Successful pregnancy following transmyometrial embryo transfer after robot-assisted radical trachelectomy

다국어 초록 (Multilingual Abstract)

Radical trachelectomy is a fertility-preserving alternative to radical hysterectomy in carefully selected young women with early-stage cervical cancer. However, in cases with subsequent severe cervical stenosis, assisted reproductive techniques can be difficult. This is a case report of a 34-year-old patient who underwent robot-assisted radical trachelectomy and cerclage for early-stage (IB2) adenosquamous carcinoma. Three months after surgery, the patient underwent ovarian stimulation using a gonadotropin-releasing hormone antagonist protocol. As it was impossible to perform transcervical embryo transfer due to the almost complete absence of the cervical opening, transmyometrial embryo transfer under ultrasound guidance was performed. This resulted in a successful singleton pregnancy. This is the first case of successful pregnancy conceived by in vitro fertilization with transmyometrial embryo transfer in a patient who had previously undergone robot-assisted radical trachele

다국어 초록 (Multilingual Abstract)

Radical trachelectomy is a fertility-preserving alternative to radical hysterectomy in carefully selected young women with early-stage cervical cancer. However, in cases with subsequent severe cervical stenosis, assisted reproductive techniques can be difficult. This is a case report of a 34-year-old patient who underwent robot-assisted radical trachelectomy and cerclage for early-stage (IB2) adenosquamous carcinoma. Three months after surgery, the patient underwent ovarian stimulation using a gonadotropin-releasing hormone antagonist protocol. As it was impossible to perform transcervical embryo transfer due to the almost complete absence of the cervical opening, transmyometrial embryo transfer under ultrasound guidance was performed. This resulted in a successful singleton pregnancy. This is the first case of successful pregnancy conceived by in vitro fertilization with transmyometrial embryo transfer in a patient who had previously undergone robot-assisted radical trachelectomy.

참고문헌 (Reference)

1 Kava-Braverman A, "What is a difficult transfer? Analysis of 7, 714 embryo transfers : the impact of maneuvers during embryo transfers on pregnancy rate and a proposal of objective assessment" 107 : 657-663, 2017

2 Kato O, "Transvaginal-transmyometrial embryo transfer : the Towako method; experiences of 104 cases" 59 : 51-53, 1993

3 Khairy M, "Transmyometrial versus very difficult transcervical embryo transfer : efficacy and safety" 32 : 513-517, 2016

4 Ferreri J, "Transmyometrial embryo transfer as a useful method to overcome difficult embryo transfers : a single-center retrospective study" 22 : 134-138, 2018

5 Jamal W, "Successful pregnancy following novel IVF protocol and transmyometrial embryo transfer after radical vaginal trachelectomy" 18 : 700-703, 2009

6 Sullivan-Pyke CS, "Successful pregnancy following assisted reproduction and transmyometrial embryo transfer in a patient with anatomical distortion of the cervical canal" 60 : 234-238, 2014

7 Willows K, "Fertility-sparing management in cervical cancer : balancing oncologic outcomes with reproductive success" 3 : 9-, 2016

8 Bentivegna E, "Fertility results and pregnancy outcomes after conservative treatment of cervical cancer : a systematic review of the literature" 106 : 1195-1211, 2016

9 Koh WJ, "Cervical cancer, version 3.2019, NCCN Clinical Practice Guidelines in Oncology" 17 : 64-84, 2019