개 이자의 Somatostatin 양성세포의 발달에 관한 면역조직화학적 연구 = Immunohistochemical Study on Somatostatin- and Glucagon- immunoreactive cells in the Developing Canine Pancreas

다국어 초록 (Multilingual Abstract)

Cells immnunoreactive for somatostatin(SOM) and glucagon(GLU) were investigated in postnatal day 0, 7, 14, 28, 90, 180 and adult canine pancreas using light microscopic immunohistochemistry. Pancreatic SOM-immunoreactive cells were found in pancreatic acini, pancreatic duct, and pancreatic islet gradually. Pancreatic SOM-immunoreactive cells were more located in pancreatic parenchyme than pancreatic islet throughout pancreas by postnatal day 28. But there was change by the postnatal 3 months : pancreatic SOM-immunoreactive cells were more located in pancreatic islet than acini and duct. It is suggested that the number of the SOM-immunoreactive cells may not increase with age apparently. A small number of SOM-immunoreactive cells that showed GLU-immunoreactivity were also observed in canine pancreatic islet. The physiologic consequences of these changes remain to be determined.
These results sugegest that SOM in the developing pancreas may relate to the secretion of pancreatic hormones.

목차 (Table of Contents)

• 서 론
• 실험방법
• 1. 실험동물
• 2. 조직처리
• 3. 면역조직화학염색
• 4. 조직의 검경
• 결 과
• 1. 출생후 발달에 따른 개 이자에서 SOM의 변화
• 2. 개 이자에서의 SOM 면역양성반응세포와 GLU 면역양성반응세포의 한 세포내의 공존
• 고 찰
• 결 론
• 1. 출생후 발달에 따른 개 이자에서 SOM의 변화
• 2. 개 이자에서의 SOM 면역양성반응세포와 GLU면역양성반응세포의 비