Multifunctional nanoparticles (NPs) can offer great potentials for medical and physiological research. Numerous studies have been reported on multimodal imaging, simultaneous diagnosis, therapy, and cell separation. Herein, we developed core-shell typ...
Multifunctional nanoparticles (NPs) can offer great potentials for medical and physiological research. Numerous studies have been reported on multimodal imaging, simultaneous diagnosis, therapy, and cell separation. Herein, we developed core-shell type quantum dot-embedded silica NPs (SiO<sub>2</sub>@QDs@SiO<sub>2</sub> NPs) as a multifunctional nanomaterial platform. Various functionalities can be easily introduced to the silica core or the shell layer of this nanostructure. We prepared and analyzed a series of SiO<sub>2</sub>@QDs@SiO<sub>2</sub> derived multifunctional NPs. First, using silica coated iron oxide NPs, we built magnetic core-inserted NPs (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@QDs@SiO<sub>2</sub> NPs) for cell separation. Second, through surface polymerization with diacetylene moiety, we synthesized surface-polymerized NPs (SiO<sub>2</sub>@QDs@SiO<sub>2</sub>@ PDA NPs) for dual fluorescence encoding.