전북지역 내 급성 A형 간염 환자들 중 심각한 합병증을 갖는 환자들의 임상적 특징과 위험인자

다국어 초록 (Multilingual Abstract)

Background/Aims: Symptomatic acute hepatitis A virus (HAV) infection in adulthood is increasing in Korea. This study analyzes the clinical severity of patients with acute HAV infection and investigates risk factors associated with three severe complications such as prolonged cholestasis, acute kidney injury, and acute liver failure.
Methods: We performed a retrospective analysis of 726 patients diagnosed with acute HAV infection from January 2006 to December 2010 at three tertiary hospitals in Jeonbuk Province, Republic of Korea.
Results: Of 726 patients, the mean age was 30.3 years, 426 (58.6%) were male, and HBsAg was positive in 34 (4.7%). Severe complications of acute HAV infection occurred as follows: prolonged cholestasis in 33 (4.6%), acute kidney injury in 17 (2.3%), and acute liver failure in 16 (2.2%). In the multivariate analysis, age (≥40 years) (Odds ratio 2.63, p=0.024) and peak PT (INR) ≥1.5 (Odds ratio 5.81, p=0.035) were significant risk factors for prolonged cholestasis. Age (≥40 years) (Odds ratio 5.24, p=0.002) and female (Odds ratio 3.11, p=0.036) were significant risk factors for acute kidney injury. Age (≥40 years) (Odds ratio 6.91, p=0.002), HBsAg positivity (Odds ratio 5.02, p=0.049), and peak total bilirubin (Odds ratio 1.11, p=0.001) were significant risk factors for acute liver failure.
Conclusions: Age (≥40 years), female, HBsAg positivity, peak PT (INR) ≥1.5, and peak total bilirubin were significant risk factors for severe complications in acute HAV infection.

목차 (Table of Contents)

• 목 차
• 1. 목 차 ................................................................... I
• 2. 영문초록 ............................................................. II
• 3. Introduction ....................................................... 1
• 4. Materials and Methods ............................... 2
• 5. Results ............................................................... 4
• 6. Discussion ......................................................... 7
• 7. 참고문헌 및 자료 .............................................. 13
• 8. 국문초록 ............................................................... 20