 2002

28 Shera, C. A., "A symmetry suppresses the cochlear catastrophe" 89 (89): 1276-1289, 1991

29 Puria, S., "A parametric study of cochlear input impedance" 89 (89): 287-309, 1991

30 Bo, W., "A linear cochlear model with active bi-directional coupling" 2013-2016, 2003

31 Peterson, L. C., "A dynamical theory of the cochlea" 22 (22): 369-381, 1950

32 Yoon, Y. -J., "A cochlear model using the time-averaged Lagrangian and the push-pull mechanism in the organ of Corti" 4 (4): 977-986, 2009

33 Geisler, C. D., "A cochlear model using feedforward outer-hair-cell forces" 86 (86): 132-146, 1995

34 Greenwood, D. D., "A cochlear frequency-position function for several species-29 years later" 87 (87): 2592-2605, 1990