Effect of Porosity in Alginate Hydrogels on the Drug Release Behavior

다국어 초록 (Multilingual Abstract)

In this study, two kinds of alginate-based hydrogel were prepared: alginate-furfuryl amine (Alg-F) crosslinked by disulfide-maleimide (S-Ma) and alginate-norbornene (Alg-Nb) crosslinked by disulfide-tetrazine (S-Tz). The “click” chemistry between Alg-Nb and S-Tz during gelation was producing N2 gas and led to the formation of hydrogels with porous structure, in which the porosity could be tuned by adjusting the proportion of crosslinker. As for the crosslinking reaction between Alg-F and S-Ma was performed by DA reaction, which did not produce any by-product and led to the formation of non-porous hydrogel. The drug release study revealed that hydrogel porosity affected drug loading capacity and played a significant role in the kinetics of drug release. days in a sustained manner.