Sarcoma - 180 Cell로 유발한 Mouse 복수암에 대한 Astaxanthin 함유 난황의 효과

국문 초록 (Abstract)

몸무게당 25㎍ AEY를 처리한 mouse는 24.8일의 수명을 보여 대조구에 비하여 약 38%의 수명이 연장되었으며, 10㎍ AEY를 처리한 mouse는 19.4일, 50㎍ AEY를 처리한 mouse는 21.9일간 생존하여 각각 8%, 22%의 수명 연장효과를 볼 수 있었으나, CEY 50㎍을 처리한 mouse는 4%의 수명이 연장되었다. 따라서 AEY의 복수암에 대한 수명연장효과는 25㎍ AEY의 처리농도에서 가장 큰 효과를 볼 수 있었다.

다국어 초록 (Multilingual Abstract)

Anticarcinogenic activity of astaxanthin-containing egg yolk(designate AEY) was investigated for mouse ascites carcinogenesis induced by mouse Sarcoma-180(S-180) cells. Female ICR mice(8 mice/treatment, 7~8 weeks of age, 25±1g) were injected, i.p. with S-180 cells(1×10^7cell/ml PBS). Two days later, each mouse was given 0.1ml PBS containing AEY(10, 25 or 50㎍/g body weight) or control egg yolk(CEY ; 50㎍/g body weight) every other day for 7 times. Control mice were only given 0.1ml S-180 cells and 0.1ml PBS. Mice treated with 25㎍/g body weight of AEY showed 24.8 days of life, which was equivalent to 138% of control mice's life(18.0 days). Based on dose-dependant experiment of AEY, mice treated with 10㎍/g body weight showed slightly longer life(19.4 days) relative to mice treated with control mice, and mice treated with 50㎍/g body weight exhibited 21.9 days of life. Mice treated with any dose of AEY exhibited longer life than mice with CEY 50㎍/g body weight. Body weight of mice treated with AEY was reduced relative to that of control mice or CEY-treated mice. These results suggest that AEY inhibits the carcinogenesis of mouse ascites induced by S-180 cells.

목차 (Table of Contents)

• Abstract
  
• 서론
  
• 재료 및 방법
  
• 결과 및 고찰
  
• 요약
  
• 감사의 글
  
• 문헌