1 PupMed, "pcaA: cyclopropane mycolic acid synthase (Mycobacterium tuberculosis H37Rv)"
2 Hutter B, "Up-regulation of narX, encoding a putative ‘fused nitrate reductase’ in anaerobic dormant Mycobacterium bovis BCG" 178 : 63-69, 1999
3 Berney M, "Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia" 5 : e8614-, 2010
4 Marszalek M, "Two-component systems of Mycobacterium tuberculosis as potential targets for drug development" 71 : 172-178, 2014
5 Heermann R, "Two-component systems in bacteria" Caister Academic Press 181-199, 2012
6 Agarwal R, "Treatment of latent tuberculous infection in India: is it worth the salt?" 22 : 105-106, 2005
7 Beste DJ, "Transcriptomic analysis identifies growth rate modulation as a component of the adaptation of mycobacteria to survival inside the macrophage" 189 : 3969-3976, 2007
8 Caner S, "The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode" 23 : 1075-1083, 2013
9 Grosset J, "The sterilizing value of rifampicin and pyrazinamide in experimental short-course chemotherapy" 53 : 5-12, 1978
10 Sachdeva P, "The sigma factors of Mycobacterium tuberculosis : regulation of the regulators" 277 : 605-626, 2010
11 Rodrigue S, "The sigma factors of Mycobacterium tuberculosis" 30 : 926-941, 2006
12 Lonetto M, "The sigma 70 family : sequence conservation and evolutionary relationships" 174 : 3843-3849, 1992
13 Huaman MA, "The relationship between latent tuberculosis infection and acute myocardial infarction" 66 : 886-892, 2018
14 Daniel TM, "The history of tuberculosis" 100 : 1862-1870, 2006
15 Houben RM, "The global burden of latent tuberculosis infection : a re-estimation using mathematical modelling" 13 : e1002152-, 2016
16 Kendall SL, "The Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses" 84 : 247-255, 2004
17 Thanna S, "Targeting the trehalose utilization pathways of Mycobacterium tuberculosis" 7 : 69-85, 2016
18 Banerjee SK, "Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection" 6 : 25851-, 2016
19 Welin A, "Survival strategies of Mycobacterium tuberculosis inside the human macrophage" Linköping University 2011
20 Lancaster CR, "Succinate : quinone oxidoreductases : new insights from X-ray crystal structures" 1459 : 422-431, 2000
21 Fang C, "Structures and mechanism of transcription initiation by bacterial ECF factors" 47 : 7094-7104, 2019
22 Li L, "Structural basis for transcription initiation by bacterial ECF sigma factors" 10 : 1153-, 2019
23 Tyagi JS, "Signal transduction systems of mycobacteria with special reference to M. tuberculosis" 86 : 93-102, 2004
24 Park HD, "Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis" 48 : 833-843, 2003
25 Agrawal R, "Rv1027c-Rv1028c encode functional KdpDE two-component system in Mycobacterium tuberculosis" 446 : 1172-1178, 2014
26 Jeong EH, "RshA mimetic peptides inhibiting the transcription driven by a Mycobacterium tuberculosis sigma factor SigH" 339 : 392-398, 2006
27 Sohaskey CD, "Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis" 185 : 7247-7256, 2003
28 Zondervan NA, "Regulation of three virulence strategies of Mycobacterium tuberculosis : a success story" 19 : 347-, 2018
29 Sherman DR, "Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin" 98 : 7534-7539, 2001
30 Sohaskey CD, "Regulation of nitrate reductase activity in Mycobacterium tuberculosis by oxygen and nitric oxide" 151 : 3803-3810, 2005
31 Banaiee N, "Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages" 74 : 6449-6457, 2006
32 Kaushal D, "Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH" 99 : 8330-8335, 2002
33 Umesiri FE, "Recent advances toward the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis" 30 : 290-326, 2010
34 Nishimoto T, "Purification and properties of a novel enzyme, trehalose synthase, from Pimelobacter sp. R48" 60 : 640-644, 1996
35 Kelkar DS, "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry" 10 : 2011
36 Hibah NA, "Prevalence of latent tuberculosis infection among multinational healthcare workers in Muhayil Saudi Arabia" 9 : 183-187, 2015
37 Velayati AA, "Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization" 5 : 66-73, 2016
38 Corrales RM, "Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation : consequences for intracellular survival and for phagosome maturation block" 287 : 26187-26199, 2012
39 Gonzalo-Asensio J, "PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence" 3 : e3496-, 2008
40 Kwon KW, "Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K" 7 : 44151-, 2017
41 Beaucher J, "Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms" 45 : 1527-1540, 2002
42 Wayne LG, "Nonreplicating persistence of mycobacterium tuberculosis" 55 : 139-163, 2001
43 Wayne LG, "Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis" 79 : 127-132, 1998
44 Sohaskey CD, "Nitrate enhances the survival of Mycobacterium tuberculosis during inhibition of respiration" 190 : 2981-2986, 2008
45 Zhou P, "Mycobacterium tuberculosis two-component systems and implications in novel vaccines and drugs" 22 : 37-52, 2012
46 Zahrt TC, "Mycobacterium tuberculosis signal transduction system required for persistent infections" 98 : 12706-12711, 2001
47 Huang HL, "Mycobacterium tuberculosis malate synthase structures with fragments reveal a portal for substrate/product exchange" 291 : 27421-27432, 2016
48 Kumar R, "Mycobacterium tuberculosis isocitrate lyase(MtbIcl) : role of divalent cations in modulation of functional and structural properties" 72 : 892-900, 2008
49 Voskuil MI, "Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy" 84 : 218-227, 2004
50 Rao V, "Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule" 201 : 535-543, 2005
51 Singh A, "Mycobacterium tuberculosis WhiB3maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response" 5 : e1000545-, 2009
52 Sharma S, "Mycobacterium tuberculosis DevR/DosR dormancy regulator activation mechanism : dispensability of phosphorylation, cooperativity and essentiality of alpha10 helix" 11 : e0160723-, 2016
53 Gengenbacher M, "Mycobacterium tuberculosis : success through dormancy" 36 : 514-532, 2012
54 Honaker RW, "Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy" 76 : 2587-2593, 2008
55 Giffin MM, "Mutational analysis of the respiratory nitrate transporter NarK2of Mycobacterium tuberculosis" 7 : e45459-, 2012
56 Gruber TM, "Multiple sigma subunits and the partitioning of bacterial transcription space" 57 : 441-466, 2003
57 Pang X, "MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response" 195 : 66-75, 2013
58 He H, "MprAB is a stressresponsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis" 188 : 2134-2143, 2006
59 Bretl DJ, "MprA and DosR coregulate a Mycobacterium tuberculosis virulence operon encoding Rv1813c and Rv1812c" 80 : 3018-3033, 2012
60 Parrish NM, "Mechanisms of latency in Mycobacterium tuberculosis" 6 : 107-112, 1998
61 Pham TV, "Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis" 114 : 7617-7622, 2017
62 Magombedze G, "Latent tuberculosis:models, computational efforts and the pathogen’s regulatory mechanisms during dormancy" 1 : 4-, 2013
63 Velayati AA, "Latent tuberculosis(TB)bacilli : yes or no to preventive chemotherapy" 1 : 1-2, 2012
64 World Health Organization, "Latent TB infection : updated and consolidated guidelines for programmatic management" World Health Organization 2018
65 Bhattacharya M, "Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis" 92 : 263-272, 2010
66 Hutter B, "Increased alanine dehydrogenase activity during dormancy in Mycobacterium smegmatis" 167 : 7-11, 1998
67 McDermott W, "Inapparent infection : relation of latent and dormant infections to microbial persistence" 74 : 485-499, 1959
68 Haydel SE, "In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins" 26 : 195-206, 1999
69 Fenhalls G, "In situ detection of Mycobacterium tuberculosis transcripts in human lung granulomas reveals differential gene expression in necrotic lesions" 70 : 6330-6338, 2002
70 Black GF, "Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa" 16 : 1203-1212, 2009
71 Hernandez Pando R, "Immunogenicity and protection induced by a Mycobacterium tuberculosis sigE mutant in a BALB/c mouse model of progressive pulmonary tuberculosis" 78 : 3168-3176, 2010
72 Graham JE, "Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences(SCOTS)" 96 : 11554-11559, 1999
73 Kalscheuer R, "Handbook of hydrocarbon and lipid microbiology" Springer 527-535, 2010
74 Haydel SE, "Global expression analysis of two-component system regulator genes during Mycobacterium tuberculosis growth in human macrophages" 236 : 341-347, 2004
75 Curcic R, "Gene expression in mycobacteria : transcriptional fusions based on xylE and analysis of the promoter region of the response regulator mtrA from Mycobacterium tuberculosis" 13 : 1057-1064, 1994
76 Haydel SE, "Expression, autoregulation, and DNA binding properties of the Mycobacterium tuberculosis TrcR response regulator" 184 : 2192-2203, 2002
77 Neidhardt FC, "Escherichia coli and Salmonella:cellular and molecular biology" ASM Press 1227-1231, 1996
78 Wayne LG, "Dormancy of Mycobacterium tuberculosis and latency of disease" 13 : 908-914, 1994
79 O’Neill MB, "Diversity of Mycobacterium tuberculosis across Evolutionary Scales" 11 : e1005257-, 2015
80 Ishikawa E, "Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle" 206 : 2879-2888, 2009
81 Sohaskey CD, "Differences in nitrate reduction between Mycobacterium tuberculosis and Mycobacterium bovis are due to differential expression of both narGHJI and narK2" 290 : 129-134, 2009
82 Adeiza MA, "Diagnosis of latent tuberculosis infection : the tuberculin skin test and interferon gamma release assays" 5 : 35-37, 2011
83 Saini DK, "DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR" 150 : 865-875, 2004
84 Parish T, "Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis" 71 : 1134-1140, 2003
85 Cole ST, "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence" 393 : 537-544, 1998
86 Wisedchaisri G, "Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation" 378 : 227-242, 2008
87 Huang CC, "Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis" 277 : 11559-11569, 2002
88 Balkhy HH, "Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia : a population-based study" 11 : 197-201, 2016
89 Kana BD, "Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis" 183 : 7076-7086, 2001
90 Dasgupta N, "Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis" 80 : 141-159, 2000
91 Jordan S, "Cell envelope stress response in Gram-positive bacteria" 32 : 107-146, 2008
92 Smith CV, "Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis" 278 : 1735-1743, 2003
93 Feklistov A, "Bacterial sigma factors: a historical, structural, and genomic perspective" 68 : 357-376, 2014
94 Queiroz A, "Bacterial immunostat : Mycobacterium tuberculosis lipids and their role in the host immune response" 50 : 9-18, 2017
95 Geiman DE, "Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigFdependent genes by microarray analysis" 72 : 1733-1745, 2004
96 Ellenbarger JF, "Anion-pi interactions in computer-aided drug design : modeling the inhibition of malate synthase by phenyl-diketo acids" 58 : 2085-2091, 2018
97 Hutter B, "Analysis of the dormancy-inducible narK2promoter in Mycobacterium bovis BCG" 188 : 141-146, 2000
98 Perez E, "An essential role for phoP in Mycobacterium tuberculosis virulence" 41 : 179-187, 2001
99 Bekierkunst A, "Acute granulomatous response produced in mice by trehalose-6,6-dimycolate" 96 : 958-961, 1968
100 Folkvardsen DB, "A major Mycobacterium tuberculosis outbreak caused by one specific genotype in a low-incidence country : exploring gene profile virulence explanations" 8 : 11869-, 2018