RISS 검색 - 국내학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

Objective: The aim of the current study was to examine the prevalence and time interval of metabolic syndrome development among women with hypertensive disorders of pregnancy compared to those of women with a normal delivery using big data analysis of a customized database using a National Health Insurance System data registry and to compare the prevalence of MS components between the HDP group and the normal delivery group.
Methods: Data from 2002 to 2012 from the National Health Insurance Research Database in Korea was used to compare women diagnosed with HDP with those with a normal singleton pregnancy. The women who had medical checkups between 2009 and 2016 were assessed for MS. Using the customized DB, we conducted a trajectory analysis of MS development in our cohort.
Results: Between 2002 and 2012, there were a total of 4723541 deliveries. Among the women who were analyzed, a total of 305919 underwent a medical examination from 2009 to 2016. MS was diagnosed in 47459 cases (22%). MS was found in 20.3% of the women in the normal group and 37.1% of the women in the HDP group. The time to MS development in women who had experienced pregnancy complicated by HDP was significantly shorter than that of women who did not experience HDP (6.6 ± 3.4 years vs 8.2 ± 3.4 years, p<0.0001). Women with a history of HDP had significantly increased odds of developing MS (OR 1.23; 95% CI, 1.12-1.35) and elevated systolic blood pressure strongly contributed the increased odds of developing MS in the HDP group (OR 1.644; 95% CI, 1.610-1.678).
Conclusion: Our findings suggest that HDP increases the risk of MS development in later life and that MS develops in a shorter period of time in women with HDP than in those with a normal delivery. Women with HDP should be intensively checked for the components of MS.