The association between preeclampsia and autism spectrum disorders among children: a meta-analysis

다국어 초록 (Multilingual Abstract)

Purpose: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
Methods: A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among studies.
Results: The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD [(OR, 1.36; 95% CI, 1.12–1.60) and (RR, 1.30; 95% CI, 1.20–1.41)].
Conclusions: Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.

참고문헌 (Reference)

1 Dodds L, "The role of prenatal, obstetric and neonatal factors in the development of autism" 41 : 891-902, 2011

2 Poorolajal J, "The association between body mass index and preeclampsia : a meta-analysis" 29 : 3670-3676, 2016

3 Wells GA, "The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses" Ottawa Hospital Research Institute

4 Larsson HJ, "Risk factors for autism : perinatal factors, parental psychiatric history, and socioeconomic status" 161 : 916-925, 2005

5 Peters JP, "Reporting quality of systematic reviews and meta-analyses of otorhinolaryngologic articles based on the PRISMA Statement" 10 : e0136540-, 2015

6 Wang C, "Prenatal, perinatal, and postnatal factors associated with autism: a meta-analysis" 96 : e6696-, 2017

7 Kolevzon A, "Prenatal and perinatal risk factors for autism : a review and integration of findings" 161 : 326-333, 2007

8 Walker CK, "Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay" 169 : 154-162, 2015

9 Mann JR, "Pre-eclampsia, birth weight, and autism spectrum disorders" 40 : 548-554, 2010

10 Dachew BA, "Pre-eclampsia and the risk of autism-spectrum disorder in offspring : meta-analysis" 212 : 142-147, 2018

11 Adam I, "Placenta previa and pre-eclampsia : analyses of 1645 cases at medani maternity hospital, Sudan" 4 : 32-, 2013

12 Glasson EJ, "Perinatal factors and the development of autism : a population study" 61 : 618-627, 2004

13 Polo-Kantola P, "Obstetric risk factors and autism spectrum disorders in Finland" 164 : 358-365, 2014

14 Woodham PC, "Midgestation maternal serum 25-hydroxyvitamin D level and soluble fms-like tyrosine kinase 1/placental growth factor ratio as predictors of severe preeclampsia" 58 : 1120-1125, 2011

15 Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration(BMI Mediated Effects), "Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke : a pooled analysis of 97 prospective cohorts with 1∙8million participants" 383 : 970-983, 2014

16 Langridge AT, "Maternal conditions and perinatal characteristics associated with autism spectrum disorder and intellectual disability" 8 : e50963-, 2013

17 Kramer MS, "Incidence, risk factors, and temporal trends in severe postpartum hemorrhage" 209 : 449.e1-7-, 2013

18 Buchmayer S, "Can association between preterm birth and autism be explained by maternal or neonatal morbidity?" 124 : e817-25, 2009

19 Egger M, "Bias in meta-analysis detected by a simple, graphical test" 315 : 629-634, 1997

20 Burstyn I, "Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada" 30 : 125-134, 2010

21 Raz R, "Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy : a nested case-control analysis within the Nurses'Health Study II Cohort" 123 : 264-270, 2015

22 Moore GS, "Autism risk in small- and large-for-gestational-age infants" 206 : 314.e1-319.e1, 2012

23 Bailey A, "Autism : towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives" 37 : 89-126, 1996

24 Getahun D, "Association of perinatal risk factors with autism spectrum disorder" 34 : 295-304, 2017

25 Xiang AH, "Association of maternal diabetes with autism in offspring" 313 : 1425-1434, 2015

26 Li YM, "Association between maternal obesity and autism spectrum disorder in offspring : a metaanalysis" 46 : 95-102, 2016