성인 아토피피부염 환자에서 히스타민 제한식이의 효과 = Effect of a Histamine-free Diet in Adult Patients with Atopic Dermatitis성인 아토피피부염 환자에서 히스타민 제한식이의 효과

다국어 초록 (Multilingual Abstract)

Background: For atopic dermatitis (AD), the causal relationship between food and exacerbation is relatively weak in adults compared to children. However, many adult patients report food-related aggravation of AD, and some may have histamine intolerance. Objective: The aim of this study was to evaluate the role of ingested histamine and investigate the effect of a histamine-free diet in adult patients with AD. Methods: Adult patients with AD and healthy controls were enrolled. Patients were prohibited from eating foods with high amounts of histamine for 4 weeks. There were no diet restrictions for the controls. The eczema area and severity index (EASI) and degree of pruritus using the visual analogue scale (VAS) were evaluated. Plasma histamine levels and diamine oxidase (DAO) activity were determined, and compared with those of the control group. Results: Seventeen adult patients were recruited and of these, 12 completed the 4-week histamine-free diet. There was no significant difference in the basal plasma histamine levels between the patients and controls. Basal DAO activity was significantly higher in patients compared to the controls. There was no significant difference in plasma histamine levels after the histamine free-diet and DAO activity was not altered. Moreover, EASI and VAS were similar before and after the histamine-free diet. Conclusion: Ingested histamine might be unrelated with AD severity and a histamine-free diet is unhelpful for adult patients with AD. (Korean J Dermatol 2015;53(3):196∼201)